Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327714810> ?p ?o ?g. }
- W4327714810 abstract "Punctuated bursts of structural genomic variations (SVs) have been described in various organisms, but their etiology remains incompletely understood. Homologous recombination (HR) is a template-guided mechanism of repair of DNA double-strand breaks and stalled or collapsed replication forks. We recently identified a DNA break amplification and genome rearrangement pathway originating from the endonucleolytic processing of a multi-invasion (MI) DNA joint molecule formed during HR. Genome-wide sequencing approaches confirmed that multi-invasion-induced rearrangement (MIR) frequently leads to several repeat-mediated SVs and aneuploidies. Using molecular and genetic analysis, and a novel, highly sensitive proximity ligation-based assay for chromosomal rearrangement quantification, we further delineate two MIR sub-pathways. MIR1 is a universal pathway occurring in any sequence context, which generates secondary breaks and frequently leads to additional SVs. MIR2 occurs only if recombining donors exhibit substantial homology, and results in sequence insertion without additional break or SV. The most detrimental MIR1 pathway occurs late on a subset of persisting DNA joint molecules in a PCNA/Polδ-independent manner, unlike recombinational DNA synthesis. This work provides a refined mechanistic understanding of these HR-based SV formation pathways and shows that complex repeat-mediated SVs can occur without displacement DNA synthesis. Sequence signatures for inferring MIR1 from long-read data are proposed." @default.
- W4327714810 created "2023-03-18" @default.
- W4327714810 creator A5027473293 @default.
- W4327714810 creator A5032738100 @default.
- W4327714810 creator A5042624000 @default.
- W4327714810 creator A5051968023 @default.
- W4327714810 creator A5063707937 @default.
- W4327714810 creator A5069668672 @default.
- W4327714810 creator A5077144188 @default.
- W4327714810 date "2023-03-16" @default.
- W4327714810 modified "2023-10-18" @default.
- W4327714810 title "Delineation of two multi-invasion-induced rearrangement pathways that differently affect genome stability" @default.
- W4327714810 cites W1568677771 @default.
- W4327714810 cites W1900907818 @default.
- W4327714810 cites W1964831588 @default.
- W4327714810 cites W1964993093 @default.
- W4327714810 cites W1967491579 @default.
- W4327714810 cites W1976044679 @default.
- W4327714810 cites W1978005916 @default.
- W4327714810 cites W1981946886 @default.
- W4327714810 cites W1983841355 @default.
- W4327714810 cites W1992132685 @default.
- W4327714810 cites W1993026474 @default.
- W4327714810 cites W1995831273 @default.
- W4327714810 cites W2016357039 @default.
- W4327714810 cites W2021955395 @default.
- W4327714810 cites W2024172421 @default.
- W4327714810 cites W2028504500 @default.
- W4327714810 cites W2030899259 @default.
- W4327714810 cites W2032750781 @default.
- W4327714810 cites W2034252391 @default.
- W4327714810 cites W2038462200 @default.
- W4327714810 cites W2046832453 @default.
- W4327714810 cites W2048729396 @default.
- W4327714810 cites W2050164609 @default.
- W4327714810 cites W2051571475 @default.
- W4327714810 cites W2076459721 @default.
- W4327714810 cites W2077570881 @default.
- W4327714810 cites W2086717522 @default.
- W4327714810 cites W2092850111 @default.
- W4327714810 cites W2094020226 @default.
- W4327714810 cites W2113908436 @default.
- W4327714810 cites W2115369480 @default.
- W4327714810 cites W2120256120 @default.
- W4327714810 cites W2136223090 @default.
- W4327714810 cites W2136232605 @default.
- W4327714810 cites W2143405836 @default.
- W4327714810 cites W2144839130 @default.
- W4327714810 cites W2148573025 @default.
- W4327714810 cites W2151198423 @default.
- W4327714810 cites W2156466607 @default.
- W4327714810 cites W2344857673 @default.
- W4327714810 cites W2531887049 @default.
- W4327714810 cites W2570792050 @default.
- W4327714810 cites W2617801553 @default.
- W4327714810 cites W2730149205 @default.
- W4327714810 cites W2743369001 @default.
- W4327714810 cites W2774408266 @default.
- W4327714810 cites W2793424148 @default.
- W4327714810 cites W2794099162 @default.
- W4327714810 cites W2944852748 @default.
- W4327714810 cites W2949062400 @default.
- W4327714810 cites W2951445876 @default.
- W4327714810 cites W2969343221 @default.
- W4327714810 cites W2970567683 @default.
- W4327714810 cites W3006500278 @default.
- W4327714810 cites W3022980205 @default.
- W4327714810 cites W3033870872 @default.
- W4327714810 cites W3047588650 @default.
- W4327714810 cites W3057437418 @default.
- W4327714810 cites W3080331291 @default.
- W4327714810 cites W3094607971 @default.
- W4327714810 cites W3131452536 @default.
- W4327714810 cites W3184372780 @default.
- W4327714810 cites W3214593009 @default.
- W4327714810 cites W4205962915 @default.
- W4327714810 cites W4281983143 @default.
- W4327714810 cites W4287448803 @default.
- W4327714810 cites W4295882819 @default.
- W4327714810 cites W4309665152 @default.
- W4327714810 cites W4318150360 @default.
- W4327714810 cites W4327806227 @default.
- W4327714810 doi "https://doi.org/10.1101/2023.03.15.532751" @default.
- W4327714810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36993162" @default.
- W4327714810 hasPublicationYear "2023" @default.
- W4327714810 type Work @default.
- W4327714810 citedByCount "1" @default.
- W4327714810 countsByYear W43277148102023 @default.
- W4327714810 crossrefType "posted-content" @default.
- W4327714810 hasAuthorship W4327714810A5027473293 @default.
- W4327714810 hasAuthorship W4327714810A5032738100 @default.
- W4327714810 hasAuthorship W4327714810A5042624000 @default.
- W4327714810 hasAuthorship W4327714810A5051968023 @default.
- W4327714810 hasAuthorship W4327714810A5063707937 @default.
- W4327714810 hasAuthorship W4327714810A5069668672 @default.
- W4327714810 hasAuthorship W4327714810A5077144188 @default.
- W4327714810 hasBestOaLocation W43277148101 @default.
- W4327714810 hasConcept C102744134 @default.
- W4327714810 hasConcept C104317684 @default.
- W4327714810 hasConcept C141231307 @default.