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• W4327602305 startingPage "115284" @default.
• W4327602305 abstract "A series of diaryl heterocyclic analogues were designed and synthesized as tubulin polymerization inhibitors. Among them, compound 6y showed the highest antiproliferative activity against HCT-116 colon cancer cell line with an IC50 values of 2.65 μM. Compound 6y also effectively inhibited tubulin polymerization in vitro (IC50 of 10.9 μM), and induced HCT-116 cell cycle arrest in G2/M phase. In addition, compound 6y exhibited high metabolic stability on human liver microsomes (T1/2 = 106.2 min). Finally, 6y was also effective in suppressing tumor growth in a HCT-116 mouse colon model without apparent toxicity. Collectively, these results suggest that 6y represents a new class of tubulin inhibitors deserving further investigation." @default.
• W4327602305 created "2023-03-17" @default.
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• W4327602305 date "2023-04-01" @default.
• W4327602305 modified "2023-10-14" @default.
• W4327602305 title "Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities" @default.
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• W4327602305 doi "https://doi.org/10.1016/j.ejmech.2023.115284" @default.
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