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- W4324376032 abstract "Abstract During early stages of human large ribosomal subunit (60 S ) biogenesis, an ensemble of assembly factors establishes and fine-tunes the essential RNA functional centers of pre-60 S particles by an unknown mechanism. Here, we report a series of cryo-electron microscopy structures of human nucleolar and nuclear pre-60 S assembly intermediates at resolutions of 2.5-3.2 Å. These structures show how protein interaction hubs tether assembly factor complexes to nucleolar particles and how GTPases and ATPases couple irreversible nucleotide hydrolysis steps to the installation of functional centers. Nuclear stages highlight how a conserved RNA processing complex, the rixosome, couples large-scale RNA conformational changes to pre-rRNA processing by the RNA degradation machinery. Our ensemble of human pre-60 S particles provides a rich foundation to elucidate the molecular principles of ribosome formation. One-Sentence Summary High-resolution cryo-EM structures of human pre-60S particles reveal new principles of eukaryotic ribosome assembly." @default.
- W4324376032 created "2023-03-16" @default.
- W4324376032 creator A5031074465 @default.
- W4324376032 creator A5036579138 @default.
- W4324376032 date "2023-03-14" @default.
- W4324376032 modified "2023-10-14" @default.
- W4324376032 title "Principles of human pre-60<i>S</i>biogenesis" @default.
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- W4324376032 doi "https://doi.org/10.1101/2023.03.14.532478" @default.
- W4324376032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36993238" @default.
- W4324376032 hasPublicationYear "2023" @default.
- W4324376032 type Work @default.