FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327678712> ?p ?o ?g. }

• W4327678712 endingPage "e0275351" @default.
• W4327678712 startingPage "e0275351" @default.
• W4327678712 abstract "The majority of fast, excitatory synaptic transmission in the central nervous system (CNS) is mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), which are glutamate-activated ion channels integral to synaptic plasticity, motor coordination, learning, and memory. Native AMPARs are multiprotein assemblies comprised of a tetrameric receptor core that co-assembles with a broad range of peripheral auxiliary proteins which shape subcellular localization and signaling properties of the resulting complexes. Structure determination of AMPARs has traditionally relied on recombinant expression systems; however, these methods are not well suited to elucidate the diverse array of AMPAR assemblies that are differentially expressed in mammalian brains. While recent studies of native receptor complexes have advanced our understanding of endogenous assemblies, receptors thus far have only been isolated from rodent brain tissue. Here, we employed an immunoaffinity purification strategy to isolate native AMPARs from the brains of three different mammals-pigs, sheep, and cows. Compared to rodents, pigs, sheep, and cows are ungulate mammals, animals with closer genomic identity with humans. Here we determined the molecular size, overall yield, and purity of native AMPARs isolated from these three mammals, thereby demonstrating that structural determination and biochemical analysis is possible from a clade of mammals evolutionarily distinct from rodents." @default.
• W4327678712 created "2023-03-18" @default.
• W4327678712 creator A5069672297 @default.
• W4327678712 creator A5088125571 @default.
• W4327678712 date "2023-03-17" @default.
• W4327678712 modified "2023-09-25" @default.
• W4327678712 title "Purification and biochemical analysis of native AMPA receptors from three different mammalian species" @default.
• W4327678712 cites W1516646376 @default.
• W4327678712 cites W1931402103 @default.
• W4327678712 cites W1972391943 @default.
• W4327678712 cites W1985326228 @default.
• W4327678712 cites W1986923087 @default.
• W4327678712 cites W1994699932 @default.
• W4327678712 cites W2000300989 @default.
• W4327678712 cites W2003954715 @default.
• W4327678712 cites W2004277471 @default.
• W4327678712 cites W2007270668 @default.
• W4327678712 cites W2007460859 @default.
• W4327678712 cites W2018358410 @default.
• W4327678712 cites W2022089839 @default.
• W4327678712 cites W2026152781 @default.
• W4327678712 cites W2028185267 @default.
• W4327678712 cites W2037852973 @default.
• W4327678712 cites W2045541816 @default.
• W4327678712 cites W2047835829 @default.
• W4327678712 cites W2053739294 @default.
• W4327678712 cites W2061108756 @default.
• W4327678712 cites W2063461600 @default.
• W4327678712 cites W2065510140 @default.
• W4327678712 cites W2067915400 @default.
• W4327678712 cites W2071950147 @default.
• W4327678712 cites W2076813919 @default.
• W4327678712 cites W2076838768 @default.
• W4327678712 cites W2085507259 @default.
• W4327678712 cites W2085525762 @default.
• W4327678712 cites W2086881332 @default.
• W4327678712 cites W2090872672 @default.
• W4327678712 cites W2124427860 @default.
• W4327678712 cites W2125426676 @default.
• W4327678712 cites W2153928331 @default.
• W4327678712 cites W2162520530 @default.
• W4327678712 cites W2162746575 @default.
• W4327678712 cites W2467790803 @default.
• W4327678712 cites W2611393411 @default.
• W4327678712 cites W2731059737 @default.
• W4327678712 cites W2735674872 @default.
• W4327678712 cites W2738417757 @default.
• W4327678712 cites W2766528848 @default.
• W4327678712 cites W2803965980 @default.
• W4327678712 cites W2888208011 @default.
• W4327678712 cites W2897538931 @default.
• W4327678712 cites W2898344414 @default.
• W4327678712 cites W2921210647 @default.
• W4327678712 cites W2928571921 @default.
• W4327678712 cites W2936622381 @default.
• W4327678712 cites W2952442706 @default.
• W4327678712 cites W2952947028 @default.
• W4327678712 cites W2979485701 @default.
• W4327678712 cites W2991747527 @default.
• W4327678712 cites W3149030049 @default.
• W4327678712 cites W3163624776 @default.
• W4327678712 cites W3179784151 @default.
• W4327678712 cites W3199831722 @default.
• W4327678712 cites W4224224540 @default.
• W4327678712 cites W4225495036 @default.
• W4327678712 cites W4304698157 @default.
• W4327678712 doi "https://doi.org/10.1371/journal.pone.0275351" @default.
• W4327678712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36930594" @default.
• W4327678712 hasPublicationYear "2023" @default.
• W4327678712 type Work @default.
• W4327678712 citedByCount "0" @default.
• W4327678712 crossrefType "journal-article" @default.
• W4327678712 hasAuthorship W4327678712A5069672297 @default.
• W4327678712 hasAuthorship W4327678712A5088125571 @default.
• W4327678712 hasBestOaLocation W43276787121 @default.
• W4327678712 hasConcept C160268369 @default.
• W4327678712 hasConcept C169760540 @default.
• W4327678712 hasConcept C170493617 @default.
• W4327678712 hasConcept C200170125 @default.
• W4327678712 hasConcept C55493867 @default.
• W4327678712 hasConcept C61174792 @default.
• W4327678712 hasConcept C86803240 @default.
• W4327678712 hasConcept C95444343 @default.
• W4327678712 hasConcept C98229152 @default.
• W4327678712 hasConceptScore W4327678712C160268369 @default.
• W4327678712 hasConceptScore W4327678712C169760540 @default.
• W4327678712 hasConceptScore W4327678712C170493617 @default.
• W4327678712 hasConceptScore W4327678712C200170125 @default.
• W4327678712 hasConceptScore W4327678712C55493867 @default.
• W4327678712 hasConceptScore W4327678712C61174792 @default.
• W4327678712 hasConceptScore W4327678712C86803240 @default.
• W4327678712 hasConceptScore W4327678712C95444343 @default.
• W4327678712 hasConceptScore W4327678712C98229152 @default.
• W4327678712 hasFunder F4320306082 @default.
• W4327678712 hasFunder F4320337359 @default.
• W4327678712 hasIssue "3" @default.
• W4327678712 hasLocation W43276787121 @default.
• W4327678712 hasLocation W43276787122 @default.

• next