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• W4327613105 abstract "Abstract Retrons are bacterial genetic retroelements that encode reverse transcriptase capable of producing multicopy single-stranded DNA (msDNA) and function as antiphage defense systems. Phages employ several strategies to counter the host defense systems, but no mechanisms for evading retrons are known. Here, we show that tRNA Tyr and Rad (retron anti-defense) of T5 phage family inhibit the defense activity of retron 78 and a broad range of retrons, respectively. The effector protein of retron 78, ptuAB, specifically degraded tRNA Tyr leading abortive infection, but phage countervailed this defense by supplying tRNA Tyr . Rad inhibited retron function by degrading noncoding RNA, the precursor of msDNA. In summary, we demonstrated that viruses encode at least two independent strategies for overcoming bacterial defense systems: anti-defense, such as Rad, and defense canceler, like tRNA." @default.
• W4327613105 created "2023-03-17" @default.
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• W4327613105 date "2023-03-15" @default.
• W4327613105 modified "2023-10-14" @default.
• W4327613105 title "Viruses encode tRNA and anti-retron to evade bacterial immunity" @default.
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• W4327613105 doi "https://doi.org/10.1101/2023.03.15.532788" @default.
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