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- W4327734978 abstract "The immune system coordinates the response to cardiac injury and is known to control regenerative and fibrotic scar outcomes in the heart and subsequent chronic low-grade inflammation associated with heart failure. Here we profiled the inflammatory response to heart injury using single cell transcriptomics to compare and contrast two experimental models with disparate outcomes. We used adult mice, which like humans lack the ability to fully recover and zebrafish which spontaneously regenerate after heart injury. The extracardiac reaction to cardiomyocyte necrosis was also interrogated to assess the specific peripheral tissue and immune cell reaction to chronic stress. Cardiac macrophages are known to play a critical role in determining tissue homeostasis by healing versus scarring. We identified distinct transcriptional clusters of monocytes/macrophages in each species and found analogous pairs in zebrafish and mice. However, the reaction to myocardial injury was largely disparate between mice and zebrafish. The dichotomous response to heart damage between the mammalian and zebrafish monocytes/macrophages may underlie the impaired regenerative process in mice, representing a future therapeutic target." @default.
- W4327734978 created "2023-03-18" @default.
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- W4327734978 date "2023-03-16" @default.
- W4327734978 modified "2023-09-26" @default.
- W4327734978 title "Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury" @default.
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- W4327734978 doi "https://doi.org/10.1101/2023.03.15.532865" @default.
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