Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324382105> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4324382105 abstract "Abstract The m6A modification is a methylation of the adenosine N6 position, is a kind of reversible post-transcriptional modification of RNA. Moreover, this process has been shown to be associated with multiple tumor progression. Prostate cancer is the second most common cancer in men after lung cancer, and is closely related to m6A. However, previous studies were often limited to a few m6A related genes, and failed to fully understand the relationship between prostate cancer and m6A.Therefore, we used the CIBERSORT and ESTIMATE algorithms to define three m6A clusters based on the expression of m6A-related genes in 1099 PC patients. Subsequently, we identified three different m6A gene clusters based on the overlap of differentially expressed genes (DEGs) within the m6A clusters. In addition, by principal component analysis (PCA) was performed to calculate the m6A scores. The results showed that patients with high m6A scores had longer survival time and those with low scores had shorter survival time. Furthermore, the m6A score was negatively correlated with the tumor mutation burden (TMB) value of PC. Patients with higher m6A scores showed clinical benefit and advantage of immunotherapy, indicating that the m6A score is an accurate and valid predictor to assess the effect of immunotherapy. Overall, our study presents a new method for reference that can provide guidance for current immunotherapy and predict patient prognosis to help physicians make judgments about patient disease and treatment modalities, and can guide current research on immunotherapy strategies for PC." @default.
- W4324382105 created "2023-03-16" @default.
- W4324382105 creator A5005392252 @default.
- W4324382105 creator A5018144808 @default.
- W4324382105 creator A5035354175 @default.
- W4324382105 creator A5051072389 @default.
- W4324382105 creator A5058176906 @default.
- W4324382105 creator A5061498333 @default.
- W4324382105 creator A5064003251 @default.
- W4324382105 creator A5066831817 @default.
- W4324382105 creator A5081754197 @default.
- W4324382105 creator A5088432923 @default.
- W4324382105 creator A5089282308 @default.
- W4324382105 date "2023-03-15" @default.
- W4324382105 modified "2023-09-27" @default.
- W4324382105 title "An N6-methyladenosine-Related Classification Predicts Prognosis and Response to Immunotherapy in Prostate cancer" @default.
- W4324382105 doi "https://doi.org/10.21203/rs.3.rs-2661691/v1" @default.
- W4324382105 hasPublicationYear "2023" @default.
- W4324382105 type Work @default.
- W4324382105 citedByCount "0" @default.
- W4324382105 crossrefType "posted-content" @default.
- W4324382105 hasAuthorship W4324382105A5005392252 @default.
- W4324382105 hasAuthorship W4324382105A5018144808 @default.
- W4324382105 hasAuthorship W4324382105A5035354175 @default.
- W4324382105 hasAuthorship W4324382105A5051072389 @default.
- W4324382105 hasAuthorship W4324382105A5058176906 @default.
- W4324382105 hasAuthorship W4324382105A5061498333 @default.
- W4324382105 hasAuthorship W4324382105A5064003251 @default.
- W4324382105 hasAuthorship W4324382105A5066831817 @default.
- W4324382105 hasAuthorship W4324382105A5081754197 @default.
- W4324382105 hasAuthorship W4324382105A5088432923 @default.
- W4324382105 hasAuthorship W4324382105A5089282308 @default.
- W4324382105 hasBestOaLocation W43243821051 @default.
- W4324382105 hasConcept C121608353 @default.
- W4324382105 hasConcept C126322002 @default.
- W4324382105 hasConcept C143998085 @default.
- W4324382105 hasConcept C2776256026 @default.
- W4324382105 hasConcept C2777701055 @default.
- W4324382105 hasConcept C2779134260 @default.
- W4324382105 hasConcept C2780192828 @default.
- W4324382105 hasConcept C60644358 @default.
- W4324382105 hasConcept C71924100 @default.
- W4324382105 hasConcept C86803240 @default.
- W4324382105 hasConceptScore W4324382105C121608353 @default.
- W4324382105 hasConceptScore W4324382105C126322002 @default.
- W4324382105 hasConceptScore W4324382105C143998085 @default.
- W4324382105 hasConceptScore W4324382105C2776256026 @default.
- W4324382105 hasConceptScore W4324382105C2777701055 @default.
- W4324382105 hasConceptScore W4324382105C2779134260 @default.
- W4324382105 hasConceptScore W4324382105C2780192828 @default.
- W4324382105 hasConceptScore W4324382105C60644358 @default.
- W4324382105 hasConceptScore W4324382105C71924100 @default.
- W4324382105 hasConceptScore W4324382105C86803240 @default.
- W4324382105 hasLocation W43243821051 @default.
- W4324382105 hasOpenAccess W4324382105 @default.
- W4324382105 hasPrimaryLocation W43243821051 @default.
- W4324382105 hasRelatedWork W1899936169 @default.
- W4324382105 hasRelatedWork W2009226744 @default.
- W4324382105 hasRelatedWork W2031697966 @default.
- W4324382105 hasRelatedWork W2528840586 @default.
- W4324382105 hasRelatedWork W2762580124 @default.
- W4324382105 hasRelatedWork W3137670083 @default.
- W4324382105 hasRelatedWork W3171615116 @default.
- W4324382105 hasRelatedWork W3184088343 @default.
- W4324382105 hasRelatedWork W3217115064 @default.
- W4324382105 hasRelatedWork W4308769187 @default.
- W4324382105 isParatext "false" @default.
- W4324382105 isRetracted "false" @default.
- W4324382105 workType "article" @default.