Matches in SemOpenAlex for { <https://semopenalex.org/work/W4327896615> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4327896615 endingPage "1871" @default.
- W4327896615 startingPage "1861" @default.
- W4327896615 abstract "We examined the effects of the polymer-additive and drug chiralities on the ketoprofen (KTP) supersaturation region using temperature-variable nuclear magnetic resonance (NMR). Quantitative NMR analysis revealed that the racemic KTP and corresponding S-enantiomer (rac- and s-KTP) exhibited similar amorphous solubilities in a buffer, while the crystalline solubility of s-KTP was higher than that of rac-KTP. Therefore, rac-KTP exhibited a larger supersaturation region than s-KTP. In contrast, polyvinylpyrrolidone (PVP) reduced the amorphous solubility of both rac- and s-KTP, whereas the crystalline solubility of KTP remained unchanged. Partitioning PVP into the KTP-rich phase reduced the chemical potential of KTP in the KTP-rich phase and the amorphous solubility of KTP. At higher temperatures, the distribution of PVP into the KTP-rich phase became more significant, which considerably reduced the amorphous solubility. Because the upper limit of the KTP supersaturation decreased, PVP narrowed the KTP supersaturation region. The maximum KTP supersaturation ratio decreased with increasing temperature, and the supersaturated dissolvable area of KTP finally disappeared. The maximum temperature at which KTP can form the supersaturation was lowered by replacing rac- with s-KTP and the addition of PVP. The maximum supersaturation temperature was dominated by the melting behavior of crystalline KTP in an aqueous solution. The present study highlighted that a quantitative understanding of the supersaturation region is essential to determine whether supersaturated formulations are beneficial for improving the oral absorption of poorly water-soluble drugs." @default.
- W4327896615 created "2023-03-21" @default.
- W4327896615 creator A5015206704 @default.
- W4327896615 creator A5057401220 @default.
- W4327896615 creator A5090660967 @default.
- W4327896615 date "2023-03-20" @default.
- W4327896615 modified "2023-09-30" @default.
- W4327896615 title "Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 1: Effects of Polymer and Drug Chiralities" @default.
- W4327896615 cites W1721131318 @default.
- W4327896615 cites W1990406672 @default.
- W4327896615 cites W1993806082 @default.
- W4327896615 cites W1995256101 @default.
- W4327896615 cites W1999828399 @default.
- W4327896615 cites W2039316284 @default.
- W4327896615 cites W2063931580 @default.
- W4327896615 cites W2071988345 @default.
- W4327896615 cites W2077832397 @default.
- W4327896615 cites W2103059913 @default.
- W4327896615 cites W2304404543 @default.
- W4327896615 cites W2315526175 @default.
- W4327896615 cites W2320089805 @default.
- W4327896615 cites W2320607110 @default.
- W4327896615 cites W2346169493 @default.
- W4327896615 cites W2618686510 @default.
- W4327896615 cites W2753909010 @default.
- W4327896615 cites W2790926352 @default.
- W4327896615 cites W2900438200 @default.
- W4327896615 cites W2915584132 @default.
- W4327896615 cites W2982582908 @default.
- W4327896615 cites W3008405277 @default.
- W4327896615 cites W3022096649 @default.
- W4327896615 cites W3036803938 @default.
- W4327896615 cites W3111665617 @default.
- W4327896615 cites W3130899234 @default.
- W4327896615 cites W3177061949 @default.
- W4327896615 cites W3208002539 @default.
- W4327896615 cites W4289766952 @default.
- W4327896615 doi "https://doi.org/10.1021/acs.molpharmaceut.2c00924" @default.
- W4327896615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36939575" @default.
- W4327896615 hasPublicationYear "2023" @default.
- W4327896615 type Work @default.
- W4327896615 citedByCount "1" @default.
- W4327896615 countsByYear W43278966152023 @default.
- W4327896615 crossrefType "journal-article" @default.
- W4327896615 hasAuthorship W4327896615A5015206704 @default.
- W4327896615 hasAuthorship W4327896615A5057401220 @default.
- W4327896615 hasAuthorship W4327896615A5090660967 @default.
- W4327896615 hasConcept C113196181 @default.
- W4327896615 hasConcept C127413603 @default.
- W4327896615 hasConcept C155574463 @default.
- W4327896615 hasConcept C178790620 @default.
- W4327896615 hasConcept C185592680 @default.
- W4327896615 hasConcept C192562407 @default.
- W4327896615 hasConcept C200447597 @default.
- W4327896615 hasConcept C203036418 @default.
- W4327896615 hasConcept C2780077769 @default.
- W4327896615 hasConcept C42360764 @default.
- W4327896615 hasConcept C44280652 @default.
- W4327896615 hasConcept C56052488 @default.
- W4327896615 hasConcept C8010536 @default.
- W4327896615 hasConceptScore W4327896615C113196181 @default.
- W4327896615 hasConceptScore W4327896615C127413603 @default.
- W4327896615 hasConceptScore W4327896615C155574463 @default.
- W4327896615 hasConceptScore W4327896615C178790620 @default.
- W4327896615 hasConceptScore W4327896615C185592680 @default.
- W4327896615 hasConceptScore W4327896615C192562407 @default.
- W4327896615 hasConceptScore W4327896615C200447597 @default.
- W4327896615 hasConceptScore W4327896615C203036418 @default.
- W4327896615 hasConceptScore W4327896615C2780077769 @default.
- W4327896615 hasConceptScore W4327896615C42360764 @default.
- W4327896615 hasConceptScore W4327896615C44280652 @default.
- W4327896615 hasConceptScore W4327896615C56052488 @default.
- W4327896615 hasConceptScore W4327896615C8010536 @default.
- W4327896615 hasFunder F4320310760 @default.
- W4327896615 hasFunder F4320323467 @default.
- W4327896615 hasFunder F4320323513 @default.
- W4327896615 hasFunder F4320334764 @default.
- W4327896615 hasIssue "4" @default.
- W4327896615 hasLocation W43278966151 @default.
- W4327896615 hasLocation W43278966152 @default.
- W4327896615 hasOpenAccess W4327896615 @default.
- W4327896615 hasPrimaryLocation W43278966151 @default.
- W4327896615 hasRelatedWork W1976019421 @default.
- W4327896615 hasRelatedWork W2039113085 @default.
- W4327896615 hasRelatedWork W2052034920 @default.
- W4327896615 hasRelatedWork W2066372970 @default.
- W4327896615 hasRelatedWork W2089252772 @default.
- W4327896615 hasRelatedWork W2169796533 @default.
- W4327896615 hasRelatedWork W2388501402 @default.
- W4327896615 hasRelatedWork W2905035233 @default.
- W4327896615 hasRelatedWork W2905153366 @default.
- W4327896615 hasRelatedWork W4297327868 @default.
- W4327896615 hasVolume "20" @default.
- W4327896615 isParatext "false" @default.
- W4327896615 isRetracted "false" @default.
- W4327896615 workType "article" @default.