FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327716795> ?p ?o ?g. }

• W4327716795 abstract "<p> </p> <p><strong>Objective</strong></p> <p>Previous studies showed that inhibiting lymphocyte costimulation reduces declining beta cell function in individuals newly-diagnosed with type 1 diabetes. We tested whether abatacept would delay or prevent progression of type 1 diabetes from normal (NGT) to abnormal (AGT) glucose tolerance or to diabetes and the effects of treatment on immune and metabolic responses. </p> <p><strong>Research Design and Methods</strong></p> <p>We conducted a phase-2, randomized, placebo-controlled, double-masked trial of abatacept</p> <p>in antibody-positive participants with NGT who received monthly abatacept/placebo infusions for 12 months. The endpoint was AGT or diabetes, assessed by oral glucose-tolerance tests. </p> <p><strong>Results</strong></p> <p>101 participants received abatacept and 111 placebo. Eighty-one (35 abatacept/46 placebo) met the endpoint of AGT or type 1 diabetes diagnosis (HR=0.702 (0.452, 1.09)(p=0.11) The C-peptide responses to OGTTs were higher in the abatacept arm (p<.03) . Abatacept reduced the frequency of ICOS+PD1+ T-follicular helper (Tfh) cells during treatment (p<0.0001), increased naïve CD4+ T cells, and also reduced the frequency of CD4+ Tregs from the baseline (p=0.0067). Twelve months after treatment, the frequency of ICOS+ Tfh, naïve CD4+ T, and Treg cells returned to baseline. </p> <p><strong>Conclusions</strong></p> <p>Although abatacept treatment for one year did not significantly delay progression to glucose intolerance in at-risk individuals, it impacted immune cell subsets and preserved insulin secretion suggesting that costimulation blockade may modify progression of type 1 diabetes.</p>" @default.
• W4327716795 created "2023-03-18" @default.
• W4327716795 creator A5004600163 @default.
• W4327716795 creator A5010737034 @default.
• W4327716795 creator A5010764462 @default.
• W4327716795 creator A5013624991 @default.
• W4327716795 creator A5019463621 @default.
• W4327716795 creator A5020555978 @default.
• W4327716795 creator A5023214700 @default.
• W4327716795 creator A5025956771 @default.
• W4327716795 creator A5026077691 @default.
• W4327716795 creator A5031541043 @default.
• W4327716795 creator A5038772102 @default.
• W4327716795 creator A5043324727 @default.
• W4327716795 creator A5049161204 @default.
• W4327716795 creator A5050754705 @default.
• W4327716795 creator A5052802925 @default.
• W4327716795 creator A5060877437 @default.
• W4327716795 creator A5062610230 @default.
• W4327716795 creator A5068398869 @default.
• W4327716795 creator A5073135259 @default.
• W4327716795 creator A5074319617 @default.
• W4327716795 creator A5076061181 @default.
• W4327716795 creator A5083458282 @default.
• W4327716795 creator A5083462423 @default.
• W4327716795 creator A5084625995 @default.
• W4327716795 creator A5091635904 @default.
• W4327716795 date "2023-03-15" @default.
• W4327716795 modified "2023-10-06" @default.
• W4327716795 title "Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial" @default.
• W4327716795 doi "https://doi.org/10.2337/figshare.22009586.v1" @default.
• W4327716795 hasPublicationYear "2023" @default.
• W4327716795 type Work @default.
• W4327716795 citedByCount "0" @default.
• W4327716795 crossrefType "posted-content" @default.
• W4327716795 hasAuthorship W4327716795A5004600163 @default.
• W4327716795 hasAuthorship W4327716795A5010737034 @default.
• W4327716795 hasAuthorship W4327716795A5010764462 @default.
• W4327716795 hasAuthorship W4327716795A5013624991 @default.
• W4327716795 hasAuthorship W4327716795A5019463621 @default.
• W4327716795 hasAuthorship W4327716795A5020555978 @default.
