Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327862521> ?p ?o ?g. }
- W4327862521 abstract "Abstract Bacillus Calmette–Guérin (BCG) remains the only clinically approved tuberculosis (TB) vaccine despite limited efficacy. Preclinical studies of next generation TB vaccines have typically used a murine aerosol challenge model that employs a high supraphysiologic challenge dose. Here we show that the protective efficacy of a live attenuated Mycobacterium tuberculosis (Mtb) vaccine candidate ΔLprG markedly exceeds that of BCG in a low dose murine aerosol challenge model. BCG vaccination reduced bacterial loads but failed to prevent establishment or dissemination of infection in this model. In contrast, ΔLprG prevented detectable infection in 61% of mice and resulted in striking anatomic containment of 100% breakthrough infections to a single lung. Protection was partially abrogated in a repeated low dose challenge model, which revealed serum IL-17A, IL-6, CXCL2, CCL2, IFN-γ, and CXCL1 as correlates of protection. These data demonstrate that ΔLprG provides strikingly increased protection compared to BCG, including reduced detectable infection and anatomic containment, in a low dose murine challenge model." @default.
- W4327862521 created "2023-03-20" @default.
- W4327862521 creator A5015246989 @default.
- W4327862521 creator A5033016281 @default.
- W4327862521 creator A5033349542 @default.
- W4327862521 creator A5034722036 @default.
- W4327862521 creator A5054247332 @default.
- W4327862521 creator A5056039945 @default.
- W4327862521 creator A5071269385 @default.
- W4327862521 creator A5074122609 @default.
- W4327862521 creator A5074292548 @default.
- W4327862521 creator A5075715453 @default.
- W4327862521 creator A5075848661 @default.
- W4327862521 creator A5077334608 @default.
- W4327862521 creator A5080121245 @default.
- W4327862521 creator A5083232975 @default.
- W4327862521 date "2023-03-18" @default.
- W4327862521 modified "2023-09-27" @default.
- W4327862521 title "Attenuated<i>Mycobacterium tuberculosis</i>Vaccine Protection in a Low Dose Murine Challenge Model" @default.
- W4327862521 cites W1582232949 @default.
- W4327862521 cites W1974810704 @default.
- W4327862521 cites W1994971990 @default.
- W4327862521 cites W2065791817 @default.
- W4327862521 cites W2075271267 @default.
- W4327862521 cites W2092448486 @default.
- W4327862521 cites W2109484445 @default.
- W4327862521 cites W2130046741 @default.
- W4327862521 cites W2132657101 @default.
- W4327862521 cites W2157559696 @default.
- W4327862521 cites W2233241933 @default.
- W4327862521 cites W2737860676 @default.
- W4327862521 cites W2765354416 @default.
- W4327862521 cites W2885878894 @default.
- W4327862521 cites W2902919627 @default.
- W4327862521 cites W2910312028 @default.
- W4327862521 cites W2942178182 @default.
- W4327862521 cites W2945315710 @default.
- W4327862521 cites W3096604220 @default.
- W4327862521 cites W3111616436 @default.
- W4327862521 cites W3164808722 @default.
- W4327862521 cites W3194604363 @default.
- W4327862521 cites W4200240829 @default.
- W4327862521 cites W4214566749 @default.
- W4327862521 cites W4225137247 @default.
- W4327862521 cites W4313333757 @default.
- W4327862521 cites W4313368449 @default.
- W4327862521 doi "https://doi.org/10.1101/2023.03.17.533226" @default.
- W4327862521 hasPublicationYear "2023" @default.
- W4327862521 type Work @default.
- W4327862521 citedByCount "0" @default.
- W4327862521 crossrefType "posted-content" @default.
- W4327862521 hasAuthorship W4327862521A5015246989 @default.
- W4327862521 hasAuthorship W4327862521A5033016281 @default.
- W4327862521 hasAuthorship W4327862521A5033349542 @default.
- W4327862521 hasAuthorship W4327862521A5034722036 @default.
- W4327862521 hasAuthorship W4327862521A5054247332 @default.
- W4327862521 hasAuthorship W4327862521A5056039945 @default.
- W4327862521 hasAuthorship W4327862521A5071269385 @default.
- W4327862521 hasAuthorship W4327862521A5074122609 @default.
- W4327862521 hasAuthorship W4327862521A5074292548 @default.
- W4327862521 hasAuthorship W4327862521A5075715453 @default.
- W4327862521 hasAuthorship W4327862521A5075848661 @default.
- W4327862521 hasAuthorship W4327862521A5077334608 @default.
- W4327862521 hasAuthorship W4327862521A5080121245 @default.
- W4327862521 hasAuthorship W4327862521A5083232975 @default.
- W4327862521 hasBestOaLocation W43278625211 @default.
- W4327862521 hasConcept C13373296 @default.
- W4327862521 hasConcept C142724271 @default.
- W4327862521 hasConcept C159047783 @default.
- W4327862521 hasConcept C203014093 @default.
- W4327862521 hasConcept C22070199 @default.
- W4327862521 hasConcept C2777975735 @default.
- W4327862521 hasConcept C2778288313 @default.
- W4327862521 hasConcept C2779078216 @default.
- W4327862521 hasConcept C2781069245 @default.
- W4327862521 hasConcept C71924100 @default.
- W4327862521 hasConcept C86803240 @default.
- W4327862521 hasConcept C8891405 @default.
- W4327862521 hasConcept C89423630 @default.
- W4327862521 hasConcept C96525457 @default.
- W4327862521 hasConceptScore W4327862521C13373296 @default.
- W4327862521 hasConceptScore W4327862521C142724271 @default.
- W4327862521 hasConceptScore W4327862521C159047783 @default.
- W4327862521 hasConceptScore W4327862521C203014093 @default.
- W4327862521 hasConceptScore W4327862521C22070199 @default.
- W4327862521 hasConceptScore W4327862521C2777975735 @default.
- W4327862521 hasConceptScore W4327862521C2778288313 @default.
- W4327862521 hasConceptScore W4327862521C2779078216 @default.
- W4327862521 hasConceptScore W4327862521C2781069245 @default.
- W4327862521 hasConceptScore W4327862521C71924100 @default.
- W4327862521 hasConceptScore W4327862521C86803240 @default.
- W4327862521 hasConceptScore W4327862521C8891405 @default.
- W4327862521 hasConceptScore W4327862521C89423630 @default.
- W4327862521 hasConceptScore W4327862521C96525457 @default.
- W4327862521 hasLocation W43278625211 @default.
- W4327862521 hasOpenAccess W4327862521 @default.
- W4327862521 hasPrimaryLocation W43278625211 @default.
- W4327862521 hasRelatedWork W1969822700 @default.
- W4327862521 hasRelatedWork W1996891055 @default.
- W4327862521 hasRelatedWork W2002916173 @default.