Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324365367> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4324365367 endingPage "108503" @default.
- W4324365367 startingPage "108503" @default.
- W4324365367 abstract "Trichinella spiralis is a zoonotic parasite with worldwide distribution that can seriously harm human health and animal husbandry. Ornithine decarboxylase is a component of the acid resistance (AR) system in Escherichia coli. The aim of this study was to investigate the role that T. spiralis ornithine decarboxylase (TsODC) plays in the acid resistance mechanism of T. spiralis. This study involved assessing the transcription and expression of TsODC in worms under acidic conditions. According to mRNA sequences published by NCBI and the results of molecular biology experiments, the complete TsODC sequence was cloned and expressed. rTsODC had good immunogenicity, and immunofluorescence analysis revealed that TsODC was principally localized on the surface tissues of the nematode, especially at the head and tail. qRT‒PCR and Western blotting analysis indicated that the relative expression levels of TsODC mRNA and protein were highest when cultured at pH 2.5 for 2 h. The muscle larvae (ML) of T. spiralis were treated with curcumin and rapamycin, as well as arginine and TsODC polyantisera. The expression levels of TsODC mRNA and protein were significantly increased by arginine and suppressed by curcumin and rapamycin. After reducing the amount of TsODC, the relative expression of TsODC mRNA and the survival rate of T. spiralis ML were both reduced when compared to these values in the phosphate-buffered saline (PBS) group. The results indicated that TsODC is a member of the T. spiralis AR system and different treatments on TsODC have different effects; thus, these treatments might be a new way to prevent T. spiralis infection." @default.
- W4324365367 created "2023-03-16" @default.
- W4324365367 creator A5001089182 @default.
- W4324365367 creator A5004280560 @default.
- W4324365367 creator A5020831277 @default.
- W4324365367 creator A5026448857 @default.
- W4324365367 creator A5031520682 @default.
- W4324365367 creator A5035520440 @default.
- W4324365367 creator A5078428743 @default.
- W4324365367 date "2023-06-01" @default.
- W4324365367 modified "2023-09-27" @default.
- W4324365367 title "The mechanism of acid resistance by ornithine decarboxylase in Trichinella spiralis" @default.
- W4324365367 cites W1969616774 @default.
- W4324365367 cites W2004800814 @default.
- W4324365367 cites W2041852134 @default.
- W4324365367 cites W2105657949 @default.
- W4324365367 cites W2136806453 @default.
- W4324365367 cites W2152434411 @default.
- W4324365367 cites W2463295359 @default.
- W4324365367 cites W2967855330 @default.
- W4324365367 cites W3011666871 @default.
- W4324365367 cites W3044742558 @default.
- W4324365367 cites W3087339259 @default.
- W4324365367 cites W3136743360 @default.
- W4324365367 cites W4283372824 @default.
- W4324365367 doi "https://doi.org/10.1016/j.exppara.2023.108503" @default.
- W4324365367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36925097" @default.
- W4324365367 hasPublicationYear "2023" @default.
- W4324365367 type Work @default.
- W4324365367 citedByCount "0" @default.
- W4324365367 crossrefType "journal-article" @default.
- W4324365367 hasAuthorship W4324365367A5001089182 @default.
- W4324365367 hasAuthorship W4324365367A5004280560 @default.
- W4324365367 hasAuthorship W4324365367A5020831277 @default.
- W4324365367 hasAuthorship W4324365367A5026448857 @default.
- W4324365367 hasAuthorship W4324365367A5031520682 @default.
- W4324365367 hasAuthorship W4324365367A5035520440 @default.
- W4324365367 hasAuthorship W4324365367A5078428743 @default.
- W4324365367 hasConcept C104317684 @default.
- W4324365367 hasConcept C105580179 @default.
- W4324365367 hasConcept C121289238 @default.
- W4324365367 hasConcept C153911025 @default.
- W4324365367 hasConcept C164007495 @default.
- W4324365367 hasConcept C165901193 @default.
- W4324365367 hasConcept C181199279 @default.
- W4324365367 hasConcept C203014093 @default.
- W4324365367 hasConcept C2776928777 @default.
- W4324365367 hasConcept C2777167505 @default.
- W4324365367 hasConcept C2777468819 @default.
- W4324365367 hasConcept C2779703059 @default.
- W4324365367 hasConcept C2781320125 @default.
- W4324365367 hasConcept C515207424 @default.
- W4324365367 hasConcept C55493867 @default.
- W4324365367 hasConcept C86803240 @default.
- W4324365367 hasConcept C89423630 @default.
- W4324365367 hasConceptScore W4324365367C104317684 @default.
- W4324365367 hasConceptScore W4324365367C105580179 @default.
- W4324365367 hasConceptScore W4324365367C121289238 @default.
- W4324365367 hasConceptScore W4324365367C153911025 @default.
- W4324365367 hasConceptScore W4324365367C164007495 @default.
- W4324365367 hasConceptScore W4324365367C165901193 @default.
- W4324365367 hasConceptScore W4324365367C181199279 @default.
- W4324365367 hasConceptScore W4324365367C203014093 @default.
- W4324365367 hasConceptScore W4324365367C2776928777 @default.
- W4324365367 hasConceptScore W4324365367C2777167505 @default.
- W4324365367 hasConceptScore W4324365367C2777468819 @default.
- W4324365367 hasConceptScore W4324365367C2779703059 @default.
- W4324365367 hasConceptScore W4324365367C2781320125 @default.
- W4324365367 hasConceptScore W4324365367C515207424 @default.
- W4324365367 hasConceptScore W4324365367C55493867 @default.
- W4324365367 hasConceptScore W4324365367C86803240 @default.
- W4324365367 hasConceptScore W4324365367C89423630 @default.
- W4324365367 hasLocation W43243653671 @default.
- W4324365367 hasLocation W43243653672 @default.
- W4324365367 hasOpenAccess W4324365367 @default.
- W4324365367 hasPrimaryLocation W43243653671 @default.
- W4324365367 hasRelatedWork W1554810227 @default.
- W4324365367 hasRelatedWork W2084370677 @default.
- W4324365367 hasRelatedWork W2091413967 @default.
- W4324365367 hasRelatedWork W2103702459 @default.
- W4324365367 hasRelatedWork W2167320966 @default.
- W4324365367 hasRelatedWork W2272183236 @default.
- W4324365367 hasRelatedWork W2318921316 @default.
- W4324365367 hasRelatedWork W2408067028 @default.
- W4324365367 hasRelatedWork W2413124027 @default.
- W4324365367 hasRelatedWork W2473840594 @default.
- W4324365367 hasVolume "249" @default.
- W4324365367 isParatext "false" @default.
- W4324365367 isRetracted "false" @default.
- W4324365367 workType "article" @default.