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- W4327494020 abstract "Summary We evaluated the utility of the PFA-100® platelet function analyzer in identifying disorders in platelet function and/or von Willebrand factor (vWF) in patients with various systemic disorders being followed at a tertiary care center. Closure times were determined with collagen/ ADP (CADP) and collagen/epinephrine (CEPI) cartridges for 305 patients, and abnormal results were further evaluated with platelet aggregometry and vWF analysis. Prolonged CADP and/or CEPI closure times were identified in 114 patients (37.3%), but most were isolated prolonged CEPI closure times predominantly due to aspirin therapy (79 patients). Prolonged CADP closure times were most frequently due to qualitative platelet defects and/or decreased vWF levels. Prolonged CADP closure times were encountered most frequently in patients with sickle cell disease and were associated with a decreased hematocrit. This study demonstrated that the PFA-100® analyzer can accurately assess vWF-dependent platelet function and detect other platelet defects under high shear stress in complex patient populations." @default.
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- W4327494020 date "2000-01-01" @default.
- W4327494020 modified "2023-09-26" @default.
- W4327494020 title "Assessment of Primary Hemostasis by PFA-100® Analysis in a Tertiary Care Center" @default.
- W4327494020 doi "https://doi.org/10.1055/s-0037-1613974" @default.
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