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- W4327896677 abstract "Alcohol-associated liver disease due to harmful alcohol use and non-alcoholic fatty liver disease associated with metabolic syndrome are the two most common liver diseases worldwide. Control of respective risk factors is the cornerstone in the long-term management of these diseases. Furthermore, there are no effective therapies. Both diseases are characterized by metabolic derangements, thus, the focus of this review is to broaden our understanding of metabolic targets investigated in non-alcoholic fatty liver disease, and how these can be applied to alcohol-associated liver disease. Conserved pathogenic pathways such as dysregulated lipid metabolism, cell death pathways including apoptosis, activation of innate immune cells and stellate cells mediate both alcohol and non-alcoholic fatty liver diseases, resulting in histological abnormalities of steatosis, inflammation, fibrosis, and cirrhosis. However, pathways such as gut microbiome changes, glucose metabolism and insulin resistance, inflammatory signaling, and micro-RNA abnormalities are distinct in these two diseases. In this review article, we describe conserved and distinct pathogenic pathways highlighting therapeutic targets which may be of potential in both diseases, and those which are unique to each disease." @default.
- W4327896677 created "2023-03-21" @default.
- W4327896677 creator A5002077162 @default.
- W4327896677 creator A5048615239 @default.
- W4327896677 creator A5087206886 @default.
- W4327896677 date "2023-03-21" @default.
- W4327896677 modified "2023-09-23" @default.
- W4327896677 title "Emerging targets for therapy in ALD: Lessons from NASH" @default.
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