FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324382680> ?p ?o ?g. }

• W4324382680 endingPage "5593" @default.
• W4324382680 startingPage "5593" @default.
• W4324382680 abstract "Huntington's disease (HD) is a progressive neurodegenerative disease characterized by mutations in the huntingtin gene (mHtt), causing an unstable repeat of the CAG trinucleotide, leading to abnormal long repeats of polyglutamine (poly-Q) in the N-terminal region of the huntingtin, which form abnormal conformations and aggregates. Alterations in Ca2+ signaling are involved in HD models and the accumulation of mutated huntingtin interferes with Ca2+ homeostasis. Lysosomes are intracellular Ca2+ storages that participate in endocytic and lysosomal degradation processes, including autophagy. Nicotinic acid adenine dinucleotide phosphate (NAADP) is an intracellular second messenger that promotes Ca2+ release from the endo-lysosomal system via Two-Pore Channels (TPCs) activation. Herein, we show the impact of lysosomal Ca2+ signals on mHtt aggregation and autophagy blockade in murine astrocytes overexpressing mHtt-Q74. We observed that mHtt-Q74 overexpression causes an increase in NAADP-evoked Ca2+ signals and mHtt aggregation, which was inhibited in the presence of Ned-19, a TPC antagonist, or BAPTA-AM, a Ca2+ chelator. Additionally, TPC2 silencing revert the mHtt aggregation. Furthermore, mHtt has been shown co-localized with TPC2 which may contribute to its effects on lysosomal homeostasis. Moreover, NAADP-mediated autophagy was also blocked since its function is dependent on lysosomal functionality. Taken together, our data show that increased levels of cytosolic Ca2+ mediated by NAADP causes mHtt aggregation. Additionally, mHtt co-localizes with the lysosomes, where it possibly affects organelle functions and impairs autophagy." @default.
• W4324382680 created "2023-03-16" @default.
• W4324382680 creator A5001000307 @default.
• W4324382680 creator A5023900503 @default.
• W4324382680 creator A5036125335 @default.
• W4324382680 creator A5050710377 @default.
• W4324382680 creator A5052583753 @default.
• W4324382680 creator A5054119713 @default.
• W4324382680 creator A5055234275 @default.
• W4324382680 creator A5060981226 @default.
• W4324382680 creator A5061120781 @default.
• W4324382680 date "2023-03-15" @default.
• W4324382680 modified "2023-10-15" @default.
• W4324382680 title "NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes" @default.
• W4324382680 cites W1484276963 @default.
• W4324382680 cites W1528977425 @default.
• W4324382680 cites W153349786 @default.
• W4324382680 cites W1562797648 @default.
• W4324382680 cites W1607531254 @default.
• W4324382680 cites W1803199265 @default.
• W4324382680 cites W1964549513 @default.
• W4324382680 cites W1975832881 @default.
• W4324382680 cites W1984394485 @default.
• W4324382680 cites W1987064331 @default.
• W4324382680 cites W2002311914 @default.
• W4324382680 cites W2007066406 @default.
• W4324382680 cites W2009370459 @default.
• W4324382680 cites W2015426350 @default.
• W4324382680 cites W2017593971 @default.
• W4324382680 cites W2031675835 @default.
• W4324382680 cites W2031790758 @default.
• W4324382680 cites W2052047416 @default.
• W4324382680 cites W2055435187 @default.
• W4324382680 cites W2057095204 @default.
• W4324382680 cites W2071453130 @default.
• W4324382680 cites W2077499130 @default.
• W4324382680 cites W2081802283 @default.
• W4324382680 cites W2084636668 @default.
• W4324382680 cites W2087157508 @default.
• W4324382680 cites W2096905204 @default.
• W4324382680 cites W2112045725 @default.
• W4324382680 cites W2113413121 @default.
• W4324382680 cites W2114999674 @default.
• W4324382680 cites W2118546680 @default.
• W4324382680 cites W2121642311 @default.
• W4324382680 cites W2127088485 @default.
• W4324382680 cites W2127463580 @default.
• W4324382680 cites W2154682365 @default.
• W4324382680 cites W2154778779 @default.
• W4324382680 cites W2187516654 @default.
• W4324382680 cites W2291779372 @default.
• W4324382680 cites W2307837122 @default.
• W4324382680 cites W2552601588 @default.
• W4324382680 cites W2559796913 @default.
• W4324382680 cites W2562542977 @default.
• W4324382680 cites W2603755504 @default.
• W4324382680 cites W2613425063 @default.
• W4324382680 cites W2620745816 @default.
• W4324382680 cites W2727054874 @default.
• W4324382680 cites W2749718288 @default.
• W4324382680 cites W2752775217 @default.
• W4324382680 cites W2790491367 @default.
• W4324382680 cites W2790859162 @default.
• W4324382680 cites W2796209740 @default.
• W4324382680 cites W2884073029 @default.
• W4324382680 cites W2888481567 @default.
• W4324382680 cites W2991329979 @default.
• W4324382680 cites W3156330991 @default.
• W4324382680 cites W3197752561 @default.
• W4324382680 cites W4200463812 @default.
• W4324382680 cites W69881358 @default.
• W4324382680 doi "https://doi.org/10.3390/ijms24065593" @default.
• W4324382680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36982672" @default.
• W4324382680 hasPublicationYear "2023" @default.
• W4324382680 type Work @default.
• W4324382680 citedByCount "3" @default.
• W4324382680 countsByYear W43243826802023 @default.
• W4324382680 crossrefType "journal-article" @default.
• W4324382680 hasAuthorship W4324382680A5001000307 @default.
• W4324382680 hasAuthorship W4324382680A5023900503 @default.
• W4324382680 hasAuthorship W4324382680A5036125335 @default.
• W4324382680 hasAuthorship W4324382680A5050710377 @default.
• W4324382680 hasAuthorship W4324382680A5052583753 @default.
• W4324382680 hasAuthorship W4324382680A5054119713 @default.
• W4324382680 hasAuthorship W4324382680A5055234275 @default.
• W4324382680 hasAuthorship W4324382680A5060981226 @default.
• W4324382680 hasAuthorship W4324382680A5061120781 @default.
• W4324382680 hasBestOaLocation W43243826801 @default.
• W4324382680 hasConcept C104317684 @default.
• W4324382680 hasConcept C143065580 @default.
• W4324382680 hasConcept C181199279 @default.
• W4324382680 hasConcept C185592680 @default.
• W4324382680 hasConcept C190283241 @default.
• W4324382680 hasConcept C203522944 @default.
• W4324382680 hasConcept C2780216420 @default.
• W4324382680 hasConcept C2781427258 @default.
• W4324382680 hasConcept C2910011555 @default.
• W4324382680 hasConcept C55493867 @default.

• next