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- W4327861844 abstract "Abstract Combinatorial expression of postsynaptic proteins underlies synapse diversity within and between neuron types 1-5 . Thus, characterization of neuron-type-specific postsynaptic proteomes is key to obtaining a deeper understanding of discrete synaptic properties and how selective dysfunction manifests in synaptopathies 6-9 . To overcome the limitations associated with bulk measures of synaptic protein abundance 6,10 , we developed a biotin proximity protein tagging probe to characterize neuron-type-specific postsynaptic proteomes in vivo . We found Shank3 protein isoforms are differentially expressed by direct and indirect pathway spiny projection neurons (dSPNs and iSPNs). Studies in mice lacking Shank3 gene exons 13-16 revealed a robust postsynaptic proteome alteration in iSPNs. We report unexpected cell-type specific synaptic protein isoform expression which could play a key causal role in specifying synapse diversity and selective synapse dysfunction in synaptopathies." @default.
- W4327861844 created "2023-03-20" @default.
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- W4327861844 date "2023-03-17" @default.
- W4327861844 modified "2023-10-18" @default.
- W4327861844 title "Neuron-specific protein expression at striatal excitatory synapses" @default.
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- W4327861844 doi "https://doi.org/10.1101/2023.03.16.532957" @default.
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