FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327640212> ?p ?o ?g. }

• W4327640212 endingPage "163" @default.
• W4327640212 startingPage "149" @default.
• W4327640212 abstract "Non-alcoholic fatty liver disease (NAFLD) is closely associated with low-grade chronic inflammation which is usually induced by intestinal dysbiosis. As ferulic acid (FA) has been proven effective at improving the intestinal integrity, we aimed to determine the effect of dietary FA on NAFLD development in high-fat dieted (HFD) mice, a well-established model of NAFLD. Male C57BL/6J mice were fed either a normal chow diet (ND) or HFD with or without FA (40 mg/kg) orally for 6 weeks. FA significantly alleviated lipid metabolism disorder and reduced liver inflammation in HFD mice (P < 0.05). As expected, FA improved the ileal intestinal integrity likely via the Nuclear factor E2-related factor 2 (Nrf2)/Heme oxygenase-1 (HO-1) signaling pathway. Importantly, we found that FA also relieved HFD-induced gut microbiota dysbiosis by inhibiting the growth of harmful bacteria such as Helicobacter and increased the abundance of many short-chain fatty acids (SCFAs)-producing bacteria (P < 0.05). Our data indicated that FA not only increased the colonic levels of SCFAs, but also maintained the colonic barrier integrity by up-regulating the expression of the epithelial tight junction protein. These data indicated that FA alleviated NAFLD by reducing circulating lipopolysaccharide levels. These effects may be due to improved proximal and distal intestinal barriers, which presumably mediated through the interaction of FA with the gut microbiota." @default.
• W4327640212 created "2023-03-18" @default.
• W4327640212 creator A5011804718 @default.
• W4327640212 creator A5013422352 @default.
• W4327640212 creator A5015861344 @default.
• W4327640212 creator A5032351338 @default.
• W4327640212 creator A5035149095 @default.
• W4327640212 creator A5041744833 @default.
• W4327640212 creator A5071664517 @default.
• W4327640212 creator A5086274856 @default.
• W4327640212 date "2023-01-01" @default.
• W4327640212 modified "2023-09-26" @default.
• W4327640212 title "Ferulic Acid Alleviates Hepatic Lipid Accumulation and Inflammation by Improving Proximal and Distal Intestinal Barriers in NAFLD Mice" @default.
• W4327640212 cites W2007434989 @default.
• W4327640212 cites W2038100201 @default.
• W4327640212 cites W2084868870 @default.
• W4327640212 cites W2086770167 @default.
• W4327640212 cites W2139334262 @default.
• W4327640212 cites W2286631594 @default.
• W4327640212 cites W2324161694 @default.
• W4327640212 cites W2754184494 @default.
• W4327640212 cites W2758047358 @default.
• W4327640212 cites W2799290037 @default.
• W4327640212 cites W2883373675 @default.
• W4327640212 cites W2899585331 @default.
• W4327640212 cites W2920929185 @default.
• W4327640212 cites W2965140029 @default.
• W4327640212 cites W2980059162 @default.
• W4327640212 cites W2999161272 @default.
• W4327640212 cites W3012014464 @default.
• W4327640212 cites W3014498810 @default.
• W4327640212 cites W3092750669 @default.
• W4327640212 cites W3108056234 @default.
• W4327640212 cites W3120205687 @default.
• W4327640212 cites W3120740884 @default.
• W4327640212 cites W3131885513 @default.
• W4327640212 cites W3164972712 @default.
• W4327640212 cites W3170162444 @default.
• W4327640212 cites W3184325305 @default.
• W4327640212 cites W3197253372 @default.
• W4327640212 cites W3199789486 @default.
• W4327640212 cites W3208249635 @default.
• W4327640212 cites W3210803765 @default.
• W4327640212 cites W3211739109 @default.
• W4327640212 cites W3216046892 @default.
• W4327640212 cites W4200440801 @default.
• W4327640212 cites W4224214163 @default.
• W4327640212 cites W4283119287 @default.
• W4327640212 cites W4283204635 @default.
• W4327640212 cites W4283263269 @default.
• W4327640212 cites W4283659798 @default.
• W4327640212 cites W4285084890 @default.
• W4327640212 cites W4288039437 @default.
• W4327640212 doi "https://doi.org/10.1620/tjem.2023.j023" @default.
• W4327640212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36927682" @default.
• W4327640212 hasPublicationYear "2023" @default.
• W4327640212 type Work @default.
• W4327640212 citedByCount "0" @default.
• W4327640212 crossrefType "journal-article" @default.
• W4327640212 hasAuthorship W4327640212A5011804718 @default.
• W4327640212 hasAuthorship W4327640212A5013422352 @default.
• W4327640212 hasAuthorship W4327640212A5015861344 @default.
• W4327640212 hasAuthorship W4327640212A5032351338 @default.
• W4327640212 hasAuthorship W4327640212A5035149095 @default.
• W4327640212 hasAuthorship W4327640212A5041744833 @default.
• W4327640212 hasAuthorship W4327640212A5071664517 @default.
• W4327640212 hasAuthorship W4327640212A5086274856 @default.
• W4327640212 hasBestOaLocation W43276402121 @default.
• W4327640212 hasConcept C126322002 @default.
• W4327640212 hasConcept C134018914 @default.
• W4327640212 hasConcept C185592680 @default.
• W4327640212 hasConcept C2776914184 @default.
• W4327640212 hasConcept C2777165150 @default.
• W4327640212 hasConcept C2778754761 @default.
• W4327640212 hasConcept C2778772119 @default.
• W4327640212 hasConcept C2779134260 @default.
• W4327640212 hasConcept C2780213334 @default.
• W4327640212 hasConcept C4733338 @default.
• W4327640212 hasConcept C539455810 @default.
• W4327640212 hasConcept C55493867 @default.
• W4327640212 hasConcept C71924100 @default.
• W4327640212 hasConceptScore W4327640212C126322002 @default.
• W4327640212 hasConceptScore W4327640212C134018914 @default.
• W4327640212 hasConceptScore W4327640212C185592680 @default.
• W4327640212 hasConceptScore W4327640212C2776914184 @default.
• W4327640212 hasConceptScore W4327640212C2777165150 @default.
• W4327640212 hasConceptScore W4327640212C2778754761 @default.
• W4327640212 hasConceptScore W4327640212C2778772119 @default.
• W4327640212 hasConceptScore W4327640212C2779134260 @default.
• W4327640212 hasConceptScore W4327640212C2780213334 @default.
• W4327640212 hasConceptScore W4327640212C4733338 @default.
• W4327640212 hasConceptScore W4327640212C539455810 @default.
• W4327640212 hasConceptScore W4327640212C55493867 @default.
• W4327640212 hasConceptScore W4327640212C71924100 @default.
• W4327640212 hasIssue "2" @default.
• W4327640212 hasLocation W43276402121 @default.
• W4327640212 hasLocation W43276402122 @default.
• W4327640212 hasOpenAccess W4327640212 @default.

• next