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• W4324353722 abstract "Abstract Although the introduction of glycerosomes have enriched strategies for efficient transdermal drug delivery, the inclusion of cholesterol as a membrane stabilizer has limited their clinical application. The current study describes the development and optimization of a new type of glycerosome (S-glycerosome) that is formed in glycerol solution with β-sitosterol as the stabilizer. Moreover, the transdermal permeation properties of lappaconitine (LA)-loaded S-glycerosomes and peppermint oil (PO)-mediated S-glycerosomes (PO-S-glycerosomes) are evaluated, and the lipid alterations in the stratum corneum are analyzed via lipidomics. Results show that the LA-loaded S-glycerosomes have a mean size of 145.3 ± 7.81 nm and encapsulation efficiency of 73.14 ± 0.35%. Moreover, the addition of PO positively impacts transdermal flux, peaking at 0.4% (w/v) PO. Tracing of the fluorescent probe P4 further revealed that PO-S-glycerosomes penetrate deeper into the skin than S-glycerosomes and conventional liposomes. Additionally, treatment with PO-S-glycerosomes alters the isoform type, number, and composition of sphingolipids, glycerophospholipids, glycerolipids, and fatty acids in the stratum corneum, with the most notable effect observed for ceramides, the main component of sphingolipids. Furthermore, the administration of PO-S-glycerosomes improves the treatment efficacy of xylene-induced inflammation in mice. Collectively, these findings demonstrate the feasibility of β-sitosterol as a stabilizer in glycerosomes. Additionally, the inclusion of PO improves the transdermal permeation of S-glycerosomes, potentially by altering the stratum corneum lipids." @default.
• W4324353722 created "2023-03-16" @default.
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• W4324353722 date "2023-03-15" @default.
• W4324353722 modified "2023-10-14" @default.
• W4324353722 title "Stratum corneum lipidomics analysis of the transdermal permeability achieved by phytosterol-mediated glycerosomes combined with peppermint oil" @default.
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• W4324353722 doi "https://doi.org/10.21203/rs.3.rs-2629347/v1" @default.
• W4324353722 hasPublicationYear "2023" @default.
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