Matches in SemOpenAlex for { <https://semopenalex.org/work/W4324383789> ?p ?o ?g. }
- W4324383789 endingPage "943" @default.
- W4324383789 startingPage "943" @default.
- W4324383789 abstract "Inducing immunogenic cell death (ICD) during cancer therapy is a major challenge that might significantly improve patient survival. The purpose of this study was to develop a theranostic nanocarrier, capable both of conveying a cytotoxic thermal dose when mediating photothermal therapy (PTT) after its intravenous delivery, and of consequently inducing ICD, improving survival. The nanocarrier consists of red blood cell membranes (RBCm) embedding the near-infrared dye IR-780 (IR) and camouflaging Mn-ferrite nanoparticles (RBCm-IR-Mn). The RBCm-IR-Mn nanocarriers were characterized by size, morphology, surface charge, magnetic, photophysical, and photothermal properties. Their photothermal conversion efficiency was found to be size- and concentration-dependent. Late apoptosis was observed as the cell death mechanism for PTT. Calreticulin and HMGB1 protein levels increased for in vitro PTT with temperature around 55 °C (ablative regime) but not for 44 °C (hyperthermia), suggesting ICD elicitation under ablation. RBCm-IR-Mn were then intravenously administered in sarcoma S180-bearing Swiss mice, and in vivo ablative PTT was performed five days later. Tumor volumes were monitored for the subsequent 120 days. RBCm-IR-Mn-mediated PTT promoted tumor regression in 11/12 animals, with an overall survival rate of 85% (11/13). Our results demonstrate that the RBCm-IR-Mn nanocarriers are great candidates for PTT-induced cancer immunotherapy." @default.
- W4324383789 created "2023-03-16" @default.
- W4324383789 creator A5002052031 @default.
- W4324383789 creator A5027091657 @default.
- W4324383789 creator A5028657022 @default.
- W4324383789 creator A5029094584 @default.
- W4324383789 creator A5046363417 @default.
- W4324383789 creator A5050297977 @default.
- W4324383789 creator A5067138124 @default.
- W4324383789 creator A5067671511 @default.
- W4324383789 creator A5078403212 @default.
- W4324383789 creator A5080298948 @default.
- W4324383789 creator A5081941536 @default.
- W4324383789 creator A5082324447 @default.
- W4324383789 date "2023-03-14" @default.
- W4324383789 modified "2023-10-14" @default.
- W4324383789 title "Immunogenic Cell Death Photothermally Mediated by Erythrocyte Membrane-Coated Magnetofluorescent Nanocarriers Improves Survival in Sarcoma Model" @default.
- W4324383789 cites W1980257336 @default.
- W4324383789 cites W1985712964 @default.
- W4324383789 cites W2000314257 @default.
- W4324383789 cites W2005804168 @default.
- W4324383789 cites W2007933892 @default.
- W4324383789 cites W2036890691 @default.
- W4324383789 cites W2062629617 @default.
- W4324383789 cites W2063470712 @default.
- W4324383789 cites W2137816700 @default.
- W4324383789 cites W2144908002 @default.
- W4324383789 cites W2145479354 @default.
- W4324383789 cites W2159592868 @default.
- W4324383789 cites W2291205197 @default.
- W4324383789 cites W2296997375 @default.
- W4324383789 cites W2316603021 @default.
- W4324383789 cites W2319524180 @default.
- W4324383789 cites W2376997792 @default.
- W4324383789 cites W2385742822 @default.
- W4324383789 cites W2593852474 @default.
- W4324383789 cites W2595944375 @default.
- W4324383789 cites W2799899978 @default.
- W4324383789 cites W2803598967 @default.
- W4324383789 cites W2884188691 @default.
- W4324383789 cites W2901809167 @default.
- W4324383789 cites W3002355380 @default.
- W4324383789 cites W3008263983 @default.
- W4324383789 cites W3023768187 @default.
- W4324383789 cites W3032478635 @default.
- W4324383789 cites W3042896632 @default.
- W4324383789 cites W3118715035 @default.
- W4324383789 cites W3119492490 @default.
- W4324383789 cites W3126926449 @default.
- W4324383789 cites W3192233809 @default.
- W4324383789 cites W3217799976 @default.
- W4324383789 cites W4200148704 @default.
- W4324383789 cites W4220704568 @default.
- W4324383789 cites W4244033773 @default.
- W4324383789 cites W4290839670 @default.
- W4324383789 cites W4304185311 @default.
- W4324383789 cites W4307475977 @default.
- W4324383789 cites W4318480160 @default.
- W4324383789 doi "https://doi.org/10.3390/pharmaceutics15030943" @default.
- W4324383789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36986804" @default.
- W4324383789 hasPublicationYear "2023" @default.
- W4324383789 type Work @default.
- W4324383789 citedByCount "0" @default.
- W4324383789 crossrefType "journal-article" @default.
- W4324383789 hasAuthorship W4324383789A5002052031 @default.
- W4324383789 hasAuthorship W4324383789A5027091657 @default.
- W4324383789 hasAuthorship W4324383789A5028657022 @default.
- W4324383789 hasAuthorship W4324383789A5029094584 @default.
- W4324383789 hasAuthorship W4324383789A5046363417 @default.
- W4324383789 hasAuthorship W4324383789A5050297977 @default.
- W4324383789 hasAuthorship W4324383789A5067138124 @default.
- W4324383789 hasAuthorship W4324383789A5067671511 @default.
- W4324383789 hasAuthorship W4324383789A5078403212 @default.
- W4324383789 hasAuthorship W4324383789A5080298948 @default.
- W4324383789 hasAuthorship W4324383789A5081941536 @default.
- W4324383789 hasAuthorship W4324383789A5082324447 @default.
- W4324383789 hasBestOaLocation W43243837891 @default.
- W4324383789 hasConcept C12554922 @default.
- W4324383789 hasConcept C126322002 @default.
- W4324383789 hasConcept C158617107 @default.
- W4324383789 hasConcept C171250308 @default.
- W4324383789 hasConcept C178790620 @default.
- W4324383789 hasConcept C18150654 @default.
- W4324383789 hasConcept C182606246 @default.
- W4324383789 hasConcept C185592680 @default.
- W4324383789 hasConcept C190283241 @default.
- W4324383789 hasConcept C192562407 @default.
- W4324383789 hasConcept C2777877232 @default.
- W4324383789 hasConcept C2779820397 @default.
- W4324383789 hasConcept C2779949491 @default.
- W4324383789 hasConcept C31573885 @default.
- W4324383789 hasConcept C47450691 @default.
- W4324383789 hasConcept C502942594 @default.
- W4324383789 hasConcept C55493867 @default.
- W4324383789 hasConcept C71924100 @default.
- W4324383789 hasConcept C86803240 @default.
- W4324383789 hasConceptScore W4324383789C12554922 @default.
- W4324383789 hasConceptScore W4324383789C126322002 @default.