FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327591665> ?p ?o ?g. }

• W4327591665 endingPage "395" @default.
• W4327591665 startingPage "381" @default.
• W4327591665 abstract "Cognitive operations including pre-attentive sensory processing are markedly impaired in patients with schizophrenia (SCZ) but evidence significant interindividual heterogeneity, which moderates treatment response with nicotinic acetylcholine receptor (nAChR) agonists. Previous studies in healthy volunteers have shown baseline-dependency effects of the α7 nAChR agonist cytidine 5'-diphosphocholine (CDP-choline) administered alone and in combination with a nicotinic allosteric modulator (galantamine) on auditory deviance detection measured with the mismatch negativity (MMN) event-related potential (ERP).The objective of this pilot study was to assess the acute effect of this combined α7 nAChR-targeted treatment (CDP-choline/galantamine) on speech MMN in patients with SCZ (N = 24) stratified by baseline MMN responses into low, medium, and high baseline auditory deviance detection subgroups.Patients with a stable diagnosis of SCZ attended two randomized, double-blind, placebo-controlled and counter-balanced testing sessions where they received a placebo or a CDP-choline (500 mg) and galantamine (16 mg) treatment. MMN ERPs were recorded during the presentation of a fast multi-feature speech MMN paradigm including five speech deviants. Clinical measures were acquired before and after treatment administration.While no main treatment effect was observed, CDP-choline/galantamine significantly increased MMN amplitudes to frequency, duration, and vowel speech deviants in low group individuals. Individuals with higher positive and negative symptom scale negative, general, and total scores expressed the greatest MMN amplitude improvement following CDP-choline/galantamine.These baseline-dependent nicotinic effects on early auditory information processing warrant different dosage and repeated administration assessments in patients with low baseline deviance detection levels." @default.
• W4327591665 created "2023-03-17" @default.
• W4327591665 creator A5007415215 @default.
• W4327591665 creator A5020059850 @default.
• W4327591665 creator A5037323059 @default.
• W4327591665 creator A5052102785 @default.
• W4327591665 creator A5062184570 @default.
• W4327591665 creator A5069276916 @default.
• W4327591665 creator A5079596491 @default.
• W4327591665 date "2023-03-16" @default.
• W4327591665 modified "2023-09-25" @default.
• W4327591665 title "An α7 nAChR approach for the baseline-dependent modulation of deviance detection in schizophrenia: A pilot study assessing the combined effect of CDP-choline and galantamine" @default.
• W4327591665 cites W1129581376 @default.
• W4327591665 cites W1510973950 @default.
• W4327591665 cites W1521700621 @default.
• W4327591665 cites W1531750674 @default.
• W4327591665 cites W1590457702 @default.
• W4327591665 cites W1595198448 @default.
• W4327591665 cites W1743806054 @default.
• W4327591665 cites W1808500773 @default.
• W4327591665 cites W1965103769 @default.
• W4327591665 cites W1970393142 @default.
• W4327591665 cites W1973081620 @default.
• W4327591665 cites W1974444901 @default.
• W4327591665 cites W1980748511 @default.
• W4327591665 cites W1981359380 @default.
• W4327591665 cites W1982109789 @default.
• W4327591665 cites W1984323006 @default.
• W4327591665 cites W1986682925 @default.
• W4327591665 cites W1987336202 @default.
• W4327591665 cites W1996141026 @default.
• W4327591665 cites W2001627614 @default.
• W4327591665 cites W2004540176 @default.
• W4327591665 cites W2005627203 @default.
• W4327591665 cites W2007002607 @default.
• W4327591665 cites W2014781736 @default.
• W4327591665 cites W2016810174 @default.
• W4327591665 cites W2017221160 @default.
• W4327591665 cites W2022587387 @default.
• W4327591665 cites W2025080131 @default.
• W4327591665 cites W2028562300 @default.
• W4327591665 cites W2030243202 @default.
• W4327591665 cites W2037256337 @default.
• W4327591665 cites W2038198089 @default.
• W4327591665 cites W2038670995 @default.
• W4327591665 cites W2038763083 @default.
• W4327591665 cites W2039182468 @default.
• W4327591665 cites W2039714278 @default.
• W4327591665 cites W2043674960 @default.
• W4327591665 cites W2047006920 @default.
• W4327591665 cites W2048154745 @default.
• W4327591665 cites W2048663957 @default.
• W4327591665 cites W2049328501 @default.
• W4327591665 cites W2054983612 @default.
• W4327591665 cites W2057320515 @default.
• W4327591665 cites W2060472216 @default.
• W4327591665 cites W2068473398 @default.
• W4327591665 cites W2070578932 @default.
• W4327591665 cites W2070961119 @default.
• W4327591665 cites W2072426002 @default.
• W4327591665 cites W2073905083 @default.
• W4327591665 cites W2076231092 @default.
• W4327591665 cites W2081800196 @default.
• W4327591665 cites W2085147467 @default.
• W4327591665 cites W2085407167 @default.
• W4327591665 cites W2090019512 @default.
• W4327591665 cites W2091478089 @default.
• W4327591665 cites W2091541963 @default.
• W4327591665 cites W2095162152 @default.
• W4327591665 cites W2095755860 @default.
• W4327591665 cites W2099058526 @default.
• W4327591665 cites W2104383152 @default.
• W4327591665 cites W2104619913 @default.
• W4327591665 cites W2106520995 @default.
• W4327591665 cites W2110613853 @default.
• W4327591665 cites W2112524106 @default.
• W4327591665 cites W2114512489 @default.
• W4327591665 cites W2122312681 @default.
• W4327591665 cites W2123703395 @default.
• W4327591665 cites W2125117208 @default.
• W4327591665 cites W2125206183 @default.
• W4327591665 cites W2125352026 @default.
• W4327591665 cites W2128638450 @default.
• W4327591665 cites W2136546688 @default.
• W4327591665 cites W2137010476 @default.
• W4327591665 cites W2139847356 @default.
• W4327591665 cites W2140009431 @default.
• W4327591665 cites W2140606211 @default.
• W4327591665 cites W2146290849 @default.
• W4327591665 cites W2151590986 @default.
• W4327591665 cites W2154183720 @default.
• W4327591665 cites W2155797616 @default.
• W4327591665 cites W2162327634 @default.
• W4327591665 cites W2165321423 @default.
• W4327591665 cites W2172485000 @default.
• W4327591665 cites W2173995149 @default.
• W4327591665 cites W2192994624 @default.
• W4327591665 cites W2213175826 @default.

• next