• W4327716795 hasAuthorship W4327716795A5023214700 @default.
• W4327716795 hasAuthorship W4327716795A5025956771 @default.
• W4327716795 hasAuthorship W4327716795A5026077691 @default.
• W4327716795 hasAuthorship W4327716795A5031541043 @default.
• W4327716795 hasAuthorship W4327716795A5038772102 @default.
• W4327716795 hasAuthorship W4327716795A5043324727 @default.
• W4327716795 hasAuthorship W4327716795A5049161204 @default.
• W4327716795 hasAuthorship W4327716795A5050754705 @default.
• W4327716795 hasAuthorship W4327716795A5052802925 @default.
• W4327716795 hasAuthorship W4327716795A5060877437 @default.
• W4327716795 hasAuthorship W4327716795A5062610230 @default.
• W4327716795 hasAuthorship W4327716795A5068398869 @default.
• W4327716795 hasAuthorship W4327716795A5073135259 @default.
• W4327716795 hasAuthorship W4327716795A5074319617 @default.
• W4327716795 hasAuthorship W4327716795A5076061181 @default.
• W4327716795 hasAuthorship W4327716795A5083458282 @default.
• W4327716795 hasAuthorship W4327716795A5083462423 @default.
• W4327716795 hasAuthorship W4327716795A5084625995 @default.
• W4327716795 hasAuthorship W4327716795A5091635904 @default.
• W4327716795 hasBestOaLocation W43277167951 @default.
• W4327716795 hasConcept C126322002 @default.
• W4327716795 hasConcept C134018914 @default.
• W4327716795 hasConcept C142724271 @default.
• W4327716795 hasConcept C168563851 @default.
• W4327716795 hasConcept C203092338 @default.
• W4327716795 hasConcept C204787440 @default.
• W4327716795 hasConcept C27081682 @default.
• W4327716795 hasConcept C2777180221 @default.
• W4327716795 hasConcept C2779338263 @default.
• W4327716795 hasConcept C2779605438 @default.
• W4327716795 hasConcept C2780653079 @default.
• W4327716795 hasConcept C2781232474 @default.
• W4327716795 hasConcept C555293320 @default.
• W4327716795 hasConcept C71924100 @default.
• W4327716795 hasConcept C90924648 @default.
• W4327716795 hasConceptScore W4327716795C126322002 @default.
• W4327716795 hasConceptScore W4327716795C134018914 @default.
• W4327716795 hasConceptScore W4327716795C142724271 @default.
• W4327716795 hasConceptScore W4327716795C168563851 @default.
• W4327716795 hasConceptScore W4327716795C203092338 @default.
• W4327716795 hasConceptScore W4327716795C204787440 @default.
• W4327716795 hasConceptScore W4327716795C27081682 @default.
• W4327716795 hasConceptScore W4327716795C2777180221 @default.
• W4327716795 hasConceptScore W4327716795C2779338263 @default.
• W4327716795 hasConceptScore W4327716795C2779605438 @default.
• W4327716795 hasConceptScore W4327716795C2780653079 @default.
• W4327716795 hasConceptScore W4327716795C2781232474 @default.
• W4327716795 hasConceptScore W4327716795C555293320 @default.
• W4327716795 hasConceptScore W4327716795C71924100 @default.
• W4327716795 hasConceptScore W4327716795C90924648 @default.
• W4327716795 hasLocation W43277167951 @default.
• W4327716795 hasOpenAccess W4327716795 @default.
• W4327716795 hasPrimaryLocation W43277167951 @default.
• W4327716795 hasRelatedWork W2064458105 @default.
• W4327716795 hasRelatedWork W2096629763 @default.
• W4327716795 hasRelatedWork W2127396703 @default.
• W4327716795 hasRelatedWork W2153591790 @default.
• W4327716795 hasRelatedWork W2158288207 @default.
• W4327716795 hasRelatedWork W2161035911 @default.

• next