Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327616651> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4327616651 abstract "Evidence on predictors of primary nonresponse (PNR), and secondary loss of response (SLR) to anti-tumor necrosis factor (anti-TNF) agents in inflammatory bowel disease is scarce from Asia. We evaluated clinical/biochemical/molecular markers of PNR/SLR in ulcerative colitis (UC) and Crohn's disease (CD).Inflammatory bowel disease patients treated with anti-TNF agents (January 2005-October 2020) were ambispectively included. Data concerning clinical and biochemical predictors was retrieved from a prospectively maintained database. Immunohistochemistry for expression of oncostatin M (OSM), OSM receptor (OSM-R), and interleukin-7 receptor (IL-7R) were done on pre anti-TNF initiation mucosal biopsies.One-hundred eighty-six patients (118 CD, 68 UC: mean age, 34.1±13.7 years; median disease duration at anti-TNF initiation, 60 months; interquartile range, 28-100.5 months) were included. PNR was seen in 17% and 26.5% and SLR in 47% and 28% CD and UC patients, respectively. In CD, predictors of PNR were low albumin (P<0.001), postoperative recurrence (P=0.001) and high IL-7R expression (P<0.027) on univariate; and low albumin alone (hazard ratio [HR], 0.09; 95% confidence interval [CI], 0.03-0.28; P<0.001) on multivariate analysis respectively. Low albumin (HR, 0.31; 95% CI, 0.15-0.62; P=0.001) also predicted SLR. In UC, predictors of PNR were low albumin (P<0.001), and high C-reactive protein (P<0.001), OSM (P<0.04) and OSM-R (P=0.07) stromal expression on univariate; and low albumin alone (HR, 0.11; 95% CI, 0.03-0.39; P=0.001) on multivariate analysis respectively.Low serum albumin at baseline significantly predicted PNR in UC and PNR/SLR in CD patients. Mucosal markers of PNR were high stromal OSM/OSM-R in UC and high IL-7R in CD patients." @default.
- W4327616651 created "2023-03-17" @default.
- W4327616651 creator A5001586106 @default.
- W4327616651 creator A5012286417 @default.
- W4327616651 creator A5015279222 @default.
- W4327616651 creator A5021129129 @default.
- W4327616651 creator A5024463062 @default.
- W4327616651 creator A5027608431 @default.
- W4327616651 creator A5035579463 @default.
- W4327616651 creator A5036227054 @default.
- W4327616651 creator A5036608684 @default.
- W4327616651 creator A5041958588 @default.
- W4327616651 creator A5051728486 @default.
- W4327616651 creator A5057745999 @default.
- W4327616651 creator A5058990589 @default.
- W4327616651 creator A5059852221 @default.
- W4327616651 creator A5062134833 @default.
- W4327616651 creator A5067513567 @default.
- W4327616651 creator A5075750110 @default.
- W4327616651 creator A5081287347 @default.
- W4327616651 creator A5083910516 @default.
- W4327616651 creator A5090247807 @default.
- W4327616651 date "2023-03-17" @default.
- W4327616651 modified "2023-10-14" @default.
- W4327616651 title "Serum albumin is the strongest predictor of anti-tumor necrosis factor nonresponse in inflammatory bowel disease in resource-constrained regions lacking therapeutic drug monitoring" @default.
- W4327616651 doi "https://doi.org/10.5217/ir.2022.00128" @default.
- W4327616651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36926698" @default.
- W4327616651 hasPublicationYear "2023" @default.
- W4327616651 type Work @default.
- W4327616651 citedByCount "1" @default.
- W4327616651 countsByYear W43276166512023 @default.
- W4327616651 crossrefType "journal-article" @default.
- W4327616651 hasAuthorship W4327616651A5001586106 @default.
- W4327616651 hasAuthorship W4327616651A5012286417 @default.
- W4327616651 hasAuthorship W4327616651A5015279222 @default.
