FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327831294> ?p ?o ?g. }

• W4327831294 endingPage "104516" @default.
• W4327831294 startingPage "104516" @default.
• W4327831294 abstract "This study was conducted to investigate the cascade involving DNA damage, senescence, and senescence-associated secretory phenotype (SASP) in experimental diabetes and in a four-year follow-up study in patients with pre-diabetes and type 2 diabetes.Kidney, lung, and liver were studied in 4 months diabetic db/db mice and age-matched controls for the presence of DNA damage and fibrosis. DNA damage (comet-tail-length and ɤH2Ax-positivity in white blood cells), urinary p21-excretion, and plasma IL-6 and TGF-β1 were determined from 115 healthy participants, 34 patients with pre-diabetes and 221 with type 2 diabetes. Urinary albumin-creatinine-ratio, lung function, and transient elastography of the liver were performed in a prospective follow-up study over 4 years.db/db mice showed an increased nuclear ɤH2AX signal in all tissues as compared to the background control. Markers for DNA damage, senescence, and SASP were increased in patients with diabetes. The presence of nephropathy, restrictive lung disease (RLD), and increased liver stiffness was in a cross-sectional design associated with increased markers for DNA damage, senescence, and SASP. The progression of nephropathy over 4 years was predicted by increased DNA damage, senescence, and SASP, while the progression of RLD was associated with increased DNA damage and IL-6 only. The progression of liver stiffness was not associated with any of these parameters. HbA1c was not predictive for progression.In db/db mice, the cascade of DNA damage is associated with diabetes-related complications. In patients with diabetes, the progression of complications in the kidney and lung is predicted by markers reflecting DNA damage, and senescence-triggered organ fibrosis.This work was supported by the German Research Foundation (DFG) in the CRC 1118 and CRC 1158, by the GRK DIAMICOM, by the German Center for Diabetes Research (DZD e.V.), and by the Ministry of Science, Research and the Arts, Baden-Württemberg (Kompetenznetzwerk Präventivmedizin)." @default.
• W4327831294 created "2023-03-19" @default.
• W4327831294 creator A5003782256 @default.
• W4327831294 creator A5010949916 @default.
• W4327831294 creator A5011751065 @default.
• W4327831294 creator A5021980795 @default.
• W4327831294 creator A5025170171 @default.
• W4327831294 creator A5035245236 @default.
• W4327831294 creator A5051845993 @default.
• W4327831294 creator A5059231730 @default.
• W4327831294 creator A5063438147 @default.
• W4327831294 creator A5067599146 @default.
• W4327831294 creator A5070746745 @default.
• W4327831294 creator A5070808932 @default.
• W4327831294 creator A5077589053 @default.
• W4327831294 creator A5082040735 @default.
• W4327831294 creator A5087254182 @default.
• W4327831294 date "2023-04-01" @default.
• W4327831294 modified "2023-09-27" @default.
• W4327831294 title "Elevated markers of DNA damage and senescence are associated with the progression of albuminuria and restrictive lung disease in patients with type 2 diabetes" @default.
• W4327831294 cites W1495307414 @default.
• W4327831294 cites W1500301819 @default.
• W4327831294 cites W1545181609 @default.
• W4327831294 cites W1966544205 @default.
• W4327831294 cites W1971592508 @default.
• W4327831294 cites W1973185447 @default.
• W4327831294 cites W2011735401 @default.
• W4327831294 cites W2031017520 @default.
• W4327831294 cites W2032524530 @default.
• W4327831294 cites W2035847235 @default.
• W4327831294 cites W2037180034 @default.
• W4327831294 cites W2048128034 @default.
• W4327831294 cites W2048777894 @default.
• W4327831294 cites W2078519775 @default.
• W4327831294 cites W2090296094 @default.
• W4327831294 cites W2107674471 @default.
• W4327831294 cites W2116054786 @default.
• W4327831294 cites W2118760722 @default.
• W4327831294 cites W2119960010 @default.
• W4327831294 cites W2124879124 @default.
• W4327831294 cites W2126699286 @default.
• W4327831294 cites W2136575869 @default.
• W4327831294 cites W2165747324 @default.
• W4327831294 cites W2167464044 @default.
• W4327831294 cites W2561824302 @default.
• W4327831294 cites W2606658423 @default.
• W4327831294 cites W2608769407 @default.
• W4327831294 cites W2741981472 @default.
• W4327831294 cites W2742001951 @default.
• W4327831294 cites W2745032521 @default.
• W4327831294 cites W2781490247 @default.
• W4327831294 cites W2790501791 @default.
• W4327831294 cites W2805042091 @default.
• W4327831294 cites W2887427549 @default.
• W4327831294 cites W2899064970 @default.
• W4327831294 cites W2901235303 @default.
• W4327831294 cites W2903169176 @default.
• W4327831294 cites W2906120852 @default.
• W4327831294 cites W2913327680 @default.
• W4327831294 cites W2918970486 @default.
• W4327831294 cites W2924101029 @default.
• W4327831294 cites W2947927825 @default.
• W4327831294 cites W2963049843 @default.
• W4327831294 cites W2964211103 @default.
• W4327831294 cites W2973692277 @default.
• W4327831294 cites W2977880419 @default.
• W4327831294 cites W2995343921 @default.
• W4327831294 cites W3020516177 @default.
• W4327831294 cites W3025858593 @default.
• W4327831294 cites W3046433615 @default.
• W4327831294 cites W3082844838 @default.
• W4327831294 cites W3120205736 @default.
• W4327831294 cites W3121016581 @default.
• W4327831294 cites W3124793622 @default.
• W4327831294 cites W3200562012 @default.
• W4327831294 cites W3217556743 @default.
• W4327831294 cites W4238009561 @default.
• W4327831294 cites W4281696305 @default.
• W4327831294 cites W4293354575 @default.
• W4327831294 cites W4321478526 @default.
• W4327831294 doi "https://doi.org/10.1016/j.ebiom.2023.104516" @default.
• W4327831294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36934657" @default.
• W4327831294 hasPublicationYear "2023" @default.
• W4327831294 type Work @default.
• W4327831294 citedByCount "2" @default.
• W4327831294 countsByYear W43278312942023 @default.
• W4327831294 crossrefType "journal-article" @default.
• W4327831294 hasAuthorship W4327831294A5003782256 @default.
• W4327831294 hasAuthorship W4327831294A5010949916 @default.
• W4327831294 hasAuthorship W4327831294A5011751065 @default.
• W4327831294 hasAuthorship W4327831294A5021980795 @default.
• W4327831294 hasAuthorship W4327831294A5025170171 @default.
• W4327831294 hasAuthorship W4327831294A5035245236 @default.
• W4327831294 hasAuthorship W4327831294A5051845993 @default.
• W4327831294 hasAuthorship W4327831294A5059231730 @default.
• W4327831294 hasAuthorship W4327831294A5063438147 @default.
• W4327831294 hasAuthorship W4327831294A5067599146 @default.
• W4327831294 hasAuthorship W4327831294A5070746745 @default.

• next