FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324375261> ?p ?o ?g. }

• W4324375261 abstract "Malignant glioma is the most frequent primary tumor of the central nervous system. PDCL3 is a member of the phosducin-like protein family, and its imbalance has been shown to be associated with several human diseases. However, the underlying role of PDCL3 in human malignant cancers, especially in malignant gliomas, is unclear. In this study, we combined public database analysis and experimental verification to explore the differential expression, prognostic value and potential functions and mechanisms of PDCL3. The results revealed that PDCL3 is upregulated in multiple cancers and acts as a potential prognostic biomarker of glioma. Mechanistically, PDCL3 expression is associated with epigenetic modifications and genetic mutations. PDCL3 may directly interact with the chaperonin-containing TCP1 complex, regulating cell malignancy, cell communication and the extracellular matrix. More importantly, the association of PDCL3 with the infiltration of immune cells, immunomodulatory genes, immune checkpoints, cancer stemness and angiogenesis suggested that PDCL3 may regulate the glioma immune landscape. Furthermore, PDCL3 interference also decreased the proliferation, invasion and migration of glioma cells. In conclusion, PDCL3 is a novel oncogene and can be adopted as a biomarker with value in assisting clinical diagnosis, predicting patient outcomes and assessing the immune landscape of the tumor microenvironment in glioma." @default.
• W4324375261 created "2023-03-16" @default.
• W4324375261 creator A5002450016 @default.
• W4324375261 creator A5012664679 @default.
• W4324375261 creator A5018652999 @default.
• W4324375261 creator A5058723416 @default.
• W4324375261 creator A5083503582 @default.
• W4324375261 creator A5091018084 @default.
• W4324375261 date "2023-03-15" @default.
• W4324375261 modified "2023-09-27" @default.
• W4324375261 title "Phosducin-like 3 is a novel prognostic and onco-immunological biomarker in glioma: A multi-omics analysis with experimental verification" @default.
• W4324375261 cites W1790297113 @default.
• W4324375261 cites W1976366817 @default.
• W4324375261 cites W1981513994 @default.
• W4324375261 cites W1983955583 @default.
• W4324375261 cites W1990824001 @default.
• W4324375261 cites W2011753572 @default.
• W4324375261 cites W2026480865 @default.
• W4324375261 cites W2036355405 @default.
• W4324375261 cites W2048129953 @default.
• W4324375261 cites W2049471507 @default.
• W4324375261 cites W2073586533 @default.
• W4324375261 cites W2078094267 @default.
• W4324375261 cites W2100589429 @default.
• W4324375261 cites W2110864232 @default.
• W4324375261 cites W2114998237 @default.
• W4324375261 cites W2160270021 @default.
• W4324375261 cites W2169045601 @default.
• W4324375261 cites W2171678183 @default.
• W4324375261 cites W2220215167 @default.
• W4324375261 cites W2410375143 @default.
• W4324375261 cites W2462121348 @default.
• W4324375261 cites W2589879570 @default.
• W4324375261 cites W2595863515 @default.
• W4324375261 cites W2598516816 @default.
• W4324375261 cites W2768591361 @default.
• W4324375261 cites W2790591041 @default.
• W4324375261 cites W2796584001 @default.
• W4324375261 cites W2802219516 @default.
• W4324375261 cites W2883858361 @default.
• W4324375261 cites W2902480770 @default.
• W4324375261 cites W2945788231 @default.
• W4324375261 cites W2961217357 @default.
• W4324375261 cites W2971594652 @default.
• W4324375261 cites W3000897567 @default.
• W4324375261 cites W3004501396 @default.
• W4324375261 cites W3009898868 @default.
• W4324375261 cites W3035540747 @default.
• W4324375261 cites W3038351796 @default.
• W4324375261 cites W3083923472 @default.
• W4324375261 cites W3097646670 @default.
• W4324375261 cites W3116538731 @default.
• W4324375261 cites W3127739024 @default.
• W4324375261 cites W3128868608 @default.
• W4324375261 cites W3135468099 @default.
• W4324375261 cites W3154431974 @default.
• W4324375261 cites W3174246647 @default.
• W4324375261 cites W3177404930 @default.
• W4324375261 cites W3193942139 @default.
• W4324375261 cites W3195584820 @default.
• W4324375261 cites W3216412747 @default.
• W4324375261 cites W4213096603 @default.
• W4324375261 cites W4225584265 @default.
• W4324375261 cites W4253193856 @default.
• W4324375261 cites W4280579995 @default.
• W4324375261 doi "https://doi.org/10.3389/fimmu.2023.1128151" @default.
• W4324375261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37006287" @default.
• W4324375261 hasPublicationYear "2023" @default.
• W4324375261 type Work @default.
• W4324375261 citedByCount "0" @default.
• W4324375261 crossrefType "journal-article" @default.
• W4324375261 hasAuthorship W4324375261A5002450016 @default.
• W4324375261 hasAuthorship W4324375261A5012664679 @default.
• W4324375261 hasAuthorship W4324375261A5018652999 @default.
• W4324375261 hasAuthorship W4324375261A5058723416 @default.
• W4324375261 hasAuthorship W4324375261A5083503582 @default.
• W4324375261 hasAuthorship W4324375261A5091018084 @default.
• W4324375261 hasBestOaLocation W43243752611 @default.
• W4324375261 hasConcept C104317684 @default.
• W4324375261 hasConcept C121608353 @default.
• W4324375261 hasConcept C203014093 @default.
• W4324375261 hasConcept C2776107976 @default.
• W4324375261 hasConcept C2778227246 @default.
• W4324375261 hasConcept C2779013556 @default.
• W4324375261 hasConcept C2779399171 @default.
• W4324375261 hasConcept C2780394083 @default.
• W4324375261 hasConcept C2781197716 @default.
• W4324375261 hasConcept C41091548 @default.
• W4324375261 hasConcept C502942594 @default.
• W4324375261 hasConcept C54355233 @default.
• W4324375261 hasConcept C71924100 @default.
• W4324375261 hasConcept C86803240 @default.
• W4324375261 hasConcept C8891405 @default.
• W4324375261 hasConceptScore W4324375261C104317684 @default.
• W4324375261 hasConceptScore W4324375261C121608353 @default.
• W4324375261 hasConceptScore W4324375261C203014093 @default.
• W4324375261 hasConceptScore W4324375261C2776107976 @default.
• W4324375261 hasConceptScore W4324375261C2778227246 @default.
• W4324375261 hasConceptScore W4324375261C2779013556 @default.
• W4324375261 hasConceptScore W4324375261C2779399171 @default.

• next