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- W4324368170 endingPage "127363" @default.
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- W4324368170 abstract "Microorganisms produce active surface agents called lipopeptides (LPs) which are amphiphilic in nature. They are cyclic or linear compounds and are predominantly isolated from Bacillus and Pseudomonas species. LPs show antimicrobial activity towards various plant pathogens and act by inhibiting the growth of these organisms. Several mechanisms are exhibited by LPs, such as cell membrane disruption, biofilm production, induced systematic resistance, improving plant growth, inhibition of spores, etc., making them suitable as biocontrol agents and highly advantageous for industrial utilization. The biosynthesis of lipopeptides involves large multimodular enzymes referred to as non-ribosomal peptide synthases. These enzymes unveil a broad range of engineering approaches through which lipopeptides can be overproduced and new LPs can be generated asserting high efficacy. Such approaches involve several synthetic biology systems and metabolic engineering techniques such as promotor engineering, enhanced precursor availability, condensation domain engineering, and adenylation domain engineering. Finally, this review provides an update of the applications of lipopeptides in various fields." @default.
- W4324368170 created "2023-03-16" @default.
- W4324368170 creator A5015295341 @default.
- W4324368170 creator A5037785235 @default.
- W4324368170 creator A5063182958 @default.
- W4324368170 date "2023-06-01" @default.
- W4324368170 modified "2023-09-26" @default.
- W4324368170 title "Microbial lipopeptides: Properties, mechanics and engineering for novel lipopeptides" @default.
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