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- W43267697 abstract "Publisher Summary This chapter presents the in vitro studies of the functional differentiation of mammary gland. Extensive application of culture methods to the mammary gland began in the 1950s. At this stage, cultured tissue could only effectively be studied histologically but two key observations were made. First, the explants of the ventral body wall of 10-day-old mouse embryos showed differentiation of the mammary bud in vitro. This observation led to a series of very elegant experiments on early mammary gland development in mice, rats, and rabbits and on the role of mesenchyme as an inducer and also as a target tissue for testosterone in sexual differentiation of the mouse mammary gland. Mammary tissue can be successfully explanted and respond to hormones at most stages of its development, but tissue already lactating when explanted is very hard to maintain in organ culture. This may be due in part to its high metabolic rate and the inadequacy of diffusion rather than a capillary blood supply to cope with exchange." @default.
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- W43267697 date "1981-01-01" @default.
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- W43267697 title "IN VITRO STUDIES OF THE FUNCTIONAL DIFFERENTIATION OF MAMMARY GLAND" @default.
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- W43267697 doi "https://doi.org/10.1016/b978-0-08-027341-9.50027-x" @default.
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