FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327629219> ?p ?o ?g. }

• W4327629219 endingPage "101651" @default.
• W4327629219 startingPage "101651" @default.
• W4327629219 abstract "Exosomes act as essential modulators of cancer development and progression in hepatocellular carcinoma. However, little is known about the potential prognostic value and underlying molecular features of exosome-related long non-coding RNAs. Genes associated with exosome biogenesis, exosome secretion, and exosome biomarkers were collected. Exosome-related lncRNA modules were identified using PCA and WGCNA analysis. A prognostic model based on data from the TCGA, GEO, NODE, and ArrayExpress was developed and validated. A comprehensive analysis of the genomic landscape, functional annotation, immune profile, and therapeutic responses underlying the prognostic signature was performed on multi-omics data, and bioinformatics methods were also applied to predict potential drugs for patients with high risk scores. qRT-PCR was used to validate the differentially expressed lncRNAs in normal and cancer cell lines. Twenty-six hub lncRNAs were identified as highly correlated with exosomes and overall survival and were used for prognosis modeling. Three cohorts consistently showed higher scores in the high-risk group, with an AUC greater than 0.7 over time. These higher scores implied poorer overall survival, higher genomic instability, higher tumor purity, higher tumor stemness, pro-tumor pathway activation, lower anti-tumor immune cell and tertiary lymphoid structure infiltration, and poor responses to immune checkpoint blockade therapy and transarterial chemoembolization therapy. Through developing an exosome-related lncRNA predictor for HCC patients, we revealed the clinical relevance of exosome-related lncRNAs and their potential as prognostic biomarkers and therapeutic response predictors." @default.
• W4327629219 created "2023-03-17" @default.
• W4327629219 creator A5010490479 @default.
• W4327629219 creator A5017541508 @default.
• W4327629219 creator A5022948743 @default.
• W4327629219 creator A5035754451 @default.
• W4327629219 creator A5043374274 @default.
• W4327629219 creator A5062180989 @default.
• W4327629219 creator A5063278481 @default.
• W4327629219 creator A5076736269 @default.
• W4327629219 creator A5077232935 @default.
• W4327629219 creator A5083149235 @default.
• W4327629219 date "2023-05-01" @default.
• W4327629219 modified "2023-10-14" @default.
• W4327629219 title "An exosome-related lncRNA signature correlates with prognosis, immune microenvironment, and therapeutic responses in hepatocellular carcinoma" @default.
• W4327629219 cites W1984883254 @default.
• W4327629219 cites W1988818350 @default.
• W4327629219 cites W2020627452 @default.
• W4327629219 cites W2055313665 @default.
• W4327629219 cites W2108068107 @default.
• W4327629219 cites W2152883907 @default.
• W4327629219 cites W2168631000 @default.
• W4327629219 cites W2560367415 @default.
• W4327629219 cites W2593030814 @default.
• W4327629219 cites W2625559053 @default.
• W4327629219 cites W2626033245 @default.
• W4327629219 cites W2766273910 @default.
• W4327629219 cites W2795867722 @default.
• W4327629219 cites W2796207838 @default.
• W4327629219 cites W2799997987 @default.
• W4327629219 cites W2889052854 @default.
• W4327629219 cites W2889646458 @default.
• W4327629219 cites W2936931130 @default.
• W4327629219 cites W2937238238 @default.
• W4327629219 cites W2937441321 @default.
• W4327629219 cites W2942669148 @default.
• W4327629219 cites W2943931488 @default.
• W4327629219 cites W2949273159 @default.
• W4327629219 cites W2952391626 @default.
• W4327629219 cites W3002770500 @default.
• W4327629219 cites W3003119869 @default.
• W4327629219 cites W3003319481 @default.
• W4327629219 cites W3005104290 @default.
• W4327629219 cites W3012668557 @default.
• W4327629219 cites W3033396155 @default.
• W4327629219 cites W3038767246 @default.
• W4327629219 cites W3078201066 @default.
• W4327629219 cites W3090177881 @default.
• W4327629219 cites W3092076936 @default.
• W4327629219 cites W3093297428 @default.
• W4327629219 cites W3109885192 @default.
• W4327629219 cites W3121807241 @default.
• W4327629219 cites W3157185054 @default.
• W4327629219 cites W3162952013 @default.
• W4327629219 cites W3165774058 @default.
• W4327629219 cites W3180129935 @default.
• W4327629219 cites W3182293965 @default.
• W4327629219 cites W3193460200 @default.
• W4327629219 cites W3194501923 @default.
• W4327629219 cites W3197752237 @default.
• W4327629219 cites W3202418805 @default.
• W4327629219 cites W3211405363 @default.
• W4327629219 cites W3211668275 @default.
• W4327629219 cites W3213600146 @default.
• W4327629219 cites W4200494868 @default.
• W4327629219 cites W4210774372 @default.
• W4327629219 cites W4220656215 @default.
• W4327629219 cites W4221059041 @default.
• W4327629219 cites W4226106494 @default.
• W4327629219 cites W4280576842 @default.
• W4327629219 cites W4308019622 @default.
• W4327629219 doi "https://doi.org/10.1016/j.tranon.2023.101651" @default.
• W4327629219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36933293" @default.
• W4327629219 hasPublicationYear "2023" @default.
• W4327629219 type Work @default.
• W4327629219 citedByCount "2" @default.
• W4327629219 countsByYear W43276292192023 @default.
• W4327629219 crossrefType "journal-article" @default.
• W4327629219 hasAuthorship W4327629219A5010490479 @default.
• W4327629219 hasAuthorship W4327629219A5017541508 @default.
• W4327629219 hasAuthorship W4327629219A5022948743 @default.
• W4327629219 hasAuthorship W4327629219A5035754451 @default.
• W4327629219 hasAuthorship W4327629219A5043374274 @default.
• W4327629219 hasAuthorship W4327629219A5062180989 @default.
• W4327629219 hasAuthorship W4327629219A5063278481 @default.
• W4327629219 hasAuthorship W4327629219A5076736269 @default.
• W4327629219 hasAuthorship W4327629219A5077232935 @default.
• W4327629219 hasAuthorship W4327629219A5083149235 @default.
• W4327629219 hasBestOaLocation W43276292191 @default.
• W4327629219 hasConcept C104317684 @default.
• W4327629219 hasConcept C143998085 @default.
• W4327629219 hasConcept C145059251 @default.
• W4327629219 hasConcept C150194340 @default.
• W4327629219 hasConcept C162317418 @default.
• W4327629219 hasConcept C203014093 @default.
• W4327629219 hasConcept C20518536 @default.
• W4327629219 hasConcept C2776107976 @default.
• W4327629219 hasConcept C2778019345 @default.

• next