FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327699146> ?p ?o ?g. }

• W4327699146 abstract "Abstract Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve the prediction of complex traits and diseases. However, most existing PRS are primarily trained on European ancestry populations, limiting their transferability to non-European populations. In this article, we propose a novel method for generating multi-ancestry Polygenic Risk scOres based on enSemble of PEnalized Regression models (PROSPER). PROSPER integrates genome-wide association studies (GWAS) summary statistics from diverse populations to develop ancestry-specific PRS with improved predictive power for minority populations. The method uses a combination of ℒ 1 (lasso) and ℒ 2 (ridge) penalty functions, a parsimonious specification of the penalty parameters across populations, and an ensemble step to combine PRS generated across different penalty parameters. We evaluate the performance of PROSPER and other existing methods on large-scale simulated and real datasets, including those from 23andMe Inc., the Global Lipids Genetics Consortium, and All of Us. Results show that PROSPER can substantially improve multi-ancestry polygenic prediction compared to alternative methods across a wide variety of genetic architectures. In real data analyses, for example, PROSPER increased out-of-sample prediction R 2 for continuous traits by an average of 70% compared to a state-of-the-art Bayesian method (PRS-CSx) in the African ancestry population. Further, PROSPER is computationally highly scalable for the analysis of large SNP contents and many diverse populations." @default.
• W4327699146 created "2023-03-18" @default.
• W4327699146 creator A5015067632 @default.
• W4327699146 creator A5016359358 @default.
• W4327699146 creator A5020388068 @default.
• W4327699146 creator A5025017847 @default.
• W4327699146 creator A5030078384 @default.
• W4327699146 creator A5041659230 @default.
• W4327699146 creator A5044249548 @default.
• W4327699146 creator A5050900882 @default.
• W4327699146 creator A5051936798 @default.
• W4327699146 creator A5087290588 @default.
• W4327699146 date "2023-03-16" @default.
• W4327699146 modified "2023-10-06" @default.
• W4327699146 title "An Ensemble Penalized Regression Method for Multi-ancestry Polygenic Risk Prediction" @default.
• W4327699146 cites W1997338841 @default.
• W4327699146 cites W2005935256 @default.
• W4327699146 cites W2020925091 @default.
• W4327699146 cites W2069435832 @default.
• W4327699146 cites W2097656361 @default.
• W4327699146 cites W2104549677 @default.
• W4327699146 cites W2107916366 @default.
• W4327699146 cites W2135046866 @default.
• W4327699146 cites W2140514146 @default.
• W4327699146 cites W2161633633 @default.
• W4327699146 cites W2169795969 @default.
• W4327699146 cites W2438256301 @default.
• W4327699146 cites W2531587846 @default.
• W4327699146 cites W2563392956 @default.
• W4327699146 cites W2613151407 @default.
• W4327699146 cites W2725988230 @default.
• W4327699146 cites W2901303766 @default.
• W4327699146 cites W2901952863 @default.
• W4327699146 cites W2922534626 @default.
• W4327699146 cites W2924348116 @default.
• W4327699146 cites W2927029344 @default.
• W4327699146 cites W2932671560 @default.
• W4327699146 cites W2950135831 @default.
• W4327699146 cites W2952013316 @default.
• W4327699146 cites W2970480306 @default.
• W4327699146 cites W2978243962 @default.
• W4327699146 cites W2980086570 @default.
• W4327699146 cites W2991034145 @default.
• W4327699146 cites W3014994762 @default.
• W4327699146 cites W3017979401 @default.
• W4327699146 cites W3022199624 @default.
• W4327699146 cites W3089846215 @default.
• W4327699146 cites W3110169235 @default.
• W4327699146 cites W3136190300 @default.
• W4327699146 cites W3181344512 @default.
• W4327699146 cites W3205644245 @default.
• W4327699146 cites W4205170775 @default.
• W4327699146 cites W4211005061 @default.
• W4327699146 cites W4220778359 @default.
• W4327699146 cites W4221055706 @default.
• W4327699146 cites W4229035861 @default.
• W4327699146 cites W4233056867 @default.
• W4327699146 cites W4233345704 @default.
• W4327699146 cites W4248240383 @default.
• W4327699146 cites W4255455317 @default.
• W4327699146 cites W4280552086 @default.
• W4327699146 cites W4292241266 @default.
• W4327699146 cites W4298138773 @default.
• W4327699146 cites W4298144476 @default.
• W4327699146 cites W4303650478 @default.
• W4327699146 cites W4304695003 @default.
• W4327699146 cites W4386136485 @default.
• W4327699146 doi "https://doi.org/10.1101/2023.03.15.532652" @default.
• W4327699146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36993331" @default.
• W4327699146 hasPublicationYear "2023" @default.
• W4327699146 type Work @default.
• W4327699146 citedByCount "3" @default.
• W4327699146 countsByYear W43276991462023 @default.
• W4327699146 crossrefType "posted-content" @default.
• W4327699146 hasAuthorship W4327699146A5015067632 @default.
• W4327699146 hasAuthorship W4327699146A5016359358 @default.
• W4327699146 hasAuthorship W4327699146A5020388068 @default.
• W4327699146 hasAuthorship W4327699146A5025017847 @default.
• W4327699146 hasAuthorship W4327699146A5030078384 @default.
• W4327699146 hasAuthorship W4327699146A5041659230 @default.
• W4327699146 hasAuthorship W4327699146A5044249548 @default.
• W4327699146 hasAuthorship W4327699146A5050900882 @default.
• W4327699146 hasAuthorship W4327699146A5051936798 @default.
• W4327699146 hasAuthorship W4327699146A5087290588 @default.
• W4327699146 hasBestOaLocation W43276991461 @default.
• W4327699146 hasConcept C104317684 @default.
• W4327699146 hasConcept C105795698 @default.
• W4327699146 hasConcept C106208931 @default.
• W4327699146 hasConcept C107673813 @default.
• W4327699146 hasConcept C119857082 @default.
• W4327699146 hasConcept C135763542 @default.
• W4327699146 hasConcept C136764020 @default.
• W4327699146 hasConcept C144024400 @default.
• W4327699146 hasConcept C149782125 @default.
• W4327699146 hasConcept C149923435 @default.
• W4327699146 hasConcept C153209595 @default.
• W4327699146 hasConcept C154945302 @default.
• W4327699146 hasConcept C186413461 @default.
• W4327699146 hasConcept C203868755 @default.
• W4327699146 hasConcept C2908647359 @default.

• next