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- W4324330131 abstract "Abstract Slow waves of neuronal activity are a fundamental component of sleep that are proposed to have homeostatic and restorative functions. Despite this, their interaction with pathology is unclear and there is only indirect evidence of their presence during wakefulness. Using intracortical recordings from the temporal lobe of 25 patients with epilepsy, we demonstrate the existence of local wake slow waves (LoWS) with key features of sleep slow waves, including the down-state of neuronal firing. LoWS were distinct from slow waves recorded in people without epilepsy and showed evidence of adaptation during periods of increased normal (cognitive task) and abnormal (interictal epileptiform discharges, IEDs) activity. Importantly, we also provide evidence that LoWS reduce increases in network excitability during IEDs but are associated with poorer memory. We therefore propose an “epilepsy homeostasis hypothesis”: that slow waves are activated in epilepsy to reduce aberrant activity at the price of transient cognitive impairment." @default.
- W4324330131 created "2023-03-16" @default.
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- W4324330131 date "2023-03-15" @default.
- W4324330131 modified "2023-09-27" @default.
- W4324330131 title "Wake slow waves in focal human epilepsy impact network activity and cognition" @default.
- W4324330131 doi "https://doi.org/10.21203/rs.3.rs-2693418/v1" @default.
- W4324330131 hasPublicationYear "2023" @default.
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