Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327831330> ?p ?o ?g. }
- W4327831330 abstract "Abstract Ischaemic heart disease is a global healthcare challenge with high morbidity and mortality. Early revascularisation in acute myocardial infarction has improved survival, however, limited regenerative capacity and microvascular dysfunction often lead to impaired function and the development of heart failure. New mechanistic insights are required to identify robust targets for the development of novel strategies to promote regeneration. Single cell RNA sequencing (scRNA-seq) has enabled profiling and analysis of the transcriptomes of individual cells at high resolution. Applications of scRNA-seq have generated single cell atlases for multiple species, revealed distinct cellular compositions for different regions of the heart, and defined multiple mechanisms involved in myocardial injury-induced regeneration. In this review, we summarise findings from studies of healthy and injured hearts in multiple species and spanning different developmental stages. Based on this transformative technology, we propose a multi-species, multi-omics, meta-analysis framework to drive the discovery of new targets to promote cardiovascular regeneration." @default.
- W4327831330 created "2023-03-19" @default.
- W4327831330 creator A5025485683 @default.
- W4327831330 creator A5067717934 @default.
- W4327831330 creator A5069583505 @default.
- W4327831330 date "2023-03-17" @default.
- W4327831330 modified "2023-10-14" @default.
- W4327831330 title "A multimodal omics framework to empower target discovery for cardiovascular regeneration" @default.
- W4327831330 cites W1578501129 @default.
- W4327831330 cites W1969038150 @default.
- W4327831330 cites W1974047233 @default.
- W4327831330 cites W1981509058 @default.
- W4327831330 cites W2036876430 @default.
- W4327831330 cites W2096907419 @default.
- W4327831330 cites W2098455751 @default.
- W4327831330 cites W2105935043 @default.
- W4327831330 cites W2125987139 @default.
- W4327831330 cites W2126747203 @default.
- W4327831330 cites W2149573463 @default.
- W4327831330 cites W2153539103 @default.
- W4327831330 cites W2522665294 @default.
- W4327831330 cites W2610602137 @default.
- W4327831330 cites W2736398804 @default.
- W4327831330 cites W2783252067 @default.
- W4327831330 cites W2790649837 @default.
- W4327831330 cites W2792649309 @default.
- W4327831330 cites W2807588107 @default.
- W4327831330 cites W2809205318 @default.
- W4327831330 cites W2884217607 @default.
- W4327831330 cites W2894687190 @default.
- W4327831330 cites W2912654919 @default.
- W4327831330 cites W2924188812 @default.
- W4327831330 cites W2948414306 @default.
- W4327831330 cites W2995700709 @default.
- W4327831330 cites W2996171578 @default.
- W4327831330 cites W2999577865 @default.
- W4327831330 cites W3006650868 @default.
- W4327831330 cites W3007368813 @default.
- W4327831330 cites W3007723686 @default.
- W4327831330 cites W3013731060 @default.
- W4327831330 cites W3017880759 @default.
- W4327831330 cites W3025989739 @default.
- W4327831330 cites W3035532128 @default.
- W4327831330 cites W3080668573 @default.
- W4327831330 cites W3088401235 @default.
- W4327831330 cites W3111084394 @default.
- W4327831330 cites W3119379269 @default.
- W4327831330 cites W3119868047 @default.
- W4327831330 cites W3120937665 @default.
- W4327831330 cites W3128961456 @default.
- W4327831330 cites W3139601120 @default.
- W4327831330 cites W3153732845 @default.
- W4327831330 cites W3159211542 @default.
- W4327831330 cites W3163348136 @default.
- W4327831330 cites W3166165128 @default.
- W4327831330 cites W3166627873 @default.
- W4327831330 cites W3174148568 @default.
- W4327831330 cites W3177497024 @default.
- W4327831330 cites W3181267383 @default.
- W4327831330 cites W3196411720 @default.
- W4327831330 cites W3197245431 @default.
- W4327831330 cites W3200928356 @default.
- W4327831330 cites W3202571733 @default.
- W4327831330 cites W3207498177 @default.
- W4327831330 cites W4200296738 @default.
- W4327831330 cites W4210783294 @default.
- W4327831330 cites W4220765144 @default.
- W4327831330 cites W4224213994 @default.
- W4327831330 cites W4226270341 @default.
- W4327831330 cites W4280598116 @default.
- W4327831330 cites W4282932514 @default.
- W4327831330 cites W4283257569 @default.
- W4327831330 cites W4283390936 @default.
- W4327831330 cites W4286560334 @default.
- W4327831330 cites W4286716663 @default.
- W4327831330 cites W4289793679 @default.
- W4327831330 cites W4290989128 @default.
- W4327831330 cites W4295088077 @default.
- W4327831330 cites W4295951577 @default.
- W4327831330 cites W4297243391 @default.
- W4327831330 cites W4302293110 @default.
- W4327831330 cites W4308834549 @default.
- W4327831330 cites W4311154294 @default.
- W4327831330 cites W4311387214 @default.
- W4327831330 cites W4313826026 @default.
- W4327831330 cites W4317234401 @default.
- W4327831330 doi "https://doi.org/10.21203/rs.3.rs-2661638/v1" @default.
- W4327831330 hasPublicationYear "2023" @default.
- W4327831330 type Work @default.
- W4327831330 citedByCount "0" @default.
- W4327831330 crossrefType "posted-content" @default.
- W4327831330 hasAuthorship W4327831330A5025485683 @default.
- W4327831330 hasAuthorship W4327831330A5067717934 @default.
- W4327831330 hasAuthorship W4327831330A5069583505 @default.
- W4327831330 hasBestOaLocation W43278313301 @default.
- W4327831330 hasConcept C104317684 @default.
- W4327831330 hasConcept C111919701 @default.
- W4327831330 hasConcept C142724271 @default.
- W4327831330 hasConcept C150194340 @default.
- W4327831330 hasConcept C15744967 @default.