FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324378496> ?p ?o ?g. }

• W4324378496 abstract "HBV is one of the most widespread hepatitis viruses worldwide, and a correlation between chronic infection and liver cancer has been clearly reported. The carcinogenic capacity of HBV has been reported for other solid tumors, but the largest number of studies focus on its possible lymphomagenic role. To update the correlation between HBV infection and the occurrence of lymphatic or hematologic malignancies, the most recent evidence from epidemiological and in vitro studies has been reported. In the context of hematological malignancies, the strongest epidemiological correlations are with the emergence of lymphomas, in particular non-Hodgkin’s lymphoma (NHL) (HR 2.10 [95% CI 1.34-3.31], p=0.001) and, more specifically, all NHL B subtypes (HR 2.14 [95% CI 1.61-2.07], p&lt;0.001). Questionable and unconfirmed associations are reported between HBV and NHL T subtypes (HR 1.11 [95% CI 0.88-1.40], p=0.40) and leukemia. The presence of HBV DNA in peripheral blood mononuclear cells has been reported by numerous studies, and its integration in the exonic regions of some genes is considered a possible source of carcinogenesis. Some in vitro studies have shown the ability of HBV to infect, albeit not productively, both lymphomonocytes and bone marrow stem cells, whose differentiation is halted by the virus. As demonstrated in animal models, HBV infection of blood cells and the persistence of HBV DNA in peripheral lymphomonocytes and bone marrow stem cells suggests that these cellular compartments may act as HBV reservoirs, allowing replication to resume later in the immunocompromised patients (such as liver transplant recipients) or in subjects discontinuing effective antiviral therapy. The pathogenetic mechanisms at the basis of HBV carcinogenic potential are not known, and more in-depth studies are needed, considering that a clear correlation between chronic HBV infection and hematological malignancies could benefit both antiviral drugs and vaccines." @default.
• W4324378496 created "2023-03-16" @default.
• W4324378496 creator A5008602531 @default.
• W4324378496 creator A5020412439 @default.
• W4324378496 creator A5049875479 @default.
• W4324378496 creator A5053423077 @default.
• W4324378496 creator A5057710917 @default.
• W4324378496 creator A5062194333 @default.
• W4324378496 creator A5080225362 @default.
• W4324378496 date "2023-03-15" @default.
• W4324378496 modified "2023-10-14" @default.
• W4324378496 title "New insights into hepatitis B virus lymphotropism: Implications for HBV-related lymphomagenesis" @default.
• W4324378496 cites W1515539841 @default.
• W4324378496 cites W1523170992 @default.
• W4324378496 cites W1525415532 @default.
• W4324378496 cites W1563075736 @default.
• W4324378496 cites W1564362601 @default.
• W4324378496 cites W1595200385 @default.
• W4324378496 cites W1607458830 @default.
• W4324378496 cites W1642879362 @default.
• W4324378496 cites W1956749639 @default.
• W4324378496 cites W1964330972 @default.
• W4324378496 cites W1966119018 @default.
• W4324378496 cites W1969093502 @default.
• W4324378496 cites W1972685032 @default.
• W4324378496 cites W1973915759 @default.
• W4324378496 cites W1974970634 @default.
• W4324378496 cites W1976179286 @default.
• W4324378496 cites W1976724744 @default.
• W4324378496 cites W1986073312 @default.
• W4324378496 cites W1994712098 @default.
• W4324378496 cites W1995171299 @default.
• W4324378496 cites W1995503310 @default.
• W4324378496 cites W1996208830 @default.
• W4324378496 cites W1998638459 @default.
• W4324378496 cites W1999337265 @default.
• W4324378496 cites W2001976371 @default.
• W4324378496 cites W2005900025 @default.
• W4324378496 cites W2013954429 @default.
• W4324378496 cites W2015113497 @default.
• W4324378496 cites W2015414255 @default.
• W4324378496 cites W2021065971 @default.
• W4324378496 cites W2024570495 @default.
• W4324378496 cites W2031730698 @default.
• W4324378496 cites W2032455812 @default.
• W4324378496 cites W2035051556 @default.
• W4324378496 cites W2045023726 @default.
• W4324378496 cites W2050115670 @default.
• W4324378496 cites W2051028678 @default.
• W4324378496 cites W2060534398 @default.
• W4324378496 cites W2063847769 @default.
• W4324378496 cites W2064294645 @default.
• W4324378496 cites W2064414653 @default.
• W4324378496 cites W2065558544 @default.
• W4324378496 cites W2071168599 @default.
• W4324378496 cites W2075794196 @default.
• W4324378496 cites W2075991572 @default.
• W4324378496 cites W2076238787 @default.
• W4324378496 cites W2076659776 @default.
• W4324378496 cites W2077606460 @default.
• W4324378496 cites W2080054391 @default.
• W4324378496 cites W2088599718 @default.
• W4324378496 cites W2090679050 @default.
• W4324378496 cites W2096668059 @default.
• W4324378496 cites W2101049127 @default.
• W4324378496 cites W2106167636 @default.
• W4324378496 cites W2118230692 @default.
• W4324378496 cites W2123389370 @default.
• W4324378496 cites W2123513460 @default.
• W4324378496 cites W2123774331 @default.
• W4324378496 cites W2124911741 @default.
• W4324378496 cites W2136599675 @default.
• W4324378496 cites W2151682201 @default.
• W4324378496 cites W2153044868 @default.
• W4324378496 cites W2158240321 @default.
• W4324378496 cites W2164383394 @default.
• W4324378496 cites W2166206937 @default.
• W4324378496 cites W2344715720 @default.
• W4324378496 cites W2397087191 @default.
• W4324378496 cites W2529771496 @default.
• W4324378496 cites W2551611384 @default.
• W4324378496 cites W2604429837 @default.
• W4324378496 cites W2605785536 @default.
• W4324378496 cites W2739683242 @default.
• W4324378496 cites W2769948690 @default.
• W4324378496 cites W2773273689 @default.
• W4324378496 cites W2803367030 @default.
• W4324378496 cites W2946569511 @default.
• W4324378496 cites W2949565907 @default.
• W4324378496 cites W2969293842 @default.
• W4324378496 cites W3010259006 @default.
• W4324378496 cites W3022103309 @default.
• W4324378496 cites W3087969031 @default.
• W4324378496 cites W3092515320 @default.
• W4324378496 cites W3101072197 @default.
• W4324378496 cites W3127136442 @default.
• W4324378496 cites W3165310526 @default.
• W4324378496 cites W3185401483 @default.
• W4324378496 cites W3192932777 @default.
• W4324378496 cites W3196125726 @default.

• next