FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327518467> ?p ?o ?g. }

• W4327518467 abstract "Plasmalogens (Pls), a special group of phospholipids, are effective in ameliorating neurodegenerative disease. In the present study, the metabolic effects of seafood-derived Pls on high fat diet (HFD)-induced hyperlipidemia in zebrafish were evaluated, and the underlying mechanisms of dietary Pls against hyperlipidemia were explored through integrated analyses of hepatic transcriptomics and metabolomics. The results demonstrated that Pls supplementation could effectively alleviate HFD-induced obesity symptoms, such as body weight gain, and decrease total hepatic cholesterol and triglyceride levels. Integrated hepatic transcriptome and metabolome data suggested that Pls mainly altered lipid metabolism pathways (FA metabolism, primary bile acid biosynthesis, steroid hormone biosynthesis, and glycerolipid and glycerophospholipid metabolism) and the TCA cycle, induced the overexpression of anti-oxidation enzymes (Cat, Gpx4, Sod3a and Xdh), reduced disease biomarkers (such as glutarylcarnitine, gamma-glutamyltyrosine, and 11-prostaglandin f2) and gut microbiota-derived metabolites, and increased (±)12(13)-diHOME, EPA, lysoPC and PC levels. Moreover, 5 abnormally regulated metabolites were identified as potential biomarkers associated with hyperlipidemia according to the metabolomics results and suggested the involvement of gut microbiota in the anti-hyperlipidemic effects of Pls. Collectively, these findings suggest that the protective role of Pls is mainly associated with the promotion of unsaturated fatty acid biosynthesis and cholesterol efflux, lipid and phospholipid PUFA remodeling, and anti-oxidation and anti-inflammatory capabilities. This study provides valuable information for reasonably explaining the beneficial effects of seafood-derived Pls in alleviating hyperlipidemia and thus may contribute to the development and application of Pls as functional foods or dietary supplements to protect against obesity and hyperlipidemia." @default.
• W4327518467 created "2023-03-17" @default.
• W4327518467 creator A5003183751 @default.
• W4327518467 creator A5005663184 @default.
• W4327518467 creator A5008171524 @default.
• W4327518467 creator A5011622715 @default.
• W4327518467 creator A5040303257 @default.
• W4327518467 creator A5063980678 @default.
• W4327518467 creator A5071373383 @default.
• W4327518467 date "2023-01-01" @default.
• W4327518467 modified "2023-09-23" @default.
• W4327518467 title "Transcriptomics integrated with metabolomics reveals the ameliorating effect of mussel-derived plasmalogens on high-fat diet-induced hyperlipidemia in zebrafish" @default.
• W4327518467 cites W1964027278 @default.
• W4327518467 cites W2021404912 @default.
• W4327518467 cites W2080582253 @default.
• W4327518467 cites W2147683217 @default.
• W4327518467 cites W2173701799 @default.
• W4327518467 cites W2179239886 @default.
• W4327518467 cites W2569732255 @default.
• W4327518467 cites W2598787075 @default.
• W4327518467 cites W2604288015 @default.
• W4327518467 cites W2734770034 @default.
• W4327518467 cites W2744290711 @default.
• W4327518467 cites W2751936835 @default.
• W4327518467 cites W2779885767 @default.
• W4327518467 cites W2794410137 @default.
• W4327518467 cites W2803843936 @default.
• W4327518467 cites W2808488256 @default.
• W4327518467 cites W2810080142 @default.
• W4327518467 cites W2885323999 @default.
• W4327518467 cites W2889780886 @default.
• W4327518467 cites W2892510821 @default.
• W4327518467 cites W2912100707 @default.
• W4327518467 cites W2912465744 @default.
• W4327518467 cites W2938566604 @default.
• W4327518467 cites W2950260552 @default.
• W4327518467 cites W2956101246 @default.
• W4327518467 cites W2959826626 @default.
• W4327518467 cites W2969523838 @default.
• W4327518467 cites W2969949554 @default.
• W4327518467 cites W2970536524 @default.
• W4327518467 cites W2981499784 @default.
• W4327518467 cites W2988141055 @default.
• W4327518467 cites W2999854125 @default.
• W4327518467 cites W3004227146 @default.
• W4327518467 cites W3004412088 @default.
• W4327518467 cites W3010214800 @default.
• W4327518467 cites W3047439922 @default.
• W4327518467 cites W3085758172 @default.
• W4327518467 cites W3092867985 @default.
• W4327518467 cites W3095139271 @default.
• W4327518467 cites W3118577024 @default.
• W4327518467 cites W3119738945 @default.
• W4327518467 cites W3125044263 @default.
• W4327518467 cites W3137665829 @default.
• W4327518467 cites W3153867501 @default.
• W4327518467 cites W3161445211 @default.
• W4327518467 cites W3173638043 @default.
• W4327518467 cites W3204639004 @default.
• W4327518467 cites W3206727976 @default.
• W4327518467 cites W3208548737 @default.
• W4327518467 cites W3211344099 @default.
• W4327518467 cites W3211379521 @default.
• W4327518467 cites W3217776969 @default.
• W4327518467 cites W4206506198 @default.
• W4327518467 cites W4206972726 @default.
• W4327518467 cites W4289943119 @default.
• W4327518467 doi "https://doi.org/10.1039/d3fo00063j" @default.
• W4327518467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36961308" @default.
• W4327518467 hasPublicationYear "2023" @default.
• W4327518467 type Work @default.
• W4327518467 citedByCount "0" @default.
• W4327518467 crossrefType "journal-article" @default.
• W4327518467 hasAuthorship W4327518467A5003183751 @default.
• W4327518467 hasAuthorship W4327518467A5005663184 @default.
• W4327518467 hasAuthorship W4327518467A5008171524 @default.
• W4327518467 hasAuthorship W4327518467A5011622715 @default.
• W4327518467 hasAuthorship W4327518467A5040303257 @default.
• W4327518467 hasAuthorship W4327518467A5063980678 @default.
• W4327518467 hasAuthorship W4327518467A5071373383 @default.
• W4327518467 hasConcept C104317684 @default.
• W4327518467 hasConcept C134018914 @default.
• W4327518467 hasConcept C135870905 @default.
• W4327518467 hasConcept C150194340 @default.
• W4327518467 hasConcept C162317418 @default.
• W4327518467 hasConcept C185592680 @default.
• W4327518467 hasConcept C192989942 @default.
• W4327518467 hasConcept C21565614 @default.
• W4327518467 hasConcept C2776952329 @default.
• W4327518467 hasConcept C2776991927 @default.
• W4327518467 hasConcept C2778918659 @default.
• W4327518467 hasConcept C2779091943 @default.
• W4327518467 hasConcept C41625074 @default.
• W4327518467 hasConcept C4733338 @default.
• W4327518467 hasConcept C55493867 @default.
• W4327518467 hasConcept C555293320 @default.
• W4327518467 hasConcept C60644358 @default.
• W4327518467 hasConcept C62231903 @default.
• W4327518467 hasConcept C86803240 @default.
• W4327518467 hasConceptScore W4327518467C104317684 @default.

• next