Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324331654> ?p ?o ?g. }
- W4324331654 endingPage "112264" @default.
- W4324331654 startingPage "112264" @default.
- W4324331654 abstract "Histone chaperones are an important class of proteins that regulate chromatin accessibility for DNA-templated processes. Spt6 is a conserved histone chaperone and key regulator of transcription and chromatin structure. However, its functions outside of these roles have been little explored. In this work, we demonstrate a requirement for S. cerevisiae Spt6 in DNA replication and, more broadly, as a regulator of genome stability. Depletion or mutation of Spt6 impairs DNA replication in vivo. Additionally, spt6 mutants are sensitive to DNA replication stress-inducing agents. Interestingly, this sensitivity is independent of the association of Spt6 with RNA polymerase II (RNAPII), suggesting that spt6 mutants have a transcription-independent impairment of DNA replication. Specifically, genomic studies reveal that spt6 mutants have decreased loading of the MCM replicative helicase at replication origins, suggesting that Spt6 promotes origin licensing. Our results identify Spt6 as a regulator of genome stability, at least in part through a role in DNA replication." @default.
- W4324331654 created "2023-03-16" @default.
- W4324331654 creator A5025993887 @default.
- W4324331654 creator A5050583092 @default.
- W4324331654 date "2023-03-01" @default.
- W4324331654 modified "2023-10-01" @default.
- W4324331654 title "The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability" @default.
- W4324331654 cites W1547834895 @default.
- W4324331654 cites W1759171139 @default.
- W4324331654 cites W1884404671 @default.
- W4324331654 cites W1965813899 @default.
- W4324331654 cites W1968153105 @default.
- W4324331654 cites W1971491328 @default.
- W4324331654 cites W1975001355 @default.
- W4324331654 cites W1975150670 @default.
- W4324331654 cites W1976561164 @default.
- W4324331654 cites W1979147291 @default.
- W4324331654 cites W1982262507 @default.
- W4324331654 cites W1984085338 @default.
- W4324331654 cites W1986258535 @default.
- W4324331654 cites W2000625991 @default.
- W4324331654 cites W2001198865 @default.
- W4324331654 cites W2003153093 @default.
- W4324331654 cites W2003844796 @default.
- W4324331654 cites W2003968433 @default.
- W4324331654 cites W2007917670 @default.
- W4324331654 cites W2008486131 @default.
- W4324331654 cites W2008809596 @default.
- W4324331654 cites W2012144576 @default.
- W4324331654 cites W2015918838 @default.
- W4324331654 cites W2019607361 @default.
- W4324331654 cites W2019808923 @default.
- W4324331654 cites W2025998934 @default.
- W4324331654 cites W2030910398 @default.
- W4324331654 cites W2040860750 @default.
- W4324331654 cites W2041837518 @default.
- W4324331654 cites W2041859788 @default.
- W4324331654 cites W2046714245 @default.
- W4324331654 cites W2048908822 @default.
- W4324331654 cites W2051553283 @default.
- W4324331654 cites W2056384682 @default.
- W4324331654 cites W2058761693 @default.
- W4324331654 cites W2059504699 @default.
- W4324331654 cites W2062226032 @default.
- W4324331654 cites W2071164795 @default.
- W4324331654 cites W2072067002 @default.
- W4324331654 cites W2077420823 @default.
- W4324331654 cites W2085493431 @default.
- W4324331654 cites W2085759022 @default.
- W4324331654 cites W2095004958 @default.
- W4324331654 cites W2101359917 @default.
- W4324331654 cites W2102678326 @default.
- W4324331654 cites W2104073930 @default.
- W4324331654 cites W2105222529 @default.
- W4324331654 cites W2108234281 @default.
- W4324331654 cites W2110417468 @default.
- W4324331654 cites W2112429774 @default.
- W4324331654 cites W2115998813 @default.
- W4324331654 cites W2116015677 @default.
- W4324331654 cites W2118483110 @default.
- W4324331654 cites W2119112640 @default.
- W4324331654 cites W2125717020 @default.
- W4324331654 cites W2126027054 @default.
- W4324331654 cites W2126093266 @default.
- W4324331654 cites W2132539769 @default.
- W4324331654 cites W2133127556 @default.
- W4324331654 cites W2133435867 @default.
- W4324331654 cites W2134421533 @default.
- W4324331654 cites W2135556978 @default.
- W4324331654 cites W2136779909 @default.
- W4324331654 cites W2140590347 @default.
- W4324331654 cites W2141473257 @default.
- W4324331654 cites W2142125232 @default.
- W4324331654 cites W2142294062 @default.
- W4324331654 cites W2143028761 @default.
- W4324331654 cites W2144273758 @default.
- W4324331654 cites W2147078566 @default.
- W4324331654 cites W2149799561 @default.
- W4324331654 cites W2149993601 @default.
- W4324331654 cites W2150136726 @default.
- W4324331654 cites W2157726708 @default.
- W4324331654 cites W2162778315 @default.
- W4324331654 cites W2166434010 @default.
- W4324331654 cites W2169048194 @default.
- W4324331654 cites W2170551349 @default.
- W4324331654 cites W2171808845 @default.
- W4324331654 cites W2256210076 @default.
- W4324331654 cites W2257945489 @default.
- W4324331654 cites W2265525210 @default.
- W4324331654 cites W2341539131 @default.
- W4324331654 cites W2423627688 @default.
- W4324331654 cites W2463453322 @default.
- W4324331654 cites W2472184758 @default.
- W4324331654 cites W2473838984 @default.
- W4324331654 cites W2558797341 @default.
- W4324331654 cites W2566377538 @default.
- W4324331654 cites W2570296944 @default.
- W4324331654 cites W2598480796 @default.