Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327676764> ?p ?o ?g. }
- W4327676764 abstract "SARS-CoV-2 emergent variants are characterized by increased viral fitness and each shows multiple mutations predominantly localized to the spike (S) protein. Here, amide hydrogen/deuterium exchange mass spectrometry has been applied to track changes in S dynamics from multiple SARS-CoV-2 variants. Our results highlight large differences across variants at two loci with impacts on S dynamics and stability. A significant enhancement in stabilization first occurred with the emergence of D614G S followed by smaller, progressive stabilization in subsequent variants. Stabilization preceded altered dynamics in the N-terminal domain, wherein Omicron BA.1 S showed the largest magnitude increases relative to other preceding variants. Changes in stabilization and dynamics resulting from S mutations detail the evolutionary trajectory of S in emerging variants. These carry major implications for SARS-CoV-2 viral fitness and offer new insights into variant-specific therapeutic development." @default.
- W4327676764 created "2023-03-18" @default.
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- W4327676764 date "2023-03-17" @default.
- W4327676764 modified "2023-10-18" @default.
- W4327676764 title "Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics" @default.
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- W4327676764 doi "https://doi.org/10.7554/elife.82584" @default.
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