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- W4327744363 endingPage "1990" @default.
- W4327744363 startingPage "1981" @default.
- W4327744363 abstract "Gastrointestinal (GI) cancers account for 35% of cancer-related deaths, predominantly due to their ability to spread and generate drug-tolerant metastases. Arising from different locations in the GI system, the majority of metastatic GI malignancies colonise the liver and the lungs. In this context, circulating tumour cells (CTCs) are playing a critical role in the formation of new metastases, and their presence in the blood of patients has been correlated with a poor outcome. In addition to their prognostic utility, prospective targeting of CTCs may represent a novel, yet ambitious strategy in the fight against metastasis. A better understanding of CTC biology, mechanistic underpinnings and weaknesses may facilitate the development of previously underappreciated anti-metastasis approaches. Here, along with related clinical studies, we outline a selection of the literature describing biological features of CTCs with an impact on their metastasis forming ability in different GI cancers." @default.
- W4327744363 created "2023-03-18" @default.
- W4327744363 creator A5037415753 @default.
- W4327744363 creator A5055122484 @default.
- W4327744363 creator A5084595779 @default.
- W4327744363 creator A5086884279 @default.
- W4327744363 date "2023-03-17" @default.
- W4327744363 modified "2023-10-17" @default.
- W4327744363 title "Circulating tumour cells in gastrointestinal cancers: food for thought?" @default.
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