Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327744356> ?p ?o ?g. }
- W4327744356 abstract "Integrative analyses of transcriptomic and neuroimaging data have generated a wealth of information about biological pathways underlying regional variability in imaging-derived brain phenotypes in humans, but rarely in nonhuman primates due to the lack of a comprehensive anatomically-defined atlas of brain transcriptomics. Here we generate complementary bulk RNA-sequencing dataset of 819 samples from 110 brain regions and single-nucleus RNA-sequencing dataset, and neuroimaging data from 162 cynomolgus macaques, to examine the link between brain-wide gene expression and regional variation in morphometry. We not only observe global/regional expression profiles of macaque brain comparable to human but unravel a dorsolateral-ventromedial gradient of gene assemblies within the primate frontal lobe. Furthermore, we identify a set of 971 protein-coding and 34 non-coding genes consistently associated with cortical thickness, specially enriched for neurons and oligodendrocytes. These data provide a unique resource to investigate nonhuman primate models of human diseases and probe cross-species evolutionary mechanisms." @default.
- W4327744356 created "2023-03-18" @default.
- W4327744356 creator A5000963958 @default.
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- W4327744356 creator A5072900720 @default.
- W4327744356 creator A5078039755 @default.
- W4327744356 date "2023-03-17" @default.
- W4327744356 modified "2023-10-17" @default.
- W4327744356 title "Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys" @default.
- W4327744356 cites W1939589473 @default.
- W4327744356 cites W1966327575 @default.
- W4327744356 cites W1984714101 @default.
- W4327744356 cites W1986748157 @default.
- W4327744356 cites W1988975078 @default.
- W4327744356 cites W1989119979 @default.
- W4327744356 cites W1999574084 @default.
- W4327744356 cites W2022689242 @default.
- W4327744356 cites W2024862524 @default.
- W4327744356 cites W2029287634 @default.
- W4327744356 cites W2035550470 @default.
- W4327744356 cites W2045419273 @default.
- W4327744356 cites W2055655674 @default.
- W4327744356 cites W2059429138 @default.
- W4327744356 cites W2060705109 @default.
- W4327744356 cites W2064274168 @default.
- W4327744356 cites W2066470779 @default.
- W4327744356 cites W2081837126 @default.
- W4327744356 cites W2089817334 @default.
- W4327744356 cites W2122926243 @default.
- W4327744356 cites W2123491442 @default.
- W4327744356 cites W2138207763 @default.
- W4327744356 cites W2138728868 @default.
- W4327744356 cites W2146512944 @default.
- W4327744356 cites W2156247618 @default.
- W4327744356 cites W2163302580 @default.
- W4327744356 cites W2169101662 @default.
- W4327744356 cites W2169456326 @default.
- W4327744356 cites W2170219300 @default.
- W4327744356 cites W2179438025 @default.
- W4327744356 cites W2236822143 @default.
- W4327744356 cites W2260830658 @default.
- W4327744356 cites W2261151942 @default.
- W4327744356 cites W2346576232 @default.
- W4327744356 cites W2472012926 @default.
- W4327744356 cites W2497939844 @default.
- W4327744356 cites W2499800833 @default.
- W4327744356 cites W2514222651 @default.
- W4327744356 cites W2587061236 @default.
- W4327744356 cites W2616922646 @default.
- W4327744356 cites W2742494644 @default.
- W4327744356 cites W2762363694 @default.
- W4327744356 cites W2766981877 @default.
- W4327744356 cites W2768745187 @default.
- W4327744356 cites W2773293192 @default.
- W4327744356 cites W2784003079 @default.
- W4327744356 cites W2792073521 @default.
- W4327744356 cites W2800243708 @default.
- W4327744356 cites W2895693082 @default.
- W4327744356 cites W2897300390 @default.
- W4327744356 cites W2902652978 @default.
- W4327744356 cites W2903689387 @default.
- W4327744356 cites W2908065686 @default.
- W4327744356 cites W2917884516 @default.
- W4327744356 cites W2928665623 @default.
- W4327744356 cites W2930394955 @default.
- W4327744356 cites W2944545583 @default.
- W4327744356 cites W2950447704 @default.
- W4327744356 cites W2951722595 @default.
- W4327744356 cites W2965280594 @default.
- W4327744356 cites W2969948459 @default.
- W4327744356 cites W2976878096 @default.
- W4327744356 cites W2978356506 @default.
- W4327744356 cites W2990232101 @default.
- W4327744356 cites W2990766062 @default.
- W4327744356 cites W2996073934 @default.
- W4327744356 cites W3011154449 @default.
- W4327744356 cites W3015297113 @default.
- W4327744356 cites W3015507869 @default.
- W4327744356 cites W3035841897 @default.
- W4327744356 cites W3036081205 @default.
- W4327744356 cites W3077433246 @default.
- W4327744356 cites W3080158422 @default.
- W4327744356 cites W3080178531 @default.
- W4327744356 cites W3083962177 @default.
- W4327744356 cites W3089036867 @default.
- W4327744356 cites W3092186529 @default.
- W4327744356 cites W3130593045 @default.
- W4327744356 cites W3134734702 @default.
- W4327744356 cites W3142292409 @default.
- W4327744356 cites W3164692211 @default.
- W4327744356 cites W3204443805 @default.