Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327894037> ?p ?o ?g. }
- W4327894037 endingPage "1108" @default.
- W4327894037 startingPage "1094" @default.
- W4327894037 abstract "Transcriptional programming leverages systems of engineered transcription factors to impart decision-making (e.g., Boolean logic) in chassis cells. The number of components used to construct said decision-making systems is rapidly increasing, making an exhaustive experimental evaluation of iterations of biological circuits impractical. Accordingly, we posited that a predictive tool is needed to guide and accelerate the design of transcriptional programs. The work described here involves the development and experimental characterization of a large collection of network-capable single-INPUT logical operations─i.e., engineered BUFFER (repressor) and engineered NOT (antirepressor) logical operations. Using this single-INPUT data and developed metrology, we were able to model and predict the performances of all fundamental two-INPUT compressed logical operations (i.e., compressed AND gates and compressed NOR gates). In addition, we were able to model and predict the performance of compressed mixed phenotype logical operations (A NIMPLY B gates and complementary B NIMPLY A gates). These results demonstrate that single-INPUT data is sufficient to accurately predict both the qualitative and quantitative performance of a complex circuit. Accordingly, this work has set the stage for the predictive design of transcriptional programs of greater complexity." @default.
- W4327894037 created "2023-03-21" @default.
- W4327894037 creator A5022081410 @default.
- W4327894037 creator A5035922814 @default.
- W4327894037 creator A5047956072 @default.
- W4327894037 creator A5051928700 @default.
- W4327894037 creator A5068647452 @default.
- W4327894037 creator A5068994727 @default.
- W4327894037 creator A5078923254 @default.
- W4327894037 date "2023-03-20" @default.
- W4327894037 modified "2023-10-14" @default.
- W4327894037 title "Performance Prediction of Fundamental Transcriptional Programs" @default.
- W4327894037 cites W1499816395 @default.
- W4327894037 cites W1645305843 @default.
- W4327894037 cites W1973256834 @default.
- W4327894037 cites W1979159575 @default.
- W4327894037 cites W2007769474 @default.
- W4327894037 cites W2011083779 @default.
- W4327894037 cites W2015244769 @default.
- W4327894037 cites W2027350316 @default.
- W4327894037 cites W2036051969 @default.
- W4327894037 cites W2058131374 @default.
- W4327894037 cites W2073588416 @default.
- W4327894037 cites W2114228460 @default.
- W4327894037 cites W2123097315 @default.
- W4327894037 cites W2129660964 @default.
- W4327894037 cites W2130912501 @default.
- W4327894037 cites W2132828256 @default.
- W4327894037 cites W2134759932 @default.
- W4327894037 cites W2164048734 @default.
- W4327894037 cites W2190320496 @default.
- W4327894037 cites W2192893656 @default.
- W4327894037 cites W2330245166 @default.
- W4327894037 cites W2463822315 @default.
- W4327894037 cites W2507618556 @default.
- W4327894037 cites W2515895007 @default.
- W4327894037 cites W2569705874 @default.
- W4327894037 cites W2570895165 @default.
- W4327894037 cites W2883788138 @default.
- W4327894037 cites W2886599617 @default.
- W4327894037 cites W2900498998 @default.
- W4327894037 cites W2906891182 @default.
- W4327894037 cites W2932346662 @default.
- W4327894037 cites W2980582516 @default.
- W4327894037 cites W3013024485 @default.
- W4327894037 cites W3046581440 @default.
- W4327894037 cites W3083243111 @default.
- W4327894037 cites W3134710249 @default.
- W4327894037 cites W3137360202 @default.
- W4327894037 cites W3212423813 @default.
- W4327894037 cites W4284889840 @default.
- W4327894037 doi "https://doi.org/10.1021/acssynbio.2c00593" @default.
- W4327894037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36935615" @default.
- W4327894037 hasPublicationYear "2023" @default.
- W4327894037 type Work @default.
- W4327894037 citedByCount "1" @default.
- W4327894037 countsByYear W43278940372023 @default.
- W4327894037 crossrefType "journal-article" @default.
- W4327894037 hasAuthorship W4327894037A5022081410 @default.
- W4327894037 hasAuthorship W4327894037A5035922814 @default.
- W4327894037 hasAuthorship W4327894037A5047956072 @default.
- W4327894037 hasAuthorship W4327894037A5051928700 @default.
- W4327894037 hasAuthorship W4327894037A5068647452 @default.
- W4327894037 hasAuthorship W4327894037A5068994727 @default.
- W4327894037 hasAuthorship W4327894037A5078923254 @default.
- W4327894037 hasBestOaLocation W43278940371 @default.
- W4327894037 hasConcept C113775141 @default.
- W4327894037 hasConcept C11413529 @default.
- W4327894037 hasConcept C131017901 @default.
- W4327894037 hasConcept C191908910 @default.
- W4327894037 hasConcept C199360897 @default.
- W4327894037 hasConcept C2780801425 @default.
- W4327894037 hasConcept C41008148 @default.
- W4327894037 hasConcept C70721500 @default.
- W4327894037 hasConcept C80444323 @default.
- W4327894037 hasConcept C86803240 @default.
- W4327894037 hasConceptScore W4327894037C113775141 @default.
- W4327894037 hasConceptScore W4327894037C11413529 @default.
- W4327894037 hasConceptScore W4327894037C131017901 @default.
- W4327894037 hasConceptScore W4327894037C191908910 @default.
- W4327894037 hasConceptScore W4327894037C199360897 @default.
- W4327894037 hasConceptScore W4327894037C2780801425 @default.
- W4327894037 hasConceptScore W4327894037C41008148 @default.
- W4327894037 hasConceptScore W4327894037C70721500 @default.
- W4327894037 hasConceptScore W4327894037C80444323 @default.
- W4327894037 hasConceptScore W4327894037C86803240 @default.
- W4327894037 hasFunder F4320337390 @default.
- W4327894037 hasIssue "4" @default.
- W4327894037 hasLocation W43278940371 @default.
- W4327894037 hasLocation W43278940372 @default.
- W4327894037 hasLocation W43278940373 @default.
- W4327894037 hasOpenAccess W4327894037 @default.
- W4327894037 hasPrimaryLocation W43278940371 @default.
- W4327894037 hasRelatedWork W1969324738 @default.
- W4327894037 hasRelatedWork W2149778176 @default.
- W4327894037 hasRelatedWork W2152161767 @default.
- W4327894037 hasRelatedWork W2294460196 @default.
- W4327894037 hasRelatedWork W2351571780 @default.