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- W4327634760 abstract "<h3>Background and Design:</h3> Recently, a new category of oncogenes has been discovered that regulate programmed cell death. The<i>bcl</i>-2 oncogene has been found to inhibit cellular death without affecting cellular proliferation. In the skin,<i>bcl</i>-2 expression is limited to cells along the basal cell layer. However, we also noticed that resting melanocytes appeared to express<i>bcl</i>-2. We examined the expression of<i>bcl</i>-2 and its possible role in the biology of benign melanocytic proliferations. Routine paraffin sections of formalin-fixed tissue were labeled with<i>anti</i>-<i>bcl</i>-2 monoclonal antibody, and expression of<i>bcl</i>-2 was detected by a biotin-avidin-immunoperoxidase procedure. <h3>Results:</h3> We examined 13 congenital, 11 acquired, and six atypical or dysplastic nevi for expression of<i>bcl</i>-2. Expression of<i>bcl</i>-2 was observed in 11 of 13 congenital nevi. All 11 acquired nevi and 6 nevi with architectural disarray and cytologic atypia expressed<i>bcl</i>-2. Both junctional and intradermal melanocytes expressed<i>bcl</i>-2 in a perinuclear and cytoplasmic pattern. Within neurotized areas,<i>bcl</i>-2 became significantly weaker and totally absent. <h3>Conclusions:</h3> In mature tissues,<i>bcl</i>-2 expression is quite limited. It appears to be restricted to pluripotential stem cells that serve as a reservoir for tissue that is constantly undergoing renewal, such as the hematopoietic cells and the intestinal mucosa. In the skin,<i>bcl</i>-2 expression has been previously reported to be limited to the epidermal basal cell layer and proliferation zones. Our results indicate that resting melanocytes and melanocytic nevi regularly express<sup>bcl</sup>-2. (Arch Dermatol. 1995;131:915-918)" @default.
- W4327634760 created "2023-03-18" @default.
- W4327634760 creator A5005966997 @default.
- W4327634760 date "1995-08-01" @default.
- W4327634760 modified "2023-09-23" @default.
- W4327634760 title "bcl-2 Expression in Melanocytic Nevi" @default.
- W4327634760 doi "https://doi.org/10.1001/archderm.1995.01690200051010" @default.
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