- W4327616651 hasAuthorship W4327616651A5021129129 @default.
- W4327616651 hasAuthorship W4327616651A5024463062 @default.
- W4327616651 hasAuthorship W4327616651A5027608431 @default.
- W4327616651 hasAuthorship W4327616651A5035579463 @default.
- W4327616651 hasAuthorship W4327616651A5036227054 @default.
- W4327616651 hasAuthorship W4327616651A5036608684 @default.
- W4327616651 hasAuthorship W4327616651A5041958588 @default.
- W4327616651 hasAuthorship W4327616651A5051728486 @default.
- W4327616651 hasAuthorship W4327616651A5057745999 @default.
- W4327616651 hasAuthorship W4327616651A5058990589 @default.
- W4327616651 hasAuthorship W4327616651A5059852221 @default.
- W4327616651 hasAuthorship W4327616651A5062134833 @default.
- W4327616651 hasAuthorship W4327616651A5067513567 @default.
- W4327616651 hasAuthorship W4327616651A5075750110 @default.
- W4327616651 hasAuthorship W4327616651A5081287347 @default.
- W4327616651 hasAuthorship W4327616651A5083910516 @default.
- W4327616651 hasAuthorship W4327616651A5090247807 @default.
- W4327616651 hasBestOaLocation W43276166511 @default.
- W4327616651 hasConcept C119060515 @default.
- W4327616651 hasConcept C126322002 @default.
- W4327616651 hasConcept C144301174 @default.
- W4327616651 hasConcept C17991360 @default.
- W4327616651 hasConcept C207103383 @default.
- W4327616651 hasConcept C2776125364 @default.
- W4327616651 hasConcept C2778260677 @default.
- W4327616651 hasConcept C2779134260 @default.
- W4327616651 hasConcept C2780479503 @default.
- W4327616651 hasConcept C38180746 @default.
- W4327616651 hasConcept C44249647 @default.
- W4327616651 hasConcept C71924100 @default.
- W4327616651 hasConcept C90924648 @default.
- W4327616651 hasConceptScore W4327616651C119060515 @default.
- W4327616651 hasConceptScore W4327616651C126322002 @default.
- W4327616651 hasConceptScore W4327616651C144301174 @default.
- W4327616651 hasConceptScore W4327616651C17991360 @default.
- W4327616651 hasConceptScore W4327616651C207103383 @default.
- W4327616651 hasConceptScore W4327616651C2776125364 @default.
- W4327616651 hasConceptScore W4327616651C2778260677 @default.
- W4327616651 hasConceptScore W4327616651C2779134260 @default.
- W4327616651 hasConceptScore W4327616651C2780479503 @default.
- W4327616651 hasConceptScore W4327616651C38180746 @default.
- W4327616651 hasConceptScore W4327616651C44249647 @default.
- W4327616651 hasConceptScore W4327616651C71924100 @default.
- W4327616651 hasConceptScore W4327616651C90924648 @default.
- W4327616651 hasLocation W43276166511 @default.
- W4327616651 hasLocation W43276166512 @default.
- W4327616651 hasOpenAccess W4327616651 @default.
- W4327616651 hasPrimaryLocation W43276166511 @default.
- W4327616651 hasRelatedWork W1998231725 @default.
- W4327616651 hasRelatedWork W2070285775 @default.
- W4327616651 hasRelatedWork W2124908533 @default.
- W4327616651 hasRelatedWork W2258300052 @default.
- W4327616651 hasRelatedWork W2408939568 @default.
- W4327616651 hasRelatedWork W2418837291 @default.
- W4327616651 hasRelatedWork W2512626908 @default.
- W4327616651 hasRelatedWork W2947523721 @default.
- W4327616651 hasRelatedWork W3037194828 @default.
- W4327616651 hasRelatedWork W46359855 @default.
- W4327616651 isParatext "false" @default.
- W4327616651 isRetracted "false" @default.
- W4327616651 workType "article" @default.