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• W4327597828 startingPage "467" @default.
• W4327597828 abstract "β-D-glucopyranosyloxymethiluracil (Base J) is a modified thymidine base found in kinetoplastids and some related organisms. Interestingly, Base J distribution into the genome can vary depending on the organism and its life stage. Base J is reported to be found mostly at telomeric repeats, on inactive variant surface glycoproteins (VSG's) expression sites (e.g., T. brucei), in RNA polymerase II termination sites and sub-telomeric regions (e.g., Leishmania). This hypermodified nucleotide is synthesized in two steps with the participation of two distinct thymidine hydroxylases, J-binding protein 1 and 2 (JBP1 and JBP2, respectively) and a β-glucosyl transferase. A third J-binding protein, named JBP3, was recently identified as part of a multimeric complex. Although its structural similarities with JBP1, it seems not to be involved in J biosynthesis but to play roles in gene expression regulation in trypanosomatids. Over the years, with the characterization of JBP1 and JBP2 mutant lines, Base J functions have been targeted and shone a light on that matter, showing genus-specific features. This review aims to explore Base J's reported participation as a regulator of RNA polymerase II transcription termination and to summarize the functional and structural characteristics and similarities of the remarkable JBP proteins in pathogenic trypanosomatids." @default.
• W4327597828 created "2023-03-17" @default.
• W4327597828 creator A5008397739 @default.
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• W4327597828 date "2023-03-16" @default.
• W4327597828 modified "2023-10-14" @default.
• W4327597828 title "Behind Base J: The Roles of JBP1 and JBP2 on Trypanosomatids" @default.
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• W4327597828 doi "https://doi.org/10.3390/pathogens12030467" @default.
• W4327597828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36986389" @default.
• W4327597828 hasPublicationYear "2023" @default.
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