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• W4324363992 startingPage "5598" @default.
• W4324363992 abstract "Window of implantation (WOI) genes have been comprehensively identified at the single cell level. DNA methylation changes in cervical secretions are associated with in vitro fertilization embryo transfer (IVF-ET) outcomes. Using a machine learning (ML) approach, we aimed to determine which methylation changes in WOI genes from cervical secretions best predict ongoing pregnancy during embryo transfer. A total of 2708 promoter probes were extracted from mid-secretory phase cervical secretion methylomic profiles for 158 WOI genes, and 152 differentially methylated probes (DMPs) were selected. Fifteen DMPs in 14 genes (BMP2, CTSA, DEFB1, GRN, MTF1, SERPINE1, SERPINE2, SFRP1, STAT3, TAGLN2, TCF4, THBS1, ZBTB20, ZNF292) were identified as the most relevant to ongoing pregnancy status. These 15 DMPs yielded accuracy rates of 83.53%, 85.26%, 85.78%, and 76.44%, and areas under the receiver operating characteristic curves (AUCs) of 0.90, 0.91, 0.89, and 0.86 for prediction by random forest (RF), naïve Bayes (NB), support vector machine (SVM), and k-nearest neighbors (KNN), respectively. SERPINE1, SERPINE2, and TAGLN2 maintained their methylation difference trends in an independent set of cervical secretion samples, resulting in accuracy rates of 71.46%, 80.06%, 80.72%, and 80.68%, and AUCs of 0.79, 0.84, 0.83, and 0.82 for prediction by RF, NB, SVM, and KNN, respectively. Our findings demonstrate that methylation changes in WOI genes detected noninvasively from cervical secretions are potential markers for predicting IVF-ET outcomes. Further studies of cervical secretion of DNA methylation markers may provide a novel approach for precision embryo transfer." @default.
• W4324363992 created "2023-03-16" @default.
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• W4324363992 date "2023-03-15" @default.
• W4324363992 modified "2023-10-08" @default.
• W4324363992 title "DNA Methylation of Window of Implantation Genes in Cervical Secretions Predicts Ongoing Pregnancy in Infertility Treatment" @default.
• W4324363992 cites W1114971376 @default.
• W4324363992 cites W1553210192 @default.
• W4324363992 cites W1964021013 @default.
• W4324363992 cites W1970401017 @default.
• W4324363992 cites W1982242727 @default.
• W4324363992 cites W1982579962 @default.
• W4324363992 cites W1992989458 @default.
• W4324363992 cites W2002750345 @default.
• W4324363992 cites W2004822360 @default.
• W4324363992 cites W2006617902 @default.
• W4324363992 cites W2008025540 @default.
• W4324363992 cites W2017907666 @default.
• W4324363992 cites W2020802351 @default.
• W4324363992 cites W2022783679 @default.
• W4324363992 cites W2033759767 @default.
• W4324363992 cites W2034312561 @default.
• W4324363992 cites W2048984796 @default.
• W4324363992 cites W2052609182 @default.
• W4324363992 cites W2088430547 @default.
• W4324363992 cites W2122796019 @default.
• W4324363992 cites W2136798617 @default.
• W4324363992 cites W2136895197 @default.
• W4324363992 cites W2139187815 @default.
• W4324363992 cites W2156665896 @default.
• W4324363992 cites W2161479512 @default.
• W4324363992 cites W2162731834 @default.
• W4324363992 cites W2167917245 @default.
• W4324363992 cites W2233824638 @default.
• W4324363992 cites W2267486437 @default.
• W4324363992 cites W2283169635 @default.
• W4324363992 cites W2314880008 @default.
• W4324363992 cites W2401206178 @default.
• W4324363992 cites W2510344935 @default.
• W4324363992 cites W2766234621 @default.
• W4324363992 cites W2770288074 @default.
• W4324363992 cites W2778263952 @default.
• W4324363992 cites W2783826990 @default.
• W4324363992 cites W2810656455 @default.
• W4324363992 cites W2894882879 @default.
• W4324363992 cites W2900860676 @default.
• W4324363992 cites W2902437253 @default.
• W4324363992 cites W2918152109 @default.
• W4324363992 cites W2927173694 @default.
• W4324363992 cites W2944746946 @default.
• W4324363992 cites W2965181622 @default.
• W4324363992 cites W2966521813 @default.
• W4324363992 cites W2969323577 @default.
• W4324363992 cites W2973453946 @default.
• W4324363992 cites W2974748598 @default.
• W4324363992 cites W2976814231 @default.
• W4324363992 cites W2980134707 @default.
• W4324363992 cites W2982466528 @default.
• W4324363992 cites W2990458990 @default.
• W4324363992 cites W2991542136 @default.
• W4324363992 cites W2991551182 @default.
• W4324363992 cites W2998842462 @default.
• W4324363992 cites W3005937917 @default.
• W4324363992 cites W3008183745 @default.
• W4324363992 cites W3012096999 @default.
• W4324363992 cites W3013068423 @default.
• W4324363992 cites W3020893169 @default.
• W4324363992 cites W3048444863 @default.
• W4324363992 cites W3084052485 @default.
• W4324363992 cites W3086909323 @default.
• W4324363992 cites W3089320542 @default.
• W4324363992 cites W3092492731 @default.
• W4324363992 cites W3100377772 @default.
• W4324363992 cites W3113933142 @default.
• W4324363992 cites W3127350545 @default.
• W4324363992 cites W3165519339 @default.
• W4324363992 cites W3182171671 @default.
• W4324363992 cites W3183357284 @default.
• W4324363992 cites W3194854179 @default.
• W4324363992 cites W3206680645 @default.
• W4324363992 cites W4200039502 @default.
• W4324363992 cites W4200565001 @default.
• W4324363992 cites W4205452154 @default.
• W4324363992 cites W4206796127 @default.
• W4324363992 cites W4244095134 @default.
• W4324363992 cites W4280571147 @default.
• W4324363992 cites W4285413085 @default.
• W4324363992 doi "https://doi.org/10.3390/ijms24065598" @default.
• W4324363992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36982674" @default.
• W4324363992 hasPublicationYear "2023" @default.

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