Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327608424> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4327608424 endingPage "69" @default.
- W4327608424 startingPage "69" @default.
- W4327608424 abstract "INTRODUCTION: Limited treatment options exist for patients with chronic infarcts. Multipotent adult mesenchymal stem cells (MSC) show promise as a treatment for chronic stroke. Allogeneic MSCs have been implanted successfully in chronic stroke1,2. However, no literature evaluates the use of autologous MSCs delivered via stereotactic implantation. Autologous MSCs provide safety and accessibility benefits. METHODS: Male Sprague-Dawley rats underwent transient right MCAO for 120 minutes. Brain MRI and sensorimotor behavior were used to evaluate stroke. Sixteen days post stroke, tibial bone marrow was aspirated and MSCs were grown in a closed bioreactor. At 28 days post stroke, 3 trajectories of MSCs were implanted in the peri-infarct zone using a stereotactic robot. The treatments consisted of group 1 (5 x 106 cell dose, N = 6), group 2 (1 x 106 cell dose, N = 6) and a control group (saline injection, N = 9). In a second cohort of animals, Q-dot labeled autologous MSCs were tracked in the brain for 7 or 30 days. RESULTS: Behavior as determined by the modified neurological severity score (0-16) significantly improved in both groups. Stroke volume did not decrease. Histological analysis confirmed increased astrocyte and microglia presence in the affected hemisphere. Quantum dot analysis of injections showed presence of MSCs along trajectory as well as targeting perilesional brain tissue at 7 and 30 days post-implantation. CONCLUSIONS: Stereotactic injection of autologous MSCs represent an effective treatment for chronic stroke. Cells were effective at the lowest dose studied, with no added benefit at higher cell dosages. Unlike allogeneic MSCs which disappear over days to weeks3, autologous MSCs persist long term in the brain, potentially providing continued benefit. This treatment warrants human trials to study its effectiveness." @default.
- W4327608424 created "2023-03-17" @default.
- W4327608424 creator A5009235748 @default.
- W4327608424 creator A5020123913 @default.
- W4327608424 creator A5030396271 @default.
- W4327608424 creator A5030520665 @default.
- W4327608424 creator A5034571363 @default.
- W4327608424 creator A5046535003 @default.
- W4327608424 creator A5051627945 @default.
- W4327608424 creator A5065025351 @default.
- W4327608424 creator A5069301320 @default.
- W4327608424 date "2023-04-01" @default.
- W4327608424 modified "2023-09-26" @default.
- W4327608424 title "386 Stereotactic Implantation of Autologous Mesenchymal Stem Cells Improves Neurological Outcomes in a Rat Model of Chronic Middle Cerebral Artery Stroke" @default.
- W4327608424 doi "https://doi.org/10.1227/neu.0000000000002375_386" @default.
- W4327608424 hasPublicationYear "2023" @default.
- W4327608424 type Work @default.
- W4327608424 citedByCount "0" @default.
- W4327608424 crossrefType "journal-article" @default.
- W4327608424 hasAuthorship W4327608424A5009235748 @default.
- W4327608424 hasAuthorship W4327608424A5020123913 @default.
- W4327608424 hasAuthorship W4327608424A5030396271 @default.
- W4327608424 hasAuthorship W4327608424A5030520665 @default.
- W4327608424 hasAuthorship W4327608424A5034571363 @default.
- W4327608424 hasAuthorship W4327608424A5046535003 @default.
- W4327608424 hasAuthorship W4327608424A5051627945 @default.
- W4327608424 hasAuthorship W4327608424A5065025351 @default.
- W4327608424 hasAuthorship W4327608424A5069301320 @default.
- W4327608424 hasBestOaLocation W43276084241 @default.
- W4327608424 hasConcept C10882517 @default.
- W4327608424 hasConcept C126838900 @default.
- W4327608424 hasConcept C127413603 @default.
- W4327608424 hasConcept C141071460 @default.
- W4327608424 hasConcept C142724271 @default.
- W4327608424 hasConcept C143409427 @default.
- W4327608424 hasConcept C1862650 @default.
- W4327608424 hasConcept C198826908 @default.
- W4327608424 hasConcept C2776361831 @default.
- W4327608424 hasConcept C2778818304 @default.
- W4327608424 hasConcept C2780645631 @default.
- W4327608424 hasConcept C28328180 @default.
- W4327608424 hasConcept C54355233 @default.
- W4327608424 hasConcept C71924100 @default.
- W4327608424 hasConcept C78519656 @default.
- W4327608424 hasConcept C86803240 @default.
- W4327608424 hasConceptScore W4327608424C10882517 @default.
- W4327608424 hasConceptScore W4327608424C126838900 @default.
- W4327608424 hasConceptScore W4327608424C127413603 @default.
- W4327608424 hasConceptScore W4327608424C141071460 @default.
- W4327608424 hasConceptScore W4327608424C142724271 @default.
- W4327608424 hasConceptScore W4327608424C143409427 @default.
- W4327608424 hasConceptScore W4327608424C1862650 @default.
- W4327608424 hasConceptScore W4327608424C198826908 @default.
- W4327608424 hasConceptScore W4327608424C2776361831 @default.
- W4327608424 hasConceptScore W4327608424C2778818304 @default.
- W4327608424 hasConceptScore W4327608424C2780645631 @default.
- W4327608424 hasConceptScore W4327608424C28328180 @default.
- W4327608424 hasConceptScore W4327608424C54355233 @default.
- W4327608424 hasConceptScore W4327608424C71924100 @default.
- W4327608424 hasConceptScore W4327608424C78519656 @default.
- W4327608424 hasConceptScore W4327608424C86803240 @default.
- W4327608424 hasIssue "Supplement_1" @default.
- W4327608424 hasLocation W43276084241 @default.
- W4327608424 hasLocation W43276084242 @default.
- W4327608424 hasOpenAccess W4327608424 @default.
- W4327608424 hasPrimaryLocation W43276084241 @default.
- W4327608424 hasRelatedWork W2019295004 @default.
- W4327608424 hasRelatedWork W2080696419 @default.
- W4327608424 hasRelatedWork W2097452330 @default.
- W4327608424 hasRelatedWork W2113146603 @default.
- W4327608424 hasRelatedWork W2411636592 @default.
- W4327608424 hasRelatedWork W2919588678 @default.
- W4327608424 hasRelatedWork W2936107484 @default.
- W4327608424 hasRelatedWork W2946284807 @default.
- W4327608424 hasRelatedWork W3165406767 @default.
- W4327608424 hasRelatedWork W4312304759 @default.
- W4327608424 hasVolume "69" @default.
- W4327608424 isParatext "false" @default.
- W4327608424 isRetracted "false" @default.
- W4327608424 workType "article" @default.