Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324356736> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4324356736 abstract "End-stage organ failure is a major global issue, with the liver being the second-highest transplanted organ due to lifestyle choices or other conditions. In the field of biomedical engineering, artificial organ manufacturing has been a possible alternative to organ transplants by aiming to achieve less immune rejection, more efficient production, and higher accessibility. Of the biological manufacturing methods today, two up-and-coming technologies for the liver include 3D bioprinting and decellularized organ regeneration. By analyzing general stages of 3D bioprinting and decellularization for liver development and comparing it to the cellular and genetic stages of hepatic development in the embryo, dilemmas and successes in bioartificial manufacturing can be identified. Overall, neither artificial methodology can replicate the genetic influence or non-liver based influence of hepatogenesis. 3D bioprinting is similar to hepatogenesis in cell development and construction, but contains shortcomings in vascularization, which can be addressed using the vasculogenesis and angiogenesis processes in hepatic development. Decellularization allows for cell differentiation, although it is unable to instill natural cellular distribution and gradual ECM development. This may cause blockages for clinical use in the future. Both methods have potential for bioartificial liver development and clinical application, but 3D bioprinting technology is more aligned with the stages of hepatic development, which has proven to induce fewer errors in the physiological nature of the manufactured liver. In the future, modification and research must be conducted on the specific stages of these methodologies for either to create an operational bioartificial liver for clinical use." @default.
- W4324356736 created "2023-03-16" @default.
- W4324356736 creator A5043655003 @default.
- W4324356736 creator A5061052565 @default.
- W4324356736 date "2022-08-31" @default.
- W4324356736 modified "2023-10-01" @default.
- W4324356736 title "Bioartificial Liver Manufacturing Methodologies in Comparison to Hepatogenesis" @default.
- W4324356736 doi "https://doi.org/10.47611/jsrhs.v11i3.3385" @default.
- W4324356736 hasPublicationYear "2022" @default.
- W4324356736 type Work @default.
- W4324356736 citedByCount "0" @default.
- W4324356736 crossrefType "journal-article" @default.
- W4324356736 hasAuthorship W4324356736A5043655003 @default.
- W4324356736 hasAuthorship W4324356736A5061052565 @default.
- W4324356736 hasBestOaLocation W43243567361 @default.
- W4324356736 hasConcept C10854531 @default.
- W4324356736 hasConcept C136229726 @default.
- W4324356736 hasConcept C141071460 @default.
- W4324356736 hasConcept C190672674 @default.
- W4324356736 hasConcept C202751555 @default.
- W4324356736 hasConcept C2776200302 @default.
- W4324356736 hasConcept C2779718196 @default.
- W4324356736 hasConcept C28328180 @default.
- W4324356736 hasConcept C2993619895 @default.
- W4324356736 hasConcept C2994427840 @default.
- W4324356736 hasConcept C41008148 @default.
- W4324356736 hasConcept C49892992 @default.
- W4324356736 hasConcept C55493867 @default.
- W4324356736 hasConcept C71867830 @default.
- W4324356736 hasConcept C71924100 @default.
- W4324356736 hasConcept C86803240 @default.
- W4324356736 hasConcept C95444343 @default.
- W4324356736 hasConceptScore W4324356736C10854531 @default.
- W4324356736 hasConceptScore W4324356736C136229726 @default.
- W4324356736 hasConceptScore W4324356736C141071460 @default.
- W4324356736 hasConceptScore W4324356736C190672674 @default.
- W4324356736 hasConceptScore W4324356736C202751555 @default.
- W4324356736 hasConceptScore W4324356736C2776200302 @default.
- W4324356736 hasConceptScore W4324356736C2779718196 @default.
- W4324356736 hasConceptScore W4324356736C28328180 @default.
- W4324356736 hasConceptScore W4324356736C2993619895 @default.
- W4324356736 hasConceptScore W4324356736C2994427840 @default.
- W4324356736 hasConceptScore W4324356736C41008148 @default.
- W4324356736 hasConceptScore W4324356736C49892992 @default.
- W4324356736 hasConceptScore W4324356736C55493867 @default.
- W4324356736 hasConceptScore W4324356736C71867830 @default.
- W4324356736 hasConceptScore W4324356736C71924100 @default.
- W4324356736 hasConceptScore W4324356736C86803240 @default.
- W4324356736 hasConceptScore W4324356736C95444343 @default.
- W4324356736 hasIssue "3" @default.
- W4324356736 hasLocation W43243567361 @default.
- W4324356736 hasOpenAccess W4324356736 @default.
- W4324356736 hasPrimaryLocation W43243567361 @default.
- W4324356736 hasRelatedWork W2000268978 @default.
- W4324356736 hasRelatedWork W2314454902 @default.
- W4324356736 hasRelatedWork W2578859604 @default.
- W4324356736 hasRelatedWork W2773047424 @default.
- W4324356736 hasRelatedWork W2969872218 @default.
- W4324356736 hasRelatedWork W2974347642 @default.
- W4324356736 hasRelatedWork W3080143997 @default.
- W4324356736 hasRelatedWork W4213232733 @default.
- W4324356736 hasRelatedWork W4324356736 @default.
- W4324356736 hasRelatedWork W807947237 @default.
- W4324356736 hasVolume "11" @default.
- W4324356736 isParatext "false" @default.
- W4324356736 isRetracted "false" @default.
- W4324356736 workType "article" @default.