FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327571781> ?p ?o ?g. }

• W4327571781 endingPage "108383" @default.
• W4327571781 startingPage "108383" @default.
• W4327571781 abstract "Animal models are fundamental to advance our knowledge of the underlying pathophysiology of bone loss and to study pharmaceutical countermeasures against it. The animal model of post-menopausal osteoporosis from ovariectomy is the most widely used preclinical approach to study skeletal deterioration. However, several other animal models exist, each with unique characteristics such as bone loss from disuse, lactation, glucocorticoid excess, or exposure to hypobaric hypoxia. The present review aimed to provide a comprehensive overview of these animal models to emphasize the importance and significance of investigating bone loss and pharmaceutical countermeasures from perspectives other than post-menopausal osteoporosis only. Hence, the pathophysiology and underlying cellular mechanisms involved in the various types of bone loss are different, and this might influence which prevention and treatment strategies are the most effective. In addition, the review sought to map the current landscape of pharmaceutical countermeasures against osteoporosis with an emphasis on how drug development has changed from being driven by clinical observations and enhancement or repurposing of existing drugs to today's use of targeted anti-bodies that are the result of advanced insights into the underlying molecular mechanisms of bone formation and resorption. Moreover, new treatment combinations or repurposing opportunities of already approved drugs with a focus on dabigatran, parathyroid hormone and abaloparatide, growth hormone, inhibitors of the activin signaling pathway, acetazolamide, zoledronate, and romosozumab are discussed. Despite the considerable progress in drug development, there is still a clear need to improve treatment strategies and develop new pharmaceuticals against various types of osteoporosis. The review also highlights that new treatment indications should be explored using multiple animal models of bone loss in order to ensure a broad representation of different types of skeletal deterioration instead of mainly focusing on primary osteoporosis from post-menopausal estrogen deficiency." @default.
• W4327571781 created "2023-03-17" @default.
• W4327571781 creator A5050294155 @default.
• W4327571781 date "2023-04-01" @default.
• W4327571781 modified "2023-09-30" @default.
• W4327571781 title "Pharmaceutical treatment of bone loss: From animal models and drug development to future treatment strategies" @default.
• W4327571781 cites W1000149840 @default.
• W4327571781 cites W117344629 @default.
• W4327571781 cites W1425165754 @default.
• W4327571781 cites W1499045657 @default.
• W4327571781 cites W1513928844 @default.
• W4327571781 cites W1521138540 @default.
• W4327571781 cites W1526826623 @default.
• W4327571781 cites W1534981615 @default.
• W4327571781 cites W1566734997 @default.
• W4327571781 cites W1594526962 @default.
• W4327571781 cites W1599204041 @default.
• W4327571781 cites W1608000030 @default.
• W4327571781 cites W1644079882 @default.
• W4327571781 cites W1727491712 @default.
• W4327571781 cites W172839501 @default.
• W4327571781 cites W1827006191 @default.
• W4327571781 cites W1855705762 @default.
• W4327571781 cites W1861752754 @default.
• W4327571781 cites W1870080799 @default.
• W4327571781 cites W1875731610 @default.
• W4327571781 cites W1896801189 @default.
• W4327571781 cites W1913863467 @default.
• W4327571781 cites W1950074323 @default.
• W4327571781 cites W1952470036 @default.
• W4327571781 cites W1964454575 @default.
• W4327571781 cites W1964474592 @default.
• W4327571781 cites W1964908330 @default.
• W4327571781 cites W1965174761 @default.
• W4327571781 cites W1965358752 @default.
• W4327571781 cites W1967502057 @default.
• W4327571781 cites W1968077365 @default.
• W4327571781 cites W1968418396 @default.
• W4327571781 cites W1968491544 @default.
• W4327571781 cites W1968771860 @default.
• W4327571781 cites W1969453145 @default.
• W4327571781 cites W1970210484 @default.
• W4327571781 cites W1972688815 @default.
• W4327571781 cites W1973451979 @default.
• W4327571781 cites W1974996403 @default.
• W4327571781 cites W1975825361 @default.
• W4327571781 cites W1976299751 @default.
• W4327571781 cites W1977681194 @default.
• W4327571781 cites W1977950302 @default.
• W4327571781 cites W1978536896 @default.
• W4327571781 cites W1979043688 @default.
• W4327571781 cites W1979270237 @default.
• W4327571781 cites W1979529284 @default.
• W4327571781 cites W1980418071 @default.
• W4327571781 cites W1981063888 @default.
• W4327571781 cites W1982395713 @default.
• W4327571781 cites W1984126393 @default.
• W4327571781 cites W1985158740 @default.
• W4327571781 cites W1985177716 @default.
• W4327571781 cites W1985380766 @default.
• W4327571781 cites W1986145457 @default.
• W4327571781 cites W1986214667 @default.
• W4327571781 cites W1986258020 @default.
• W4327571781 cites W1986371480 @default.
• W4327571781 cites W1987176983 @default.
• W4327571781 cites W1987375682 @default.
• W4327571781 cites W1987576187 @default.
• W4327571781 cites W1987697677 @default.
• W4327571781 cites W1988188057 @default.
• W4327571781 cites W1988240171 @default.
• W4327571781 cites W1988420415 @default.
• W4327571781 cites W1989553857 @default.
• W4327571781 cites W1992084468 @default.
• W4327571781 cites W1992929199 @default.
• W4327571781 cites W1993035292 @default.
• W4327571781 cites W1993231839 @default.
• W4327571781 cites W1994313426 @default.
• W4327571781 cites W1994414479 @default.
• W4327571781 cites W1994417406 @default.
• W4327571781 cites W1994518372 @default.
• W4327571781 cites W1995090061 @default.
• W4327571781 cites W1995181362 @default.
• W4327571781 cites W1995251672 @default.
• W4327571781 cites W1996596881 @default.
• W4327571781 cites W1997810509 @default.
• W4327571781 cites W1997849708 @default.
• W4327571781 cites W1998946842 @default.
• W4327571781 cites W1999209028 @default.
• W4327571781 cites W1999242737 @default.
• W4327571781 cites W2000746306 @default.
• W4327571781 cites W2001291592 @default.
• W4327571781 cites W2001785768 @default.
• W4327571781 cites W2002315967 @default.
• W4327571781 cites W2002481407 @default.
• W4327571781 cites W2002677585 @default.
• W4327571781 cites W2004496677 @default.
• W4327571781 cites W2006063113 @default.
• W4327571781 cites W2006629115 @default.

• next