Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327738700> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4327738700 endingPage "736" @default.
- W4327738700 startingPage "736" @default.
- W4327738700 abstract "Genotype-by-environment interactions (GEI) may influence dental caries, although their effects are difficult to detect. Variance quantitative trait loci (vQTL) may serve as an indicator of underlying GEI effects. The aim of this study was to investigate GEI effects on dental caries by prioritizing variants from genome-wide vQTL analysis. First, we identified vQTLs from ~4.3 M genome-wide variants in three cohorts of white children aged 3–5 (n = 396, n = 328, n = 773) using Levene’s test. A total of 39 independent vQTLs with p < 1 × 10−6 were identified, some of which were located in or near genes with plausible biological roles in dental caries (IGFBP7, SLC5A8, and SHH involved in tooth development and enamel mineralization). Next, we used linear regression to test GEI effects on dental caries with the 39 prioritized variants and self-reported environmental factors (demographic, socioeconomic, behavioral, and dietary factors) in the three cohorts separately. We identified eight significant GEIs indicating that children with vQTL risk genotypes had higher caries experience if they had less educated parents, lower household/parental income, brushed their teeth less frequently, consumed sugar-sweetened beverages more frequently, were not breastfed, and were female. We reported the first genome-wide vQTL analysis of dental caries in children nominating several novel genes and GEI for further investigations." @default.
- W4327738700 created "2023-03-18" @default.
- W4327738700 creator A5023251246 @default.
- W4327738700 creator A5033510739 @default.
- W4327738700 creator A5044858589 @default.
- W4327738700 creator A5059822764 @default.
- W4327738700 creator A5064886913 @default.
- W4327738700 creator A5089673217 @default.
- W4327738700 date "2023-03-17" @default.
- W4327738700 modified "2023-09-26" @default.
- W4327738700 title "Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions" @default.
- W4327738700 cites W1491358830 @default.
- W4327738700 cites W1520492412 @default.
- W4327738700 cites W1997117136 @default.
- W4327738700 cites W2013156215 @default.
- W4327738700 cites W2026839621 @default.
- W4327738700 cites W2056906503 @default.
- W4327738700 cites W2057726970 @default.
- W4327738700 cites W2076304978 @default.
- W4327738700 cites W2097400859 @default.
- W4327738700 cites W2104382557 @default.
- W4327738700 cites W2118108490 @default.
- W4327738700 cites W2133520037 @default.
- W4327738700 cites W2146575395 @default.
- W4327738700 cites W2175680200 @default.
- W4327738700 cites W2256302415 @default.
- W4327738700 cites W2417157940 @default.
- W4327738700 cites W2474827345 @default.
- W4327738700 cites W2510973425 @default.
- W4327738700 cites W2511515754 @default.
- W4327738700 cites W2524718987 @default.
- W4327738700 cites W2728017684 @default.
- W4327738700 cites W2947736529 @default.
- W4327738700 cites W2952784561 @default.
- W4327738700 cites W3006959386 @default.
- W4327738700 cites W3096113595 @default.
- W4327738700 cites W3111318171 @default.
- W4327738700 doi "https://doi.org/10.3390/genes14030736" @default.
- W4327738700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36981009" @default.
- W4327738700 hasPublicationYear "2023" @default.
- W4327738700 type Work @default.
- W4327738700 citedByCount "0" @default.
- W4327738700 crossrefType "journal-article" @default.
- W4327738700 hasAuthorship W4327738700A5023251246 @default.
- W4327738700 hasAuthorship W4327738700A5033510739 @default.
- W4327738700 hasAuthorship W4327738700A5044858589 @default.
- W4327738700 hasAuthorship W4327738700A5059822764 @default.
- W4327738700 hasAuthorship W4327738700A5064886913 @default.
- W4327738700 hasAuthorship W4327738700A5089673217 @default.
- W4327738700 hasBestOaLocation W43277387001 @default.
- W4327738700 hasConcept C104317684 @default.
- W4327738700 hasConcept C126322002 @default.
- W4327738700 hasConcept C130947863 @default.
- W4327738700 hasConcept C135763542 @default.
- W4327738700 hasConcept C141231307 @default.
- W4327738700 hasConcept C147077947 @default.
- W4327738700 hasConcept C199343813 @default.
- W4327738700 hasConcept C2908647359 @default.
- W4327738700 hasConcept C2991849382 @default.
- W4327738700 hasConcept C54355233 @default.
- W4327738700 hasConcept C71924100 @default.
- W4327738700 hasConcept C86803240 @default.
- W4327738700 hasConcept C99454951 @default.
- W4327738700 hasConcept C99476002 @default.
- W4327738700 hasConceptScore W4327738700C104317684 @default.
- W4327738700 hasConceptScore W4327738700C126322002 @default.
- W4327738700 hasConceptScore W4327738700C130947863 @default.
- W4327738700 hasConceptScore W4327738700C135763542 @default.
- W4327738700 hasConceptScore W4327738700C141231307 @default.
- W4327738700 hasConceptScore W4327738700C147077947 @default.
- W4327738700 hasConceptScore W4327738700C199343813 @default.
- W4327738700 hasConceptScore W4327738700C2908647359 @default.
- W4327738700 hasConceptScore W4327738700C2991849382 @default.
- W4327738700 hasConceptScore W4327738700C54355233 @default.
- W4327738700 hasConceptScore W4327738700C71924100 @default.
- W4327738700 hasConceptScore W4327738700C86803240 @default.
- W4327738700 hasConceptScore W4327738700C99454951 @default.
- W4327738700 hasConceptScore W4327738700C99476002 @default.
- W4327738700 hasIssue "3" @default.
- W4327738700 hasLocation W43277387001 @default.
- W4327738700 hasLocation W43277387002 @default.
- W4327738700 hasLocation W43277387003 @default.
- W4327738700 hasOpenAccess W4327738700 @default.
- W4327738700 hasPrimaryLocation W43277387001 @default.
- W4327738700 hasRelatedWork W1828691184 @default.
- W4327738700 hasRelatedWork W1903732681 @default.
- W4327738700 hasRelatedWork W1991523530 @default.
- W4327738700 hasRelatedWork W2002128513 @default.
- W4327738700 hasRelatedWork W2020824267 @default.
- W4327738700 hasRelatedWork W2030640333 @default.
- W4327738700 hasRelatedWork W2057739827 @default.
- W4327738700 hasRelatedWork W2075354549 @default.
- W4327738700 hasRelatedWork W2903807872 @default.
- W4327738700 hasRelatedWork W2092874662 @default.
- W4327738700 hasVolume "14" @default.
- W4327738700 isParatext "false" @default.
- W4327738700 isRetracted "false" @default.
- W4327738700 workType "article" @default.