Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327862425> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4327862425 abstract "Abstract The discovery of bioactive natural products lies at the forefront of human medicine. The continued discovery of these molecules is imperative in the fight against infection and disease. While natural products have historically dominated the drug market, discovery in recent years has slowed significantly, partly due to limitations in current discovery methodologies. This work demonstrates a new workflow, Deuterium Adduct Bioactivity Screening (DABS), which pairs untargeted isotope labeling with whole cell binding assays for bioactive natural product discovery. DABS was validated and led to the discovery of a new isoprenyl guanidine alkaloid, zillamycin, which showed anti-cancer and anti-microbial activities. DABS thus represents a new workflow to accelerate discovery of natural products with a wide range of bioactive potential." @default.
- W4327862425 created "2023-03-20" @default.
- W4327862425 creator A5002020988 @default.
- W4327862425 creator A5002855955 @default.
- W4327862425 creator A5007797750 @default.
- W4327862425 creator A5020884371 @default.
- W4327862425 creator A5026354170 @default.
- W4327862425 creator A5081117163 @default.
- W4327862425 date "2023-03-17" @default.
- W4327862425 modified "2023-09-30" @default.
- W4327862425 title "Bioactive Natural Product Discovery via Deuterium Adduct Bioactivity Screening" @default.
- W4327862425 cites W1570643690 @default.
- W4327862425 cites W1923982689 @default.
- W4327862425 cites W1988967696 @default.
- W4327862425 cites W1990555250 @default.
- W4327862425 cites W1993748050 @default.
- W4327862425 cites W2007559738 @default.
- W4327862425 cites W2020265334 @default.
- W4327862425 cites W2028843992 @default.
- W4327862425 cites W2045522994 @default.
- W4327862425 cites W2076115910 @default.
- W4327862425 cites W2080632083 @default.
- W4327862425 cites W2082891742 @default.
- W4327862425 cites W2113790776 @default.
- W4327862425 cites W2221529903 @default.
- W4327862425 cites W2290518567 @default.
- W4327862425 cites W2504691963 @default.
- W4327862425 cites W2623609424 @default.
- W4327862425 cites W2792690368 @default.
- W4327862425 cites W2883269759 @default.
- W4327862425 cites W2941686397 @default.
- W4327862425 cites W2948730929 @default.
- W4327862425 cites W2957932170 @default.
- W4327862425 cites W2978958386 @default.
- W4327862425 cites W3000908334 @default.
- W4327862425 cites W3011366455 @default.
- W4327862425 cites W3112506902 @default.
- W4327862425 cites W3123108595 @default.
- W4327862425 cites W3158912068 @default.
- W4327862425 cites W3175669157 @default.
- W4327862425 cites W3196903026 @default.
- W4327862425 cites W3201475823 @default.
- W4327862425 cites W3210852361 @default.
- W4327862425 cites W3216402340 @default.
- W4327862425 cites W4200557024 @default.
- W4327862425 cites W4210514288 @default.
- W4327862425 cites W4245367233 @default.
- W4327862425 cites W4250203876 @default.
- W4327862425 doi "https://doi.org/10.1101/2023.03.16.532988" @default.
- W4327862425 hasPublicationYear "2023" @default.
- W4327862425 type Work @default.
- W4327862425 citedByCount "0" @default.
- W4327862425 crossrefType "posted-content" @default.
- W4327862425 hasAuthorship W4327862425A5002020988 @default.
- W4327862425 hasAuthorship W4327862425A5002855955 @default.
- W4327862425 hasAuthorship W4327862425A5007797750 @default.
- W4327862425 hasAuthorship W4327862425A5020884371 @default.
- W4327862425 hasAuthorship W4327862425A5026354170 @default.
- W4327862425 hasAuthorship W4327862425A5081117163 @default.
- W4327862425 hasBestOaLocation W43278624251 @default.
- W4327862425 hasConcept C108204754 @default.
- W4327862425 hasConcept C178790620 @default.
- W4327862425 hasConcept C185592680 @default.
- W4327862425 hasConcept C21951064 @default.
- W4327862425 hasConcept C2779396153 @default.
- W4327862425 hasConcept C55493867 @default.
- W4327862425 hasConcept C70721500 @default.
- W4327862425 hasConcept C74187038 @default.
- W4327862425 hasConcept C86803240 @default.
- W4327862425 hasConcept C99726746 @default.
- W4327862425 hasConceptScore W4327862425C108204754 @default.
- W4327862425 hasConceptScore W4327862425C178790620 @default.
- W4327862425 hasConceptScore W4327862425C185592680 @default.
- W4327862425 hasConceptScore W4327862425C21951064 @default.
- W4327862425 hasConceptScore W4327862425C2779396153 @default.
- W4327862425 hasConceptScore W4327862425C55493867 @default.
- W4327862425 hasConceptScore W4327862425C70721500 @default.
- W4327862425 hasConceptScore W4327862425C74187038 @default.
- W4327862425 hasConceptScore W4327862425C86803240 @default.
- W4327862425 hasConceptScore W4327862425C99726746 @default.
- W4327862425 hasLocation W43278624251 @default.
- W4327862425 hasLocation W43278624252 @default.
- W4327862425 hasOpenAccess W4327862425 @default.
- W4327862425 hasPrimaryLocation W43278624251 @default.
- W4327862425 hasRelatedWork W1981508461 @default.
- W4327862425 hasRelatedWork W2041808719 @default.
- W4327862425 hasRelatedWork W2319385086 @default.
- W4327862425 hasRelatedWork W2580346700 @default.
- W4327862425 hasRelatedWork W2593711404 @default.
- W4327862425 hasRelatedWork W2597182293 @default.
- W4327862425 hasRelatedWork W2772041094 @default.
- W4327862425 hasRelatedWork W2923110034 @default.
- W4327862425 hasRelatedWork W3003656562 @default.
- W4327862425 hasRelatedWork W4296087771 @default.
- W4327862425 isParatext "false" @default.
- W4327862425 isRetracted "false" @default.
- W4327862425 workType "article" @default.