FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327733332> ?p ?o ?g. }

• W4327733332 abstract "Introduction The visual signals evoked at the retinal ganglion cells are modified and modulated by various synaptic inputs that impinge on lateral geniculate nucleus cells before they are sent to the cortex. The selectivity of geniculate inputs for clustering or forming microcircuits on discrete dendritic segments of geniculate cell types may provide the structural basis for network properties of the geniculate circuitry and differential signal processing through the parallel pathways of vision. In our study, we aimed to reveal the patterns of input selectivity on morphologically discernable relay cell types and interneurons in the mouse lateral geniculate nucleus. Methods We used two sets of Scanning Blockface Electron Microscopy (SBEM) image stacks and Reconstruct software to manually reconstruct of terminal boutons and dendrite segments. First, using an unbiased terminal sampling (UTS) approach and statistical modeling, we identified the criteria for volume-based sorting of geniculate boutons into their putative origins. Geniculate terminal boutons that were sorted in retinal and non-retinal categories based on previously described mitochondrial morphology, could further be sorted into multiple subpopulations based on their bouton volume distributions. Terminals deemed non-retinal based on the morphological criteria consisted of five distinct subpopulations, including small-sized putative corticothalamic and cholinergic boutons, two medium-sized putative GABAergic inputs, and a large-sized bouton type that contains dark mitochondria. Retinal terminals also consisted of four distinct subpopulations. The cutoff criteria for these subpopulations were then applied to datasets of terminals that synapse on reconstructed dendrite segments of relay cells or interneurons. Results Using a network analysis approach, we found an almost complete segregation of retinal and cortical terminals on putative X-type cell dendrite segments characterized by grape-like appendages and triads. On these cells, interneuron appendages intermingle with retinal and other medium size terminals to form triads within glomeruli. In contrast, a second, presumed Y-type cell displayed dendrodendritic puncta adherentia and received all terminal types without a selectivity for synapse location; these were not engaged in triads. Furthermore, the contribution of retinal and cortical synapses received by X-, Y- and interneuron dendrites differed such that over 60% of inputs to interneuron dendrites were from the retina, as opposed to 20% and 7% to X- and Y-type cells, respectively. Conclusion The results underlie differences in network properties of synaptic inputs from distinct origins on geniculate cell types." @default.
• W4327733332 created "2023-03-18" @default.
• W4327733332 creator A5000721031 @default.
• W4327733332 creator A5007519126 @default.
• W4327733332 creator A5029161045 @default.
• W4327733332 creator A5037504761 @default.
• W4327733332 creator A5043910258 @default.
• W4327733332 creator A5063855151 @default.
• W4327733332 date "2023-03-17" @default.
• W4327733332 modified "2023-10-05" @default.
• W4327733332 title "3D electron microscopy and volume-based bouton sorting reveal the selectivity of inputs onto geniculate relay cell and interneuron dendrite segments" @default.
• W4327733332 cites W102328726 @default.
• W4327733332 cites W1505641101 @default.
• W4327733332 cites W1530468053 @default.
• W4327733332 cites W1547228860 @default.
• W4327733332 cites W1554433559 @default.
• W4327733332 cites W1588092133 @default.
• W4327733332 cites W1748089690 @default.
• W4327733332 cites W1915286079 @default.
• W4327733332 cites W1967857491 @default.
• W4327733332 cites W1976225114 @default.
• W4327733332 cites W1976688362 @default.
• W4327733332 cites W1979386467 @default.
• W4327733332 cites W1980249569 @default.
• W4327733332 cites W1985260913 @default.
• W4327733332 cites W1988091387 @default.
• W4327733332 cites W1992102855 @default.
• W4327733332 cites W1993098607 @default.
• W4327733332 cites W2002302806 @default.
• W4327733332 cites W2007205208 @default.
• W4327733332 cites W2010395737 @default.
• W4327733332 cites W2012626950 @default.
• W4327733332 cites W2015633152 @default.
• W4327733332 cites W2016207758 @default.
• W4327733332 cites W2018640849 @default.
• W4327733332 cites W2018961236 @default.
• W4327733332 cites W2021284243 @default.
• W4327733332 cites W2025224767 @default.
• W4327733332 cites W2026634592 @default.
• W4327733332 cites W2028574924 @default.
• W4327733332 cites W2034570753 @default.
• W4327733332 cites W2037560994 @default.
• W4327733332 cites W2038665424 @default.
• W4327733332 cites W2041971833 @default.
• W4327733332 cites W2044937225 @default.
• W4327733332 cites W2052412695 @default.
• W4327733332 cites W2055066302 @default.
• W4327733332 cites W2057803094 @default.
• W4327733332 cites W2059390121 @default.
• W4327733332 cites W2066938409 @default.
• W4327733332 cites W2069398817 @default.
• W4327733332 cites W2070949315 @default.
• W4327733332 cites W2071961929 @default.
• W4327733332 cites W2074582446 @default.
• W4327733332 cites W2076891899 @default.
• W4327733332 cites W2077262024 @default.
• W4327733332 cites W2079041565 @default.
• W4327733332 cites W2082309506 @default.
• W4327733332 cites W2096884914 @default.
• W4327733332 cites W2105436594 @default.
• W4327733332 cites W2106875648 @default.
• W4327733332 cites W2112575206 @default.
• W4327733332 cites W2133610185 @default.
• W4327733332 cites W2136744674 @default.
• W4327733332 cites W2140066618 @default.
• W4327733332 cites W2142784661 @default.
• W4327733332 cites W2143454033 @default.
• W4327733332 cites W2148574157 @default.
• W4327733332 cites W2149208048 @default.
• W4327733332 cites W2156241606 @default.
• W4327733332 cites W2160406415 @default.
• W4327733332 cites W2162896254 @default.
• W4327733332 cites W2164443179 @default.
• W4327733332 cites W2174781702 @default.
• W4327733332 cites W2307899896 @default.
• W4327733332 cites W2310676124 @default.
• W4327733332 cites W2342920898 @default.
• W4327733332 cites W2401708274 @default.
• W4327733332 cites W2410869791 @default.
• W4327733332 cites W2411566356 @default.
• W4327733332 cites W2519132385 @default.
• W4327733332 cites W2589204293 @default.
• W4327733332 cites W2743807044 @default.
• W4327733332 cites W2789837649 @default.
• W4327733332 cites W2798025135 @default.
• W4327733332 cites W2810208530 @default.
• W4327733332 cites W2910817483 @default.
• W4327733332 cites W3010515960 @default.
• W4327733332 cites W3038922205 @default.
• W4327733332 cites W4200278314 @default.
• W4327733332 cites W4213214460 @default.
• W4327733332 cites W882375991 @default.
• W4327733332 doi "https://doi.org/10.3389/fnana.2023.1150747" @default.
• W4327733332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37007643" @default.
• W4327733332 hasPublicationYear "2023" @default.
• W4327733332 type Work @default.
• W4327733332 citedByCount "1" @default.
• W4327733332 crossrefType "journal-article" @default.
• W4327733332 hasAuthorship W4327733332A5000721031 @default.
• W4327733332 hasAuthorship W4327733332A5007519126 @default.

• next