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• W4327572216 abstract "Gastroparesis and functional dyspepsia (FD) are 2 common sensorimotor disorders in the gastroduodenal region, and the distinction between both has been a matter of ongoing debate. 1 Stanghellini V. Tack J. Gastroparesis: separate entity or just a part of dyspepsia?. Gut. 2014; 63: 1972-1978 Crossref PubMed Scopus (104) Google Scholar The overlap in symptoms between gastroparesis and FD, especially postprandial distress syndrome, is well established. 2 Parkman H.P. Yates K. Hasler W.L. et al. National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium. Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. Gastroenterology. 2011; 140: 101-115 Abstract Full Text Full Text PDF PubMed Scopus (235) Google Scholar In addition, patients with gastroparesis frequently present with symptoms of avoidant or restrictive food intake disorder, 3 Burton Murray H. Jehangir A. Silvernale C.J. Kuo B. Parkman H.P. Avoidant/restrictive food intake disorder symptoms are frequent in patients presenting for symptoms of gastroparesis. Neurogastroenterol Motil. 2020; 32e13931 Crossref PubMed Scopus (33) Google Scholar and patients with eating disorders may have objectively delayed gastric emptying. 4 Heruc G.A. Little T.J. Kohn M.R. et al. Effects of starvation and short-term refeeding on gastric emptying and postprandial blood glucose regulation in adolescent girls with anorexia nervosa. Am J Physiol Endocrinol Metab. 2018; 315: E565-E573 Crossref PubMed Scopus (26) Google Scholar The correlation between retardation of gastric emptying and symptoms is imperfect, either at baseline, during the gastric-emptying measurement, or in response to prokinetic therapy, 2 Parkman H.P. Yates K. Hasler W.L. et al. National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium. Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. Gastroenterology. 2011; 140: 101-115 Abstract Full Text Full Text PDF PubMed Scopus (235) Google Scholar ,5 Sarnelli G. Caenepeel P. Geypens B. Janssens J. Tack J. Symptoms associated with delayed emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol. 2003; 98: 783-788 Crossref PubMed Scopus (418) Google Scholar , 6 Janssen P. Harris M.S. Jones M. et al. The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis. Am J Gastroenterol. 2013; 108: 1382-1391 Crossref PubMed Scopus (186) Google Scholar , 7 Vijayvargiya P. Jameie-Oskooei S. Camilleri M. Chedid V. Erwin P.J. Murad M.H. Association between delayed gastric emptying and upper gastrointestinal symptoms: a systematic review and metaanalysis. Gut. 2019; 68: 804-813 Crossref PubMed Scopus (112) Google Scholar , 8 Vijayvargiya P. Camilleri M. Chedid V. Mandawat A. Erwin P.J. Murad M.H. Effects of promotility agents on gastric emptying and symptoms: a systematic review and meta-analysis. Gastroenterology. 2019; 156: 1650-1660 Abstract Full Text Full Text PDF PubMed Scopus (90) Google Scholar , 9 Chakraborty S. Desai A. Halland M. et al. Relationship between symptoms during a gastric emptying study and intestinal chemosensitivity with daily symptoms. Neurogastroenterol Motil. 2019; 31e13686 Crossref Scopus (13) Google Scholar and significant intraindividual variation is present in the measured gastric emptying of solids, whether measured using scintigraphy or stable isotope measurements. 10 Camilleri M. Iturrino J. Bharucha A.E. et al. Performance characteristics of scintigraphic measurement of gastric emptying of solids in healthy participants. Neurogastroenterol Motil. 2012; 241076-e562 Crossref Scopus (120) Google Scholar , 11 Desai A. O'Connor M. Neja B. et al. Reproducibility of gastric emptying assessed with scintigraphy in patients with upper GI symptoms. Neurogastroenterol Motil. 2018; 30e13365 Crossref PubMed Scopus (26) Google Scholar , 12 Choi M.G. Camilleri M. Burton D.D. Zinsmeister A.R. Forstrom L.A. Nair K.S. Reproducibility and simplification of 13C-octanoic acid breath test for gastric emptying of solids. Am J Gastroenterol. 1998; 93: 92-98 Crossref PubMed Scopus (123) Google Scholar , 13 Choi M.G. Camilleri M. Burton D.D. Zinsmeister A.R. Forstrom L.A. Nair K.S. [13C]octanoic acid breath test for gastric emptying of solids: accuracy, reproducibility, and comparison with scintigraphy. Gastroenterology. 1997; 112: 1155-1162 Abstract Full Text PDF PubMed Scopus (182) Google Scholar This variation was also documented in 41% of 249 patients with upper gastrointestinal symptoms studied in the National Institutes of Health–National Institute of Diabetes and Digestive and Kidney Diseases gastroparesis consortium follow-up cohort on 2 occasions 48 weeks apart. 14 Pasricha P.J. Grover M. Yates K.P. et al. Functional dyspepsia and gastroparesis in tertiary care are interchangeable syndromes with common clinical and pathologic features. Gastroenterology. 2021; 160: 2006-2017 Abstract Full Text Full Text PDF PubMed Scopus (77) Google Scholar Seventy-nine of 189 patients with delayed gastric emptying at baseline normalized (<10% retained at 4 hours) at 48 weeks, and 22 of 60 patients with normal emptying at baseline had delayed gastric emptying (>10% retained at 4 hours) at 48 weeks. 14 Pasricha P.J. Grover M. Yates K.P. et al. Functional dyspepsia and gastroparesis in tertiary care are interchangeable syndromes with common clinical and pathologic features. Gastroenterology. 2021; 160: 2006-2017 Abstract Full Text Full Text PDF PubMed Scopus (77) Google Scholar" @default.
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• W4327572216 title "Is the Quantification of Interstitial Cells of Cajal in Gastric Biopsy Samples in Patients With Gastroparesis Ready for Prime Time?" @default.
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