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- W4327571805 abstract "Abstract Diverse bacterial species produce extracellular contractile injection systems (eCISs). Although closely related to contractile phage tails, eCISs can inject toxic proteins into eukaryotic cells. Thus, these systems are commonly viewed as cytotoxic defense mechanisms that are not central to other aspects of bacterial biology. Here, we provide evidence that eCISs appear to participate in the complex developmental process of the bacterium Streptomyces coelicolor . In particular, we show that S. coelicolor produces eCIS particles during its normal growth cycle, and that strains lacking functional eCIS particles exhibit pronounced alterations in their developmental program. Furthermore, eCIS-deficient mutants display reduced levels of cell death and altered morphology during growth in liquid media. Our results suggest that the main role of eCISs in S. coelicolor is to modulate the developmental switch that leads to aerial hyphae formation and sporulation, rather than to attack other species." @default.
- W4327571805 created "2023-03-17" @default.
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- W4327571805 date "2023-03-16" @default.
- W4327571805 modified "2023-10-16" @default.
- W4327571805 title "A contractile injection system is required for developmentally regulated cell death in Streptomyces coelicolor" @default.
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- W4327571805 doi "https://doi.org/10.1038/s41467-023-37087-7" @default.
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