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- W43245000 abstract "The honey bee contains a Dl-like receptor, AmBAR6 (Apis mellifera Biogenic Amine Receptor 6), which is characterised (in this thesis) in terms of its function, structure, phylogeny, and pharmacology. Dopamine is known to be a behaviourally important neuromodulator in all animals. The honey bee, because of its reproductive and temporal division of labour and extensive repertoire of activities is ideal for molecular behavioural studies. For this reason experiments were designed to measure AmBAR6 gene expression with respect to age, sex, and behavioural caste. In addition the affect of stress and flight deprivation on AmBAR6 gene expression was determined. The gene structure, predicted protein structure, and phylogenetic analyses revealed that AmBAR6 is a dopamine receptor related to, but distinct from, the vertebrate and invertebrate D1 receptors. In situ hybridisation to mRNA in whole mount preparations of honey bee brains revealed distinct patterns of expression of AmBAR6 in two anatomically distinguishable cell types in the mushroom bodies (the integration and memoiy centre of the brain). In honey bees of all castes (reproductives and workers) the receptor gene is strongly and constitutively expressed in all small cell-bodied intemeurones (Kenyon cells) of the mushroom bodies. In contrast, the large cell-bodied intemeurones, which constitute the remainder of the Kenyon cells, exhibit dramatic plasticity of AmBAR6 gene expression correlated with age. An age-dependent expression pattern of the AmBAR6 protein is seen in the neuropil of the mushroom bodies and in the central complex (a structure involved in interhemisphere coordination of neuronal activity as well as motor output). The correlation between receptorexpression and age was further investigated by uncoupling the effects of age and behaviour on gene expression. It was determined that even though specific behaviours were not required for the age-dependent increase in receptor expression, both behaviour and stress can influence the magnitude of gene expression. In this thesis it is proposed that AmBAR6 functions in normal development of the insect sensorimotor system and it prepares honey bees for progressively more complex behaviours such as foraging and flight." @default.
- W43245000 created "2016-06-24" @default.
- W43245000 creator A5070054443 @default.
- W43245000 date "2019-09-08" @default.
- W43245000 modified "2023-09-26" @default.
- W43245000 title "Characterisation of a unique dopamine receptor in honey bees: Structure, phylogeny, pharmacology and function" @default.
- W43245000 doi "https://doi.org/10.14264/uql.2019.715" @default.
- W43245000 hasPublicationYear "2019" @default.
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