FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327571804> ?p ?o ?g. }

• W4327571804 endingPage "111050" @default.
• W4327571804 startingPage "111050" @default.
• W4327571804 abstract "Prostate cancer is the most common cancer, excluding skin cancer, diagnosed among men in the US. Autopsy studies confirm the high prevalence of indolent prostate cancers starting in the third decade of life. There are lifestyle and therapeutic factors that might be facilitating the transformation of indolent to high-grade cancers throughout life. Prostate-specific membrane antigen (PSMA) is a transmembrane protein that is highly expressed on prostate cancer cells and has diagnostic, prognostic and therapeutic implications. Emerging evidence has elucidated many of its biologic functions, including folate acquisition from the gut, transporting unmetabolized circulating folic acid into prostate cancer cells, involvement in physiologic and neoplastic angiogenesis and redirecting cell survival signaling pathways. Folates are utilized by the prostate for various aspects of reproductive biology. Synthetic oxidized folic acid has been used in grain and cereal fortification in the US since 1998; as a result, folate levels have more than doubled, and most individuals exhibit unmetabolized folic acid in the circulation. In fact, folic acid from fortified foods and supplements is the main driver of folate levels in the population. However, folic acid is a double-edged sword and can support nucleotide synthesis and prostate cancer cell proliferation. As such, the promotion of high-grade prostate cancer by folic acid, but not natural folates, has been evidenced in prospective trials. Ironically, androgen deprivation therapy (ADT), used in the treatment of prostate cancer, leads to increases in both PSMA expression and folate levels. Therefore, we hypothesize that avoiding folic acid intake from fortified foods and supplements will decrease the risk of high-grade prostate cancer and decrease prostate cancer progression, particularly among men undergoing treatment with ADT. Moreover, the nexus of PSMA, folic acid, androgen modulation and high-grade prostate cancer is discussed, along with practical and therapeutic implications. Finally, questions are raised which should spur interest in research that might translate into a reduction in high-grade prostate cancer." @default.
• W4327571804 created "2023-03-17" @default.
• W4327571804 creator A5005297335 @default.
• W4327571804 creator A5007710677 @default.
• W4327571804 date "2023-05-01" @default.
• W4327571804 modified "2023-10-16" @default.
• W4327571804 title "Prostate-specific membrane antigen (PSMA), androgen modulation, folic acid, and high-grade prostate cancer: An intriguing nexus needing attention" @default.
• W4327571804 cites W1536737482 @default.
• W4327571804 cites W1550830253 @default.
• W4327571804 cites W1840167048 @default.
• W4327571804 cites W2059149893 @default.
• W4327571804 cites W2110016941 @default.
• W4327571804 cites W2123901759 @default.
• W4327571804 cites W2124296003 @default.
• W4327571804 cites W2131054574 @default.
• W4327571804 cites W2131221314 @default.
• W4327571804 cites W2138743737 @default.
• W4327571804 cites W2155530804 @default.
• W4327571804 cites W2169495321 @default.
• W4327571804 cites W2220225661 @default.
• W4327571804 cites W2334889994 @default.
• W4327571804 cites W2496194097 @default.
• W4327571804 cites W2530447877 @default.
• W4327571804 cites W2595075592 @default.
• W4327571804 cites W2757976464 @default.
• W4327571804 cites W2766290717 @default.
• W4327571804 cites W2769219206 @default.
• W4327571804 cites W2791186815 @default.
• W4327571804 cites W2801600457 @default.
• W4327571804 cites W2807646053 @default.
• W4327571804 cites W2896820763 @default.
• W4327571804 cites W2906327585 @default.
• W4327571804 cites W2972649385 @default.
• W4327571804 cites W2981509235 @default.
• W4327571804 cites W3027615824 @default.
• W4327571804 cites W3092029533 @default.
• W4327571804 cites W3135529189 @default.
• W4327571804 cites W3163408842 @default.
• W4327571804 cites W3173275598 @default.
• W4327571804 cites W3174575855 @default.
• W4327571804 cites W3178588825 @default.
• W4327571804 cites W4206841660 @default.
• W4327571804 cites W4210424128 @default.
• W4327571804 cites W4214536398 @default.
• W4327571804 cites W4280557713 @default.
• W4327571804 cites W4280565236 @default.
• W4327571804 cites W4362207783 @default.
• W4327571804 doi "https://doi.org/10.1016/j.mehy.2023.111050" @default.
• W4327571804 hasPublicationYear "2023" @default.
• W4327571804 type Work @default.
• W4327571804 citedByCount "0" @default.
• W4327571804 crossrefType "journal-article" @default.
• W4327571804 hasAuthorship W4327571804A5005297335 @default.
• W4327571804 hasAuthorship W4327571804A5007710677 @default.
• W4327571804 hasConcept C121608353 @default.
• W4327571804 hasConcept C126322002 @default.
• W4327571804 hasConcept C143998085 @default.
• W4327571804 hasConcept C2776235491 @default.
• W4327571804 hasConcept C2780192828 @default.
• W4327571804 hasConcept C2908647359 @default.
• W4327571804 hasConcept C502942594 @default.
• W4327571804 hasConcept C71924100 @default.
• W4327571804 hasConcept C99454951 @default.
• W4327571804 hasConceptScore W4327571804C121608353 @default.
• W4327571804 hasConceptScore W4327571804C126322002 @default.
• W4327571804 hasConceptScore W4327571804C143998085 @default.
• W4327571804 hasConceptScore W4327571804C2776235491 @default.
• W4327571804 hasConceptScore W4327571804C2780192828 @default.
• W4327571804 hasConceptScore W4327571804C2908647359 @default.
• W4327571804 hasConceptScore W4327571804C502942594 @default.
• W4327571804 hasConceptScore W4327571804C71924100 @default.
• W4327571804 hasConceptScore W4327571804C99454951 @default.
• W4327571804 hasLocation W43275718041 @default.
• W4327571804 hasOpenAccess W4327571804 @default.
• W4327571804 hasPrimaryLocation W43275718041 @default.
• W4327571804 hasRelatedWork W131936546 @default.
• W4327571804 hasRelatedWork W1497253641 @default.
• W4327571804 hasRelatedWork W1980245127 @default.
• W4327571804 hasRelatedWork W2060381175 @default.
• W4327571804 hasRelatedWork W2075763133 @default.
• W4327571804 hasRelatedWork W2088520467 @default.
• W4327571804 hasRelatedWork W2376423713 @default.
• W4327571804 hasRelatedWork W2386364393 @default.
• W4327571804 hasRelatedWork W2400504790 @default.
• W4327571804 hasRelatedWork W3032731309 @default.
• W4327571804 hasVolume "174" @default.
• W4327571804 isParatext "false" @default.
• W4327571804 isRetracted "false" @default.
• W4327571804 workType "article" @default.