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• W4327682014 abstract "Objective: To evaluate the impact of individual and combined assessment of age- and sex-specific brachial-ankle pulse wave velocity (baPWV) and pulse pressure (PP) on all-cause mortality. Methods: This study is a prospective cohort study. Individuals participated in the Kailuan Study and completed baPWV measurements between 2010 and 2016 were included in this study. After stratifying by sex, 75th percentile baPWV and PP values for different age group were calculated at five years interval. BaPWV and PP values below the 75th percentile were defined as normal, and those above or equal to the 75th percentile were defined as increased. The participants were allocated to four groups according to their PP and baPWV status: normal baPWV/PP group, high baPWV/normal PP group, normal baPWV/high PP group and high baPWV/PP group. The primary outcome was all-cause mortality during the follow-up period. Cox proportional hazards models were used to explore the impact of individual and combined assessment of baPWV and PP on all-cause mortality events. Results: A total of 39 339 participants were enrolled in this study, aged (49.3±12.8) years, of which 28 731 (73.03%) were males. There were 23 268, 6 025, 6 210 and 3 836 cases in the normal baPWV/PP group, high baPWV/normal PP group, normal baPWV/high PP group and high baPWV/PP group, respectively. The average follow-up duration was (4.98±2.53) years. During the follow-up period, all-cause mortality occurred in 998 individuals. Multivariate Cox regression analysis showed increased risk of all-cause mortality in the high baPWV/normal PP group (HR=1.27, 95%CI 1.07-1.50), and in the high baPWV/PP group (HR=1.33, 95%CI 1.08-1.65) compared to the normal baPWV/PP group. Increased pulse pressure alone had no impcat on all-cause death (HR=1.06, 95%CI 0.87-1.29). Conclusions: The risk of all-cause mortality significantly increases with increased age-and sex-specific baPWV and PP values. BaPWV may be a better predictor of all-cause mortality than PP in this cohort.目的： 探讨与性别、年龄相关的臂踝脉搏波传导速度（baPWV）与脉压对全因死亡的单独及联合作用。 方法： 本研究为前瞻性队列研究，选取开滦研究中参加2010至2016年度健康体检、完成baPWV测量且后续进行了随访的人群作为研究对象。按照不同性别分层后，以每5岁为一组计算不同年龄组的baPWV和脉压的75%分位数，将<75%分位数定义为正常，将≥75%分位数定义为增高，根据baPWV和脉压水平，将研究对象分为4组：baPWV和脉压均正常组、baPWV增高和脉压正常组、baPWV正常和脉压增高组、baPWV和脉压均增高组。主要结局为全因死亡。采用Cox风险比例模型探讨baPWV和脉压对全因死亡的单独及联合作用。 结果： 共纳入39 339人，年龄（49.3±12.8）岁，其中男性28 731人（73.03%）。baPWV和脉压均正常组、baPWV增高和脉压正常组、baPWV正常和脉压增高组、baPWV和脉压均增高组分别有23 268、6 025、6 210和3 836人。随访（4.98±2.53）年，共发生全因死亡998例。多因素Cox回归分析结果显示，与baPWV和脉压均正常组相比，baPWV增高和脉压正常组（HR=1.27，95%CI 1.07~1.50）、baPWV和脉压均增高组（HR=1.33，95%CI 1.08~1.65）发生全因死亡的风险增加；而单独脉压增高对全因死亡无影响（HR=1.06，95%CI 0.87~1.29）。 结论： 与性别、年龄相关的baPWV与脉压均升高时全因死亡的发生风险明显增加，与脉压相比，baPWV可能是发生全因死亡更重要的预测因子。." @default.
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• W4327682014 date "2023-03-24" @default.
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• W4327682014 title "[Impact of individual and combined assessment of age- and sex-specific brachial-ankle pulse wave velocity and pulse pressure on all-cause mortality]." @default.
• W4327682014 doi "https://doi.org/10.3760/cma.j.cn112148-20230117-00033" @default.
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