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• W4327559547 endingPage "121655" @default.
• W4327559547 startingPage "121655" @default.
• W4327559547 abstract "The infections caused by bacteria that are resistant to drugs are very bad for human health and kill thousands of people every year. Also, both human actions and natural processes make surface waters more likely to have drug-resistant bacteria grow and spread in the environment. Because of this, researchers need to find new ways to treat bacterial infections quickly becoming resistant to drugs as soon as possible. Drug delivery systems based on nanoparticles have enhanced biocompatibility, biocidal properties, pharmacokinetics, tumor targeting, and stability while exhibiting non-toxicity to normal cells and overcoming drug resistance. In the present work, the pluronic-F127 encapsulated titanium dioxide (PF127/TiO2) nanoparticles (NPs) were prepared by a green process using Morinda citrifolia leaf extract. X-ray diffraction patterns (XRD) revealed that synthesized NPs exhibit an anatase structure. FESEM and TEM images of synthesized PF127/TiO2 NPs showed a polymorphic structure and an average particle size of 50–60 nm. The chemical composition of the prepared NPs, which included elements like carbon, titanium, and oxygen, was identified using the EDAX spectrum. With the DLS spectrum, the hydrodynamic sizes of PF127/TiO2 NPs were 176 nm. In the FTIR spectrum, the metal oxide stretching bands like O-Ti-O were located at 664 cm−1 for PF127/TiO2 NPs. The surface defects, including Ti and O vacancies, were studied using the photoluminescence spectrum. The prepared PF127/TiO2 NPs exhibited significant microbial activity for inhibiting hospital pathogenic bacterial and fungal strains, specifically (Staphylococcus aureus) S. aureus, (Streptococcus pneumoniae) S. pneumonia, (Klebsiella pneumoniae) K. pneumonia, (Shigella dysenteriae) S. dysenteriae and (Candida albicans) C. albicans. In addition, PF127/TiO2 NPs had highly anti-cancer properties against human blood cancer (MOLT-4) cell lines. Furthermore, we found that synthesized PF127/TiO2 NPs exhibited anti-inflammatory activity." @default.
• W4327559547 created "2023-03-17" @default.
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• W4327559547 date "2023-06-01" @default.
• W4327559547 modified "2023-10-06" @default.
• W4327559547 title "Pluronic f127 encapsulated titanium dioxide nanoparticles: Evaluation of physiochemical properties for biological applications" @default.
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• W4327559547 doi "https://doi.org/10.1016/j.molliq.2023.121655" @default.